New York Jets vs Buffalo Bills Prediction, Preview and Odds - 01/04/2026

by Rod Pearson

Wednesday, Dec 31, 2025
Game Time: 4:25 pm ET, Sunday, January 4, 2026
Venue:  Highmark Stadium, Orchard Park, NY
Where to Watch:  CBS


Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Jets +7, Bills -7; Over/Under:  38.5 points
Bet365:  Point Spread:  Jets +7, Bills -7; Over/Under:  38 points
BetMGM:  Point Spread:  Jets +7, Bills -7; Over/Under:  38 points

Season Record

New York Jets:  3-13 (4th place, AFC East)
Buffalo Bills:  11-5 (2nd place, AFC East)

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Recent Form
New York Jets:  lost their last game at home against the New England Patriots 42-10.
Buffalo Bills:  lost their last game at home against the Philadelphia Eagles 13-12.


New York Jets vs Buffalo Bills Preview and Analysis


The Jets are entering this game with a 3-13 record overall and they have a 0-5 record in their divisional games too. They are 2-6 in their home games, 1-6 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the New England Patriots 42-10. Brady Cook was the starting QB and he completed 19/33 passes for 152 passing yards, 0 touchdowns, and 1 interception. Breece Hall led the team in rushing yards with 111 and 1 TD. John Metchie III led the receivers with 41 receiving yards on 3 receptions. Qwan'tez Stiggers led the defense in that game with 6 solo tackles and 4 assisted tackles while Khalen Saunders led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
 
 
 
The Bills are entering this game with an 11-5 record overall and they have a 3-2 record in their divisional games too. They are 6-2 in their home games, 5-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Philadelphia Eagles 13-12. Josh Allen was the starting QB and he completed 23/35 passes for 262 passing yards, 0 touchdowns, and 0 interceptions. James Cook led the team in rushing yards with 74. Brandin Cooks led the receivers with 101 receiving yards on 4 receptions. Matt Milano led the defense in that game with 4 solo tackles and 3 assisted tackles while Matt Milano and Greg Rousseau each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.


Jets vs Bills Prediction

The current betting odds have the Bills listed as a 7 point favorite in this game according to Draftkings Sportsbook. The Bills have looked good in their games this season with their 11-5 record overall which has them right near the top of the AFC East. They have looked really good on their home field too with their 6-2 home record this season. Meanwhile, the Jets have looked terrible in their games this season with their 3-13 record overall which has them right at the bottom of the AFC East with one of the worst records in the entire NFL. They have been a terrible road team too with their 1-6 road record this year. The Jets are off a 42-10 loss to the Patriots in their last one and they have looked terrible in their games lately. They have been a disaster all season and have been getting blown out in a lot of their games. They have a terrible defense that has been giving up a ton of points lately, and they have one of the worst offenses in the NFL too, now led by Brady Cook. They have also been dealing with a ton of injuries and they have nothing to play for in this game. The Bills don't have anything big to play for here since their loss to the Eagles last week eliminated them from winning their division, but they are still playing for seeding. The Bills have also been rolling in their games lately, but they are off a 13-12 loss to the Eagles in their last one, so they will be looking to bounce back with a win before the playoffs. Even if the Bills rest some players in this game, they have a lot more talent than the Jets in their current state, so look for the Bills to roll here. The best way to place a bet here is on the Bills to cover the spread in this game. 

Jets Bills Prediction:  Our NFL Pick for Sunday, January 4, 2026 (4:25 pm ET start time) is Bills 20 Jets 6.
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NFL Betting Trends


New York Jets: 19-29 ATS in all games. 8-19 ATS in all games where the total is between 35.5 and 42 points. 4-10 ATS after a loss by 14 or more points. 6-3 OVER after 3 or more consecutive losses against the spread. 6-3 OVER when playing against a good team (Win Pct. 60% to 75%).

Buffalo Bills: 7-3 ATS off an upset loss as a favorite. 9-5 ATS after 1 or more consecutive losses. 9-4 ATS versus good rushing teams - averaging 4.5 rushing yards/carry or more. 7-1 OVER in all games where the total is between 35.5 and 42 points. 11-4 OVER after allowing 14 points or less last game.

Key Injuries


New York Jets:  None.

Buffalo Bills:  None.

Notable Quotes


“Highly, highly disappointed in the way that we came out. Today was probably the one time I feel like our effort wasn’t as good as I want it to be.” - Aaron Glenn after his team’s loss against the Patriots in their last game. 


“Yeah, it means a lot. We can learn a lot from this experience. I’d rather have won and learn from that too, but again, I got to make a play.” - Josh Allen after their loss against the Eagles in their last game. 


Starting Lineups


New York Jets
WR Mitchell, Adonai
WR Metchie III, John
WR Williams, Isaiah
TE Ruckert, Jeremy
QB Cook, Brady
RB Hall, Breece
FB Beck, Andrew

Buffalo Bills
WR Palmer, Joshua
WR Shavers, Tyrell
WR Shakir, Khalil
TE Knox, Dawson
QB Allen, Josh
RB Cook, James
FB Gilliam, Reggie

Statistical Leaders


New York Jets
Passing: Justin Fields (1,259)
Rushing: Breece Hall (1,065)
Receiving: Garrett Wilson (395)
Touchdowns: Breece Hall (5)

Buffalo Bills
Passing: Josh Allen (3,668)
Rushing: James Cook (1,606)
Receiving: Khalil Shakir (719)
Touchdowns: James Cook (14)

Coaches:
New York Jets: Aaron Glenn (1st season)
Buffalo Bills: Sean McDermott (9th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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