New York Yankees vs Cincinnati Reds Prediction, Preview and Odds - 06/25/2025

Game Time: 7:10 pm ET, Wednesday, June 25, 2025

Venue:  Great American Ball Park, Cincinnati, OH

Where to Watch:  MLBN, Prime Video

DraftKings:  Moneyline odds:  Yankees -208, Reds +168; Over/Under:  9 runs

Bet365:  Moneyline odds:  Yankees -210, Reds +170; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Yankees -210, Reds +170; Over/Under:  9 runs

New York Yankees:  45-33 (1st place, AL East)

Cincinnati Reds:  41-38 (4th place, NL Central)

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New York Yankees:  3-7 last 10

Cincinnati Reds:  6-4 last 10

The Yankees are entering this series off a win and won their 3-game series against the Baltimore Orioles 2-1 in their last series. They enter this game with a 45-33 record overall and have a road record of 21-17. This is the series finale of a 3-game series with the Reds on Wednesday with the 2nd game still to be played on Tuesday. The Yankees lost the series opener on Monday. Their offense ranks 2nd in the MLB with a .787 OPS. Carlos Rodón is their starting pitcher on Tuesday while Max Fried is making his start in this game on Wednesday. He is 9-2 with a 2.05 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 ER, 0 HR, and 0 BB with 7 SO on 7 hits through 6 IP against the Baltimore Orioles.

The Reds are entering this series off a win and lost their 3-game series against the St Louis Cardinals 2-1 in their last series. They enter this game with a 41-38 record overall and have a home record of 21-17. This is the 3rd game of a 3-game series with the Yankees on Wednesday with the 2nd game of this series still to be played on Tuesday. The Reds won the 1st game of this series on Monday. Their offense ranks 12th in the MLB with a .725 OPS. Rookie pitcher Chase Burns is their starting pitcher on Tuesday while Brady Singer is making his start in this game on Wednesday. He is 7-5 with a 4.13 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 1 walk with 7 strikeouts on 4 hits through 6 innings pitched against the St Louis Cardinals.

The current betting odds have the Yankees listed as a big favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 45-33 record overall which has them right at the top of the AL East. They have also been a good road team this year with their 21-17 road record. Meanwhile, the Reds have looked good in their games this season with their 41-38 record overall, but that record has them right near the bottom of the NL Central in a competitive division. They have looked better in their own ballpark with their 21-17 home record this season. The Reds won the series opener on Monday and they have looked like the better team lately as they are 6-4 in their last 10 games while the Yankees are 3-7, but the Yankees have their ace on the mound here so this is a game where they have a big pitching advantage and they will be looking to turn things around. Fried is on the mound for them and he has been great all season. He is 9-2 with a 2.05 ERA and hasn't been giving up many runs in any of his starts. He did give up 3 earned runs in his last start and the team has now lost 2 games in a row with him starting, but that hasn't been a common theme for him at all this year so he and the team will be looking to bounce back in this one. Singer is on the mound for the Reds and he hasn't looked bad lately, but he has been really up and down this season too. He is 7-5 with a 4.13 ERA and he is coming off a good start in which he gave up just 1 earned run, but that hasn't been a common theme for him and he isn't going to pitch as well against one of the best offenses in the MLB here. This is a good situation for the Yankees to bounce back in since they need a win to start turning things around. The best way to place a bet here is on the Yankees to win this game and on the run line. 

Yankees Reds Prediction:  Our MLB Pick for Wednesday, June 25, 2025 (7:10 pm ET start time) is Yankees 3 Reds 0.

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New York Yankees: 19-18 (-8 units) on the moneyline against NL Central opponents. 228-186 (-19 units) on the moneyline in all games. 171-128 (-29.1 units) on the moneyline as a favorite of -110 or higher. 29-22 UNDER on the road when the total is 9 to 9.5.

Cincinnati Reds: 198-203 (+9.5 units) on the moneyline in all games. 111-128 (+20.2 units) on the moneyline as an underdog of +100 or higher. 66-56 (+16.7 units) on the moneyline in an inter-league game. 18-8 UNDER vs. an AL starting pitcher whose ERA is 3.70 or better.

New York Yankees:  R. Yarbrough (SP) Fifteen Day IL - Oblique. Y. De Los Santos (RP) Fifteen Day IL - Elbow. O. Cabrera (3B) Sixty Day IL - Ankle. J. Cousins (RP) Sixty Day IL - Elbow. M. Stroman (SP) Fifteen Day IL - Knee. L. Gil (SP) Sixty Day IL - Back. G. Cole (SP) Sixty Day IL - Elbow.

Cincinnati Reds:  W. Miley (SP) Fifteen Day IL - Flexor. G. Ashcraft (RP) Fifteen Day IL - Groin. H. Greene (SP) Fifteen Day IL - Groin. R. Lowder (SP) Sixty Day IL - Forearm. A. Hays (LF) Ten Day IL - Foot. C. Spiers (RP) Sixty Day IL - Shoulder. T. Callihan (LF) Sixty Day IL - Forearm. N. Marte (3B) Ten Day IL - Side. B. Williamson (SP) Sixty Day IL - Elbow. J. Aguiar (SP) Sixty Day IL - Elbow.

“We didn’t put the ball in play with runners out there when we had opportunities.” - Aaron Boone after his team’s loss against the Reds in their game on Monday.

“I actually love it. I love it. When he’s dirty, we’re good. He can puke on the field all he wants.” - Terry Francona on Elly De La Cruz after his team’s win against the Yankees in their game on Monday.

Paul Goldschmidt (R) 1B

Cody Bellinger (L) CF

Aaron Judge (R) RF

Giancarlo Stanton (R) DH

Jazz Chisholm Jr. (L) 3B

Anthony Volpe (R) SS

Austin Wells (L) C

DJ LeMahieu (R) 2B

Jasson Domínguez (S) LF

TJ Friedl (L) CF

Matt McLain (R) 2B

Elly De La Cruz (S) SS

Spencer Steer (R) 1B

Gavin Lux (L) LF

Tyler Stephenson (R) DH

Jose Trevino (R) C

Jake Fraley (L) RF

Christian Encarnacion-Strand (R) 3B

Batting Average:  Aaron Judge (.367)

Hits:  Aaron Judge (106)

Home Runs:  Aaron Judge (28)

RBI:  Aaron Judge (62)

Stolen Bases:  Jasson Domínguez (10)

Wins:  Carlos Rodón (9)

Saves:  Devin Williams (10)

ERA:  Adam Ottavino (0.00)

Batting Average:  Austin Wynns (.400)

Hits:  TJ Friedl (84)

Home Runs:  Elly De La Cruz (18)

RBI:  Elly De La Cruz (55)

Stolen Bases:  Elly De La Cruz (21)

Wins:  Brady Singer (7)

Saves:  Emilio Pagán (18)

ERA:  Connor Phillips (0.00)

Managers:

New York Yankees: Aaron Boone (8th season)

Cincinnati Reds: Terry Francona (1st season)