NFL: Los Angeles Chargers VS Arizona Cardinals Prediction and Picks 11/27/2022

by James Q

NFL: Los Angeles Chargers VS Arizona Cardinals Prediction and Picks 11/27/2022 

Game Time:  4:00 PM ET, Sunday, November 27th, 2022
Venue: State Farm Stadium, Glendale, Arizona
Where to Watch:  CBS, Paramount +

Odds at USA Sportsbooks

FanDuel: point spread: Chargers -4; O/U 47.5
BetMGM:  Chargers -4.5; O/U 47.5
Caesars:  Chargers -4.5; O/U 47.5

Season Record

Chargers: 5-5, 2nd place AFC West
Cardinals: 4-7 NFC West

An inter conference matchup between NFL teams with wildly different squads… yet eerily similar records.  They are only separated by 1 win,  it feels like the visiting team is on the way to irrelevance while the home team is falling apart.  The Los Angeles Chargers have lost 3 of their last 4 games completely tanking their season.  QB Justin Herbert is caught up in some wild curse of the Chargers… year after year the Chargers have a good quarterback (some for full decades) and a fine roster… and either bungle close games or get bit by the injury bug.  Everyone thinks that Justin Herbert is top notch… big kid, big arm, lots of talent that comes with lots of expectations… not nearly enough wins.  The Chargers have big expectations but they are also a team that lost to the Jacksonville Jaguars 38-10 back in September!  They have however been a very safe bet ATS… in fact they are 7-3 ATS.  The Arizona Cardinals signed a bad BIG contract with their very SMALL quarterback.  It is that simple.  There are hurt feelings all around and what the universe has been saying is coming true: “Kyler Murray is too small to make it through a season without missing games to injury”.  The result of last offseason’s contract muckety muck is hurt feelings for everyone. Teams survive a lot of things.. Not hurt feelings. The Cardinals have won not enough games to contend in their own division… and will probably start trying too hard in every game.

The Los Angeles Chargers lost their last game to the Kansas City Chiefs 30-27.  That is THE most important AFC rival for the Chargers… and year after year they get stumped. The game looked like it could go the Chargers way several times throughout play QB Justin Herbert was 23 of 30 for 280 yards with 2 TDs and 1 INT.  RB Austin Ekeler went for 83 yards on 19 carries with 1 TD.  WR Joshua Palmer had 8 receptions for 106 yards and he caught those 2 TDs.  But hey could not hold off the Chiefs QB Patrick Mahomes who tore them up for 20 of 34 with 329 yards and 3 TDs.  The final score was close… The Chargers got the win ATS… but ultimately the Chargers are still the team that can not win the big games.  It would have helped if WR Mike Williams could have played.  In the Chiefs game Mike was returning from injury and immediately went back out with injury. Defensive star LB Joey Bosa is still out with a groin injury.. In fcat lots of Chargers keep missing lots of games.

The Arizona Cardinals have lost 3 of their last 4 games.  They lost their last game in Mexico City to the San Francisco 49ers 38-10.  It was not as close as that absurd score.  You could blame it on the high altitude or that the Cardinals were again missing QB Kyler Murray?  But the truth is the Cardinals keep losing and may be terrible. It is currently uncertain if Kyler will play against the Chargers… if he does not?... Bet the house on the Chargers… If he does… only consider betting the House against the Chargers.

Sean Murphy is 21-11 in the last 30 days of the NFL for a profit of $8,950 with  BIG Winners everywhere! Get Sean Murphy’s picks!!....  Follow a handicapper soon!  They are available right now at the Shop Picks Page, where you can find all of the Best Bets from our champion sports handicappers.  And stay with for all your favorite sports… MLB, NBA, NFL, NHL, NCAAF, NCAAB.  Remember winning a wager is more fun than making the wager… more profitable too!!

Los Angeles Chargers VS Arizona Cardinals Preview and Analysis

LAC: 5-5, 7-3 ATS, 5-5 O/U, 3-2 in road games.
ARI: 4-7, 5-6 ATS, 6-5 O/U, 1-4 in home games.

Offensive Analysis

The Los Angeles Chargers are 14th in scoring with 22.7 points per game, 17th in total yards per game with 351.7 per game, 6th in passing yards with 263.8 per game, and 30th in rushing yards with 87.9 per game.

The Arizona Cardinals are 18th in scoring with 21.8 points per game, 10th in total yards with 331.9 per game, 16th in passing yards with 223 per game, 21st in rushing yards with 108.9 per game.

Defensive Analysis

The Chargers defense is 25th in defense of 369 per game allowed, 19th in defense of passing yards with 220.6 per game allowed, 30th in rushing yards with 148.4 allowed per game, and 29th in points allowed with 25.8 per game.

The Cardinals defense is 24th in total yards allowed with 360.3 per game, 23rd in passing yards allowed with 245.4 per game, 13th in rushing yards allowed with 114.9 per game, 31st in points allowed with 26.9 per game.

Los Angeles Chargers VS Arizona Cardinals Prediction

Our prediction for Sunday, November 27th is… Chargers 27 - Cardinals 19
Both of these defenses are broken… They both suffer from the injury bug.  The Chargers offense is slightly better.  The Chargers chances at a postseason spot are slightly greater.  Bet on the Chargers whether Kyler plays or not.  A 4.5 spread should not deter you.
Don't miss our champion handicappers' Free NFL Picks and Premium Selections every day here at  Just click on Shop Picks for our Best Bets, or click on Shop Subscriptions to join for a week or a month.  And if you enjoyed this Chargers/Cardinals preview, be sure to bookmark for our daily Game Previews and Predictions.

NFL Betting Trends

The Chargers are 3-0 ATS as a road favorite this season.
The Chargers are 54-32 ATS in road games where the total is greater than 45.5 since 1992.
The Cardinals are 5-14 ATS in home games where the total is 45.5 or greater the last 3 seasons.

Starting Lineups

Chargers: QB Justin Herbert, RB Austin Ekeler, FB Zander Horvath, WR Keenan Allen, WR Mike Williams, TE Richard Rodgers, LT Jaree Salyer, LG Matt Feiler, C Corey Linsley, RG Zion Johnson, RT Trey Pipkins III

Cardinals: QB Colt McCoy OR Kyler Murray, RB James Conner, WR Rondale Moore, WR Deandre Hopkins, WR AJ Green, TE Trey McBride, LT Josh Jones, LG Rashaad Coward, C Billy Price, RG Lecitus Smith, RT Kelvin Beachum


Mostly Sunny, 70*, Humidity 19%, wind 4 mph… welcome to Phoenix… have some winter sunscreen.

James Q

About the Author:

James Q. has been involved with sports and gambling his entire life. A former division 1 scholarship basketball player, James understands sports (and especially basketball) inside-and-out. Following his basketball playing days, James parlayed his gambling skills into a semi-pro poker career. James resides in Los Angeles, and especially loves the Los Angeles Clippers, Los Angeles Rams, and Los Angeles Dodgers. And when he isn't betting on sports (and writing about it), James can be found performing stand-up comedy on the Sunset Strip.

All photographic images used for editorial content have been licensed from the Associated Press.

© 2022 Al McMordie's All Rights Reserved.