New York Yankees vs Chicago White Sox Prediction, Preview and Odds - 07/28/2026

Game Time: 7:40 pm ET, Tuesday, July 28, 2026

Venue:  Rate Field, Chicago, IL 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Yankees -144, White Sox +119; Over/Under:  8 runs

Bet365:  Moneyline odds:  Yankees -145, White Sox +120; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Yankees -145, White Sox +120; Over/Under:  8 runs

New York Yankees:  59-46 (2nd place, AL East)

Chicago White Sox:  55-49 (1st place, AL Central)

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New York Yankees:  6-4 last 10

Chicago White Sox:  6-4 last 10

The Yankees are entering this series off a loss and won their 3-game series against the Philadelphia Phillies 2-1 in their last series. They enter this game with a 59-46 record overall and have a road record of 33-23. This is the 2nd game of a 4-game series with the White Sox on Tuesday with the series opener still to be played on Monday. Their offense ranks 9th in the MLB with a .731 OPS. Max Fried is their starting pitcher on Monday while Gerrit Cole is making his start in this game on Tuesday. He is 3-5 with a 3.92 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 2 HR, and 0 BB with 11 SO on 4 hits through 7 IP against the Pittsburgh Pirates.

The White Sox are entering this series off a win and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 55-49 record overall and have a home record of 32-19. This is the 2nd game of a 4-game series with the Yankees on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 11th in the MLB with a .728 OPS. Rookie pitcher Noah Schultz is their starting pitcher on Monday while Anthony Kay is making his start in this game on Tuesday. He is 7-4 with a 4.21 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 2 walks with 4 strikeouts on 5 hits through 5 innings pitched against the Texas Rangers.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked good in their games this season with their 59-46 record overall which has them right near the top of the AL East. They have been a good road team too with their 33-23 road record this year. Meanwhile, the White Sox have looked good in their games this season with their 55-49 record overall which has them right at the top of the AL Central. They have looked great in their own ballpark too with their 32-19 home record this season. Both of these teams have had great offenses this season and both teams are 6-4 in their last 10 games respectively, but the Yankees do have the better pitching matchup here and that is going to give them the edge in this one. The Yankees are going with Cole in this one and he hasn't looked bad this season. He is 3-5 with a 3.92 ERA and he hasn't been at his best lately, but he is still a very reliable starter. He did give up 3 earned runs in his last start and the team has lost 3 games in a row now with him starting, but that is due for a change as the team will be looking to get him a win. The White Sox are going with Kay in this one and he hasn't looked great this season. He is 7-4 with a 4.21 ERA and he has been giving up quite a few runs this year. He is coming off a good start in which he gave up 2 earned runs and the team has won 2 games in a row now with him starting too, but that hasn't been a common theme for him all year and the White Sox haven't had a good bullpen this season either. Their bullpen has been blowing a lot of games for them too and the Yankees are going to have a big edge late in this game because of it. Look for the Yankees to take advantage of this pitching matchup and get Cole back in the win column here. The best way to place a bet here is on the Yankees to win this game. 

Yankees White Sox Prediction:  Our MLB Pick for Tuesday, July 28, 2026 (7:40 pm ET start time) is Yankees 5 White Sox 3.

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New York Yankees: 67-28 (+25.8 units) on the moneyline against AL Central opponents. 130-96 (+9.8 units) on the moneyline in road games. 151-93 (+12.3 units) on the moneyline vs. an AL team with a slugging percentage of .410 or worse on the season. 26-12 UNDER as a road favorite of -110 or higher.

Chicago White Sox: 29-56 (-8.4 units) on the moneyline against AL East opponents. 156-272 (-55.8 units) on the moneyline in all games. 88-125 (-13.6 units) on the moneyline in home games. 25-18 UNDER at home when playing against a good team (Win Pct. 54% to 62%).

New York Yankees:  C. Bellinger (LF) Day To Day - Leg. A. Judge (RF) Sixty Day IL - Rib. C. Rodon (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

Chicago White Sox:  K. Teel (C) Ten Day IL - Ankle. E. Pereira (RF) Seven Day IL - Concussion. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

“Some mistakes have hurt [Warren]. He got a little unlucky with the bases loaded where Bohm put a good at-bat on him and kind of dumped it out there. It’s just that next layer of execution that he needs to get to.” - Aaron Boone after his team’s loss against the Phillies in their game on Sunday. 

“It was going to come sooner or later. It’s not like I’ve been having bad approaches. I wasn’t hitting home runs, but the approach itself was good. It was all about being patient in the box.” - Munetaka Murakami after their win against the Astros in their game on Sunday. 

Paul Goldschmidt (R) 1B

Ben Rice (L) DH

Amed Rosario (R) 3B

Jasson Domínguez (S) RF

Anthony Volpe (R) SS

Trent Grisham (L) CF

Max Schuemann (R) LF

José Caballero (R) 2B

Ali Sánchez (R) C

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Braden Montgomery (S) RF

Andrew Benintendi (L) DH

Tristan Peters (L) CF

Chase Meidroth (R) 2B

Luisangel Acuña (R) SS

Drew Romo (S) C

Batting Average:  Ben Rice (.273)

Hits:  Ben Rice (102)

Home Runs:  Ben Rice (31)

RBI:  Ben Rice (72)

Stolen Bases:  Jazz Chisholm (27)

Wins:  Cam Schlittler (10)

Saves:  David Bednar (20)

ERA:  Yovanny Cruz (0.00)

Batting Average:  Sam Antonacci (.283)

Hits:  Chase Meidroth (103)

Home Runs:  Colson Montgomery (24)

RBI:  Miguel Vargas (63)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Managers:

New York Yankees: Aaron Boone (9th season)

Chicago White Sox: Will Venable (2nd season)