NFL Football: Kansas City Chiefs vs Arizona Cardinals Prediction, Odds and Preview - 09/11/2022

by James Q

Wednesday, Sep 07, 2022

NFL Football:  Kansas City Chiefs vs Arizona Cardinals Prediction, Odds and Preview - 09/11/2022

Game Time: 4:25 PM EDT,  Sunday, September 11th, 2022
Venue:  Bank of America Stadium, Charlotte, North Carolina
Where to Watch: CBS, Paramount +

Opening MLB Odds at USA Sportsbooks

FanDuel:  Chiefs -5.5; O/U 53.5
BetMGM: Chiefs -6; O/U 53.5

Season Record

Chiefs: 12-5, 1st place AFC West
Cardinals: 11-6, 2nd place NFC West

Hot young quarterbacks making BIG money square off in this inter-conference matchup.  The Kansas City Chiefs won the AFC West last season behind the play of Patrick Mahomes and his high flying fast charging weapons.  The fastest among the weapons, WR Tyreek Hill, left for a greener uniform in Miami.  This led to a scramble to restock the shelves that found the Chiefs bringing in WR Juju Smith-Schuster and WR Marquez Valdes-Scantling.  The Chiefs will have a whole new look… will they be as good?... Will they be better?.  The worry is that maybe Mahomes has regressed a bit.  He was beaten in the Playoffs last year by Joe Burrow and the Cincinnati Bengals.  The Arizona Cardinals is led by star, miniature QB Kyler Murray.  This kid is fast, this kid is tough, this kid has a tendency to wear down by the end of the season.  Last season Kyler and the Cards had an early win over the Los Angeles Rams… when they met again much later the Rams beat the Cards easily and kept on trucking all the way to a Super Bowl Championship.  This offseason was rough for Kyler and the Cards… It was an eerily similar feeling to Kyler’s draft a few years back… When Kyler was drafted the Cardinals were given an ultimatum to draft him early or Kyler would walk to play baseball.  It worked, the Cardinals scooped Kyler with the #1 pick!... This last offseason the Cards were again given an ultimatum… Kyler wanted a BIG new Contract or he might hold out… He might not show up for Camp… he might not be happy.  The Kyler criticism from his 2019 draft was brought up again 1) the guy is small, 2) He doesn’t do his homework, 3) He is simply not a solid leader 4) He will get hurt…. After weighing all their options… The Cardinals decided Kyler would get the money in a BIG New Contract.  They also decided to add an insulting clause in the Contract that Kyler do actual film study.  Kyler signed for BIG money… and then his agent made the clause public which embarrassed the Cardinals and it was dropped.  Long story short:  Kyler is talented enough to simply keep him and keep trying.

Patrick Mahomes was drafted in 2017 and has since made 4 Pro-Bowls, won a Super Bowl, won Super Bowl MVP, and has built a career passer rating of 105.8.

Kyler Murray was drafted in 2019 and has made 2 Pro-Bowls, was NFL Offensive Rookie of the Year, and has built a career passer rating of 93.9… His superpower is the rushing aspect of his game which has amassed 1,786 yards for 20 touchdowns.
Oskeim Sports was 32-20 last season in NFL picks for a profit of +$9,400!! Go Get 'em!! Get Oskeim Sports picks!!… You could also look at  Matt Fargo who was 53-41 last season of NFL picks for a profit of $8,370!!…. Follow a handicapper soon!  They are available right now at the Shop Picks Page, where you can find all of the Best Bets from our champion sports handicappers.  And stay with for all your favorite sports… MLB, NBA, NFL, NHL, NCAAF, NCAAB.  Remember winning a wager is more fun than making the wager… more profitable too!!


Kansas City Chiefs vs Arizona Cardinals Preview and Analysis


Chiefs vs Cardinals Prediction

Our prediction for Sunday September 11th is…. Chiefs 31 - Cardinals 21
The Cardinals are 6-0 ATS as an underdog of 3.5 to 9.5 points. That streak will be broken.  They are going up against the Chiefs who did lose Tyreek Hill (their best receiver), but the Cards also lost their best receiver in Deandre Hopkins suspension.  The difference is that the Chiefs got players and picks in return for Hill… while the Cards of course got nothing for Hopkins absence.  Plus you already know that the best story for the Sports Media will be for Kyler Murray to start the season with a loss after much ado was made about his contract negotiations.  You can already see the tweets (Did Kyler Watch Any Film?).
The bet is for the Chiefs to cover the spread.  You may be tempted to take the OVER… but hold off betting the Over for either of these teams until you see how they operate with the missing receivers.  
Don't miss our champion handicappers' Free NFL Picks and Premium Selections every day here at  Just click on Shop Picks for our Best Bets, or click on Shop Subscriptions to join for a week or a month.  And if you enjoyed this Chiefs/Cardinals preview, be sure to bookmark for our daily Game Previews and Predictions.

NFL Betting Trends

Kansas City is 22-10 ATS against NFC West division opponents since 1992.
Arizona is 6-0 ATS as an underdog of 3.5 to 9.5 points the last 3 seasons.

Key Injuries

Chiefs: OL L Niang OUT ** TE B Bell Out ** 

Cardinals: WR Antoine Wesley Out ** WR Deandre Hopkins (suspended) OUT


Starting Lineups

Chiefs:  QB Patrick Mahomes, RB Clyde Edwards-Helaire, WR Ju Ju Smith-Schuster, WR Marquez Valdes-Scantling, WR Mercole Hardman, TE Travis Kelce, FB Michael Burton, LT Orlando Brown Jr, LG Joe Thuney, C Creed Humphrey, RG Trey Smith, RT Andrew Wylie

Cardinals: QB Kyler Murray, RB James Connor, WR Marquise Brown, WR AJ Green, WR Rondale Green, TE Zach Ertz, LT DJ Humphries, LG Justin Pugh, C Rodney Hudson, RG Will Hernandez, RT Kelvin Beachum


James Q

About the Author:

James Q. has been involved with sports and gambling his entire life. A former division 1 scholarship basketball player, James understands sports (and especially basketball) inside-and-out. Following his basketball playing days, James parlayed his gambling skills into a semi-pro poker career. James resides in Los Angeles, and especially loves the Los Angeles Clippers, Los Angeles Rams, and Los Angeles Dodgers. And when he isn't betting on sports (and writing about it), James can be found performing stand-up comedy on the Sunset Strip.

All photographic images used for editorial content have been licensed from the Associated Press.

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