by Rod Pearson
Tuesday, Sep 19, 2023
Game Time: 8:15 pm ET, Thursday, September 21, 2023
Venue: Levi's Stadium, Santa Clara, CA
Where to Watch: Amazon Prime Video
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Giants +10.5, 49ers -10.5; Over/Under: 45.5 points
Bet365: Point Spread: Giants +10.5, 49ers -10.5; Over/Under: 45 points
BetMGM: Point Spread: Giants +10.5, 49ers -10.5; Over/Under: 45.5 points
Season Record
New York Giants: 1-1 (4th place, NFC East)
San Francisco 49ers: 2-0 (1st place, NFC West)
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New York Giants: won their last game on the road against the Arizona Cardinals 31-28.
San Francisco 49ers: won their last game on the road against the Los Angeles Rams 30-23.
New York Giants vs San Francisco 49ers Preview and Analysis
The Giants are entering this game with a 1-1 record overall and they have a 0-1 record in their divisional games too. They are 0-1 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Arizona Cardinals 31-28. Daniel Jones was the starting QB and he completed 26/37 passes for 321 passing yards, 2 touchdowns, and 1 interception. Saquon Barkley led the team in rushing yards with 63 and 1 TD. Jalin Hyatt led the receivers with 89 receiving yards on 2 receptions. Jason Pinnock led the defense in that game with 10 solo tackles and 3 assisted tackles while no one on the defense recorded a sack in that one. No one on the defense came away with an interception in that game.
The 49ers are entering this game with a 2-0 record overall and they have a 1-0 record in their divisional games too. They are 0-0 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the LA Rams 30-23. Brock Purdy was the starting QB and he completed 17/25 passes for 206 passing yards, 0 touchdowns, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 116 and 1 TD. Deebo Samuel led the receivers with 63 receiving yards on 6 receptions. Fred Warner led the defense in that game with 9 solo tackles and 2 assisted tackles while Fred Warner led the defense in sacks with 1. Deommodore Lenoir and Isaiah Oliver each came away with 1 interception for them in that game.
Giants vs 49ers Prediction
The current betting odds have the 49ers listed as a 10.5 point favorite in this game according to Draftkings Sportsbook. The 49ers have looked really good in their 2 games as they destroyed the Steelers on the road and then won another road game against a better Rams team in a divisional game. Now they come back home for their home opener and the Giants will have some momentum as they finally won their 1st game of the season last week. That was a big win for them as they were shut out by the Cowboys in week 1 and then were down 28-0 against the Cardinals, one of the worst teams in the NFL, but fought back in the 2nd half to come back and win. That win took a lot out of the Giants though and now they are going to be on a short week in another road game and this time they are getting a Super Bowl caliber team. The Giants have struggled on offense in both of their games and they are going to struggle here since the 49ers have one of the best defenses in the league. The 49ers also have a lot more talent on offense and the Giants won't be able to put the points up like the 49ers can. The best way to place a bet here is on the 49ers to cover the spread in this game.
Giants 49ers Prediction: Our NFL Pick for Thursday, September 21, 2023 (8:15 pm ET start time) is 49ers 31 Giants 10.
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NFL Betting Trends
New York Giants: 0-3 ATS against NFC West division opponents. 2-4 ATS after a playing a game where 50 total points or more were scored. 19-10 UNDER as an underdog. 16-8 UNDER as an underdog of 10 or more points. 13-7 UNDER in all games where the total is between 42.5 and 49 points.
San Francisco 49ers: 26-15 ATS in all games. 12-5 ATS as a home favorite. 21-9 ATS against conference opponents. 5-1 UNDER as a home favorite of 7.5 to 14 points. 9-4 UNDER off a division game.
Key Injuries
New York Giants: S. Barkley (RB) day-to-day - Ankle. A. Ojulari (LB) day-to-day - Hamstring. A. Thomas (OT) day-to-day - Hamstring. W. Robinson (WR) day-to-day - Knee. G. Owens (DB) day-to-day - Hamstring. T. Sweeney (TE) Out indefinitely - Illness. A. Robinson (CB) Out indefinitely - Knee. C. Myarick (FB) I-R - Hand. B. Ford-Wheaton (WR) I-R - Knee. J. Hassenauer (OL) I-R - Tricep. J. Davis (LB) I-R - Knee.
San Francisco 49ers: S. Womack III (CB) Out indefinitely - Knee. R. Beal Jr. (DL) Out indefinitely - Hamstring. D. Gray (WR) Out indefinitely - Shoulder. D. Luter Jr. (CB) Out indefinitely - Knee. C. Latu (TE) I-R - Knee.
Notable Quotes
“I think we have some mentally tough players on our team, and coaches. It's not always easy to be mentally tough when you're down 60-0 after a game and a half.” - Brian Daboll after his team’s win against the Cardinals in their last game.
“I feel like those guys, a lot of them, you don't know them, but they're on that team for a reason. Those guys are trying to make a name for themselves, and they played hard for four quarters. We knew we were going to get their best shot.” - Brock Purdy after their win against the Rams in their last game.
Starting Lineups
New York Giants
WR Hodgins, Isaiah
WR Slayton, Darius
WR Campbell, Parris
TE WALLER, DARREN
QB Jones, Daniel
RB Barkley, Saquon
San Francisco 49ers
WR Aiyuk, Brandon
WR Samuel, Deebo
WR Jennings, Jauan
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB JUSZCZYK, KYLE
Statistical Leaders
New York Giants
Passing: D. Jones (425)
Rushing: S. Barkley (114)
Receiving: D. Waller (112)
Touchdowns: S. Barkley (2)
San Francisco 49ers
Passing: B. Purdy (426)
Rushing: C. McCaffrey (268)
Receiving: B. Aiyuk (172)
Touchdowns: B. Aiyuk (2)
Coaches:
New York Giants: Brian Daboll (2nd season)
San Francisco 49ers: Kyle Shanahan (7th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
