by Rod Pearson
Friday, Sep 18, 2026
Game Time: 8:15 pm ET, Monday, September 21, 2026
Venue: SoFi Stadium, Inglewood, CA
Where to Watch: ESPN, ABC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Giants +7, Rams -7; Over/Under: 48.5 points
Bet365: Point Spread: Giants +7, Rams -7; Over/Under: 48 points
BetMGM: Point Spread: Giants +7, Rams -7; Over/Under: 48 points
Season Record
New York Giants: 1-0 (1st place, NFC East)
Los Angeles Rams: 0-1 (4th place, NFC West)
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New York Giants: won their last game at home against the Dallas Cowboys 28-20.
Los Angeles Rams: lost their last game at a neutral site against the San Francisco 49ers 27-7.
New York Giants vs Los Angeles Rams Preview and Analysis
The Giants are entering this game with a 1-0 record overall and they have a 1-0 record in their divisional games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Dallas Cowboys 28-20. Jaxson Dart was the starting QB and he completed 23/29 passes for 230 passing yards, 3 touchdowns, and 0 interceptions. Cameron Skattebo led the team in rushing yards with 81 and 1 TD. Isaiah Likely led the receivers with 78 receiving yards on 8 receptions and 2 TDs. Tremaine Edmunds led the defense in that game with 8 solo tackles while no one on the defense recorded a sack for them. Jevon Holland came away with the only interception for them in that one.
The Rams are entering this game with a 0-1 record overall and they have a 0-1 record in their divisional games too. They are 0-0 in their home games, 0-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They lost their last game against the San Francisco 49ers 27-7. Matthew Stafford was the starting QB and he completed 15/25 passes for 155 passing yards, 0 touchdowns, and 1 interception. Blake Corum led the team in rushing yards with 54. Puka Nacua led the receivers with 74 receiving yards on 5 receptions. Quentin Lake led the defense in that game with 10 solo tackles while no one on the defense recorded a sack for them. Quentin Lake came away with the only interception for them in that one.
Giants vs Rams Prediction
The current betting odds have the Giants listed as a 7 point underdog in this game according to Draftkings Sportsbook. The Giants have looked good in their games this season with their 1-0 record overall and their 1-0 record in the division. They haven't played any road games though and will be playing their 1st road game of the season here. Meanwhile, the Rams haven't looked good in their games this season with their 0-1 record overall and their 0-1 record in their division. They haven't played any home games though and will be playing their home opener here. The Rams are coming off a 27-7 loss to the 49ers in week 1 and they looked terrible in that game. The game was in Australia and they didn't have the best travel plans, but they still have one of the most talented rosters in the NFL, being the Super Bowl favorites, but they looked terrible in every facet. They will be looking to bounce back at home now, but this is no easy task for them and they are likely still feeling repercussions from the trip to Australia. The Giants looked great in week 1, beating the Cowboys 28-20. They were in control of that game from start to finish and looked a lot better with a competent head coach now. Harbaugh is bringing a winning culture to New York and the team does have plenty of talent with the way they have drafted the last few years. The Giants are looking to make a big statement with their new head coach this season and they have the chance to make one here in prime time against the Super Bowl favorites who looked like they weren't ready for the season to start in week 1. The Rams will likely bounce back to win this game, but the Giants are catching the Rams in a good situation here and have the talent to keep this close. The best way to place a bet here is on the Giants to cover the spread in this game.
Giants Rams Prediction: Our NFL Pick for Monday, September 21, 2026 (8:15 pm ET start time) is Rams 28 Giants 24.
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NFL Betting Trends
New York Giants: 13-20 ATS in all games. 5-11 ATS in all games where the total is between 42.5 and 49 points. 8-15 ATS against conference opponents. 4-1 UNDER off a upset win as an underdog. 7-2 UNDER in the first month of the regular season.
Los Angeles Rams: 4-0 ATS off an upset loss as a favorite. 4-0 ATS after scoring 14 points or less last game. 8-4 ATS after 1 or more consecutive losses. 7-1 UNDER as a home favorite of 7 points or less.
Key Injuries
New York Giants: P. Adebo (CB) Injured - Knee. D. Banks (CB) Injured - Calf. C. Golston (DL) Injured - Neck. F. Mauigoa (OG) Injured - Shoulder. M. McFadden (LB) Injured - Neck. G. Newsome II (CB) Injured - Rib. A. Thomas (OT) Injured - Ankle.
Los Angeles Rams: O. Speights (LB) Injured - Hip. N. Landman (LB) Injured - Shoulder. K. Kinchens (S) Injured - Hamstring. D. Adams (WR) Injured - Rest. K. Curl (S) Injured - Ankle.
Notable Quotes
“He's just a guy where no matter what the coverage is, no matter who they put out there on him, you have all the confidence in the world that he's going to make a play.” - Jaxson Dart on Malik Nabers after their win against the Cowboys in their last game.
“I know there’s gonna be a lot of narratives that appropriately put the blame on me, and then we’ll move forward the right way. I don’t believe (the travel plan) is why we didn’t play well enough. I really don’t.” - Sean McVay after his team’s loss against the 49ers in their last game.
Starting Lineups
New York Giants
WR Nabers, Malik
WR Fields, Malachi
WR Mooney, Darnell
TE Likely, Isaiah
QB Dart, Jaxson
RB Skattebo, Cam
FB Ricard, Patrick
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Whittington, Jordan
TE Parkinson, Colby
QB Stafford, Matthew
RB Williams, Kyren
Statistical Leaders
New York Giants
Passing: Jaxson Dart (230)
Rushing: Cam Skattebo (81)
Receiving: Isaiah Likely (78)
Touchdowns: Isaiah Likely (2)
Los Angeles Rams
Passing: Matthew Stafford (155)
Rushing: Blake Corum (54)
Receiving: Puka Nacua (74)
Touchdowns: Kyren Williams (1)
Coaches:
New York Giants: John Harbaugh (1st season)
Los Angeles Rams: Sean McVay (10th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
