by Rod Pearson
Monday, Nov 03, 2025
Game Time: 1:00 pm ET, Saturday, November 8, 2025
Venue: Ross–Ade Stadium, West Lafayette, IN
Where to Watch: Big Ten Network
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Ohio State -28.5, Purdue +28.5; Over/Under: 48.5 points
Bet365: Point Spread: Ohio State -29, Purdue +29; Over/Under: 48.5 points
BetMGM: Point Spread: Ohio State -28.5, Purdue +28.5; Over/Under: 48.5 points
Season Record
Ohio State Buckeyes: 8-0 (5-0) (2nd place, Big Ten)
Purdue Boilermakers: 2-7 (0-6) (18th place, Big Ten)
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Recent Form
Ohio State Buckeyes: won their last game at home against the Penn State Nittany Lions 38-14.
Purdue Boilermakers: lost their last game on the road against the Michigan Wolverines 21-16.
Ohio State Buckeyes vs Purdue Boilermakers Preview and Analysis
Ohio State is entering this game with an 8-0 record overall and they have a 5-0 record in their conference games too. They are 5-0 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Penn State 38-14. Julian Sayin was the starting QB and he completed 20/23 passes for 316 passing yards, 4 touchdowns, and 0 interceptions. Bo Jackson led the team in rushing yards with 105. Carnell Tate led the receivers with 124 receiving yards on 5 receptions and 1 TD. Arvell Reese led the defense in that game with 5 solo tackles and 8 assisted tackles while Kenyatta Jackson Jr. led the defense in sacks with 2. Caleb Downs came away with the only interception for them in that one.
Purdue is entering this game with a 2-7 record overall and they have a 0-6 record in their conference games too. They are 2-3 in their home games, 0-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Michigan 21-16. Ryan Browne was the starting QB and he completed 19/24 passes for 133 passing yards, 1 touchdown, and 0 interceptions. Malachi Thomas led the team in rushing yards with 68. Michael Jackson III led the receivers with 58 receiving yards on 6 receptions. Tahj Ra-El led the defense in that game with 10 solo tackles and 2 assisted tackles while Mani Powell led the defense in sacks with 1.5. Hudauri Hines came away with the only interception for them in that one.
Ohio State vs Purdue Prediction
The current betting odds have Ohio State listed as a 28.5 point favorite in this game according to Draftkings Sportsbook. Ohio State has looked great in their games this season with their 8-0 record overall and their 5-0 conference record which has them right near the top of the Big Ten. They have been a good road team too with their 3-0 road record this season and they are currently ranked number 1 overall. They are off a 38-14 win over Penn State in their last one and that has been a common theme for them this season. Meanwhile, Purdue has looked terrible in their games this season with their 2-7 record overall and their 0-6 conference record which has them right at the bottom of the Big Ten. They haven't looked great on their home field either with their 2-3 home record this year. They didn't look bad in their last one as they went on the road and lost in a tight one to Michigan, losing 21-16, but their offense has been a big issue all season. They haven't been putting up a ton of points in their games lately or all season, and their defense hasn't been keeping them in games either. Ohio State is the best team in the nation at the moment and even though they aren't winning games with flash, they are doing something much worse. They have the best defense in the nation that hasn't been giving up many points all year and they have been breaking the will of the offenses they have faced with that great defense. Purdue isn't going to get much done on offense here and their defense isn't going to be able to keep Ohio State off the board either. The best way to place a bet here is on Ohio State to cover the spread in this game.
Ohio State Purdue Prediction: Our NCAAF Pick for Saturday, November 8, 2025 (1:00 pm ET start time) is Ohio State 42 Purdue 3.
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NCAAF Betting Trends
Ohio State Buckeyes: 24-11 ATS in all lined games. 17-7 ATS against conference opponents. 17-6 ATS after allowing 14 points or less last game. 23-14 UNDER in all lined games. 9-2 UNDER as a road favorite. 14-6 UNDER off a win against a conference rival.
Purdue Boilermakers: 10-22 ATS in all lined games. 3-8 ATS as a home underdog. 7-16 ATS against conference opponents. 3-7 ATS off a road loss against a conference rival. 5-0 UNDER after a loss by 6 or less points. 8-2 UNDER versus good defensive teams - allowing 310 yards/game or less.
Key Injuries
Ohio State Buckeyes: Q. Porter (WR) Questionable - Undisclosed. M. Hartford (S) Questionable - Undisclosed. M. Maggs (QB) Questionable - Undisclosed. M. Roy (DL) Questionable - Undisclosed. A. Tounkara (DL) Questionable - Undisclosed. T. Rogers (RB) Questionable - Undisclosed. L. George (DL) Questionable - Undisclosed.
Purdue Boilermakers: D. Mockobee (RB) Questionable - Undisclosed. A. Coffey (CB) Questionable - Undisclosed. C. Magwood (WR) Questionable - Undisclosed. G. Burhenn (TE) Questionable - Undisclosed. D. Morrissette (WR) Questionable - Undisclosed. J. Hall (WR) Out - Leg.
Notable Quotes
“We came in at halftime and we were up by three — you would have thought we were down by 21, but I thought we responded well. I thought some of Julian's deep balls were excellent. We saw how they were playing us in the first half, felt we had a chance to get behind them and called those plays.” - Ryan Day after his team’s win against PSU in their last game.
“I was here to win the game. I thought we needed to find a way to get points out of that possession. We didn’t. We came up a couple inches short. Absolutely no regret on the play call.” - Barry Odom after his team’s loss against Michigan in their last game.
Starting Lineups
Ohio State Buckeyes
WR Tate, Carnell
WR Smith, Jeremiah
WR Inniss, Brandon
TE Klare, Max
QB Sayin, Julian
RB Jackson, Bo
Purdue Boilermakers
WR Tuggle, Nitro
WR Horton Jr., EJ
WR Jackson III, Michael
TE Burhenn, George
QB Browne, Ryan
RB Mockobee, Devin
Statistical Leaders
Ohio State Buckeyes
Passing: Julian Sayin (2,188)
Rushing: Bo Jackson (538)
Receiving: Jeremiah Smith (725)
Touchdowns: Jeremiah Smith (10)
Purdue Boilermakers
Passing: Ryan Browne (1,822)
Rushing: Devin Mockobee (521)
Receiving: Michael Jackson III (456)
Touchdowns: Devin Mockobee (5)
Coaches:
Ohio State Buckeyes: Ryan Day (8th season)
Purdue Boilermakers: Barry Odom (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
