Oklahoma City Thunder vs Detroit Pistons Prediction, Preview and Odds - 02/25/2026

Game Time: 7:30 pm ET, Wednesday, February 25, 2026

Venue:  Little Caesars Arena, Detroit, MI 

Where to Watch:  ESPN

DraftKings:  Point Spread:  Thunder +5.5, Pistons -5.5; Over/Under:  218.5 points

Bet365:  Point Spread:  Thunder +5.5, Pistons -5.5; Over/Under:  218.5 points

BetMGM:  Point Spread:  Thunder +5.5, Pistons -5.5; Over/Under:  218.5 points

Oklahoma City Thunder:  44-14 (1st place, Northwest Division)

Detroit Pistons:  42-14 (1st place, Central Division)

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Oklahoma City Thunder:  6-4 last 10

Detroit Pistons:  8-2 last 10

The Thunder are entering this game with a 44-14 record overall this season and they are 20-7 in their road games this season where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Brooklyn Nets and the Cleveland Cavaliers, but this is also the 2nd game of a back-to-back for them with their game against the Toronto Raptors still to be played on Tuesday night. In their game against the Cavaliers, Isaiah Joe led the team in points in that game with 22 while Cason Wallace was next on the team with 20 points. Cason Wallace led the team in assists in that game with 10 while Chet Holmgren led the team in rebounds with 15. They were 48.8% from the field, 51.2% from 3-point range, and 64% from the free throw line with their shots in that game. Their offense is averaging 119.5 PPG and their defense is allowing their opponents to average 107.7 PPG against them. The Thunder have an ATS record of 29-29 this season and their O/U record is 30-28.

The Pistons are entering this game with a 42-14 record overall this season and they are 21-7 in their home games this season where they will be in this game. They are entering this game off a loss against the San Antonio Spurs. Jalen Duren led the team in points in that game with 25 while Cade Cunningham was next on the team with 16 points. Cade Cunningham led the team in assists in that game with 10 while Jalen Duren led the team in rebounds with 14. They were 37.7% from the field, 19.4% from 3-point range, and 84.2% from the free throw line with their shots in that game. Their offense is averaging 117.3 PPG and their defense is allowing their opponents to average 109.4 PPG against them. The Pistons have an ATS record of 30-26 this season and their O/U record is 24-31-1.

The current betting odds have the Pistons listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. The Pistons have looked great in their games this season with their 42-14 record overall which has them right at the top of the East with one of the best records in the entire NBA. They have looked great on their home court too with their 21-7 home record this season. Meanwhile, the Thunder have looked great in their games this season with their 44-14 record overall which has them right at the top of the West with the best record in the entire NBA. They have been a great road team too with their 20-7 road record this year. The Thunder are the defending NBA Champions from last season and they have once again been the best team in the NBA this regular season. They have looked good lately too as they are 6-4 in their last 10 games, but they definitely haven't been at their best lately. They have won 2 games in a row now, but they are also banged up with some key starters out for this game, and they aren't in a great situation here either. They are already missing their best player SGA along with some other key players, and they are also playing this game on a back-to-back after a road game against a good Raptors team. They aren't going to have their best effort here on the road on a back-to-back, and the Pistons will be looking to bounce back in a big way. The Pistons are off a bad home loss to the Spurs in their last one, but they have been the best team in the East all year and they have been rolling lately too, going 8-2 in their last 10 games. Look for the Pistons to bounce back on their home court and take advantage of a banged up Thunder team on the road on a back-to-back here. The best way to place a bet here is on the Pistons to cover the spread in this game. 

Thunder Pistons Prediction:  Our NBA Pick for Wednesday, February 25, 2026 (7:30 pm ET start time) is Pistons 113 Thunder 105.

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Oklahoma City Thunder: 22-12 ATS against Central division opponents. 16-10 ATS as an underdog. 51-33 ATS in non-conference games. 11-6 UNDER as a road underdog of 6 points or less. 

Detroit Pistons: 11-24 ATS as a home favorite of 6 points or less. 14-25 ATS at home in non-conference games. 23-12 UNDER as a home favorite of 6 points or less. 11-4 UNDER versus good teams - outscoring their opponents by 3+ points/game.

Oklahoma City Thunder:  C. Holmgren (C) Day To Day - Back. A. Caruso (SG) Day To Day - Ankle. J. Williams (SG) Out - Hamstring. S. Gilgeous-Alexander (PG) Out - Abdomen. A. Mitchell (SG) Out - Abdomen. T. Sorber (C) Out For Season - Knee.

Detroit Pistons:  None.

"The injuries are a challenge, but there's a vast number of challenges that you face in the 82-game season." - Mark Daigneault on his team’s injuries at the moment.

"I thought Ron played well tonight." - J.B. Bickerstaff on Ron Holland after his team’s loss against the Spurs in their game on Monday.

PG Nikola Topic

SG Luguentz Dort

SF Alex Caruso 

PF Chet Holmgren

C Isaiah Hartenstein

PG Cade Cunningham

SG Duncan Robinson

SF Ausar Thompson

PF Tobias Harris

C Jalen Duren

PPG: Shai Gilgeous-Alexander (31.8)

APG: Shai Gilgeous-Alexander (6.4)

Reb/G: Isaiah Hartenstein (9.5)

PPG: Cade Cunningham (25.3)

APG: Cade Cunningham (9.8)

Reb/G: Jalen Duren (10.5)

Coaches:

Oklahoma City Thunder: Mark Daigneault (6th season)

Detroit Pistons: J.B. Bickerstaff (2nd season)