by Rod Pearson
Tuesday, Nov 18, 2025
Game Time: 1:00 pm ET, Sunday, November 23, 2025
Venue: Ford Field, Detroit, MI
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Giants +10.5, Lions -10.5; Over/Under: 49.5 points
Bet365: Point Spread: Giants +10.5, Lions -10.5; Over/Under: 49.5 points
BetMGM: Point Spread: Giants +10.5, Lions -10.5; Over/Under: 50 points
Season Record
New York Giants: 2-9 (4th place, NFC East)
Detroit Lions: 6-4 (3rd place, NFC North)
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Recent Form
New York Giants: lost their last game at home against the Green Bay Packers 27-20.
Detroit Lions: lost their last game on the road against the Philadelphia Eagles 16-9.
New York Giants vs Detroit Lions Preview and Analysis
The Giants are entering this game with a 2-9 record overall and they have a 1-3 record in their divisional games too. They are 2-3 in their home games, 0-6 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Green Bay Packers 27-20. Jameis Winston was the starting QB and he completed 19/29 passes for 201 passing yards, 0 touchdowns, and 1 interception. Tyrone Tracy Jr. led the team in rushing yards with 88. Isaiah Hodgins led the receivers with 57 receiving yards on 5 receptions. Bobby Okereke led the defense in that game with 6 solo tackles and 1 assisted tackle while Brian Burns led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.
The Lions are entering this game with a 6-4 record overall and they have a 1-2 record in their divisional games too. They are 3-1 in their home games, 3-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Philadelphia Eagles 16-9. Jared Goff was the starting QB and he completed 14/37 passes for 255 passing yards, 1 touchdown, and 1 interception. Jahmyr Gibbs led the team in rushing yards with 39. Jahmyr Gibbs led the receivers with 107 receiving yards on 5 receptions. Jack Campbell led the defense in that game with 7 solo tackles and 8 assisted tackles while Aidan Hutchinson and Roy Lopez each led the defense in sacks with 0.5. No one on the defense came away with an interception for them in that one.
Giants vs Lions Prediction
The current betting odds have the Lions listed as a 10.5 point favorite in this game according to Draftkings Sportsbook. The Lions have looked good in their games this season with their 6-4 record overall, but that record has them near the bottom of the NFC North in a competitive division. They are off a 16-9 loss to the Eagles in their last one, but they will be looking to bounce back at home after losing to one of the best teams in the NFL. Meanwhile, the Giants have looked terrible in their games this season with their 2-9 record overall which has them right at the bottom of the NFC East with one of the worst record in the entire NFL. The future is looking bright for the Giants with the exciting young players they have, but a lot of those players are out with injuries in what has been a disaster of a season. Jameis Winston got the start last week in place of an injured Dart and the offense had some life early on, but the Giants defense blew another lead and that has been the story of the season. Their season is pretty much over and they have been a terrible road team this year with their 0-6 road record. This is a bad situation for the Giants to go on the road against a much better Lions team that is going to be angry from their loss to the Eagles. The Lions always find a way to bounce back big off a loss so look for the to roll a bad Giants team here. The best way to place a bet here is on the Lions to cover the spread in this game.
Giants Lions Prediction: Our NFL Pick for Sunday, November 23, 2025 (1:00 pm ET start time) is Lions 45 Giants 10.
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NFL Betting Trends
New York Giants: 17-25 ATS in all games. 6-13 ATS after playing a game at home. 4-8 ATS vs. good passing teams averaging 7 or more passing yards/att. 10-6 OVER when playing against a good team (Win Pct. 60% to 75%).
Detroit Lions: 32-16 ATS in all games. 27-12 ATS as a favorite. 22-12 ATS against conference opponents. 7-2 ATS vs. bad defensive teams who give up 24 or more points/game. 7-2 OVER vs. bad defensive teams who give up 24 or more points/game.
Key Injuries
New York Giants: R. Nunez-Roches Sr. (DL) Injured - Toe. D. Flannigan-Fowles (LB) Injured - Illness. D. Slayton (WR) Injured - Hamstring. C. Golston (DL) Injured - Neck. P. Adebo (CB) Injured - Knee. C. Flott (CB) Injured - NIR - Personal. D. Banks (CB) Injured - Hip. K. Thibodeaux (LB) Injured - Shoulder. E. Gray (RB) Injured - Knee. R. Payton (CB) Injured - Illness. T. Nubin (S) Injured - Neck. T. Fidone II (TE) Injured - Foot. J. Dart (QB) Injured - Concussion.
Detroit Lions: T. Decker (OT) Injured - Shoulder. G. Glasgow (OG) Injured - Knee. K. Raymond (WR) Injured - Cramping. M. Davenport (DL) Injured - Shoulder. D. Reed (CB) Injured - Hamstring. J. Paschal (DL) Injured - Back. B. Wright (TE) Injured - Ankle. M. Rodriguez (LB) Injured - Knee. J. Saylors (RB) Injured - Back. P. Sewell (OT) Injured - Ankle. K. Joseph (S) Injured - Knee. B. Branch (CB) Injured - Toe. T. Arnold (CB) Injured - Concussion. S. Vaki (RB) Injured - Ankle. M. Frazier (OG) Injured - Knee. I. TeSlaa (WR) Injured - Oblique. T. Ratledge (OG) Injured - Knee.
Notable Quotes
“I really wanted to get a win for these guys. Unfortunately we finished the way we did, but (Kafka) brought great energy. We have that leader who has that player perspective.” - Jameis Winston after their loss against the Packers in their last game.
“They’re a good ... defense.” - Jared Goff after their loss against the Eagles in their last game.
Starting Lineups
New York Giants
WR Hodgins, Isaiah
WR Hyatt, Jalin
WR Robinson, Wan'Dale
TE Johnson, Theo
QB Winston, Jameis
RB Tracy Jr., Tyrone
Detroit Lions
WR Williams, Jameson
WR St. Brown, Amon-Ra
WR Raymond, Kalif
TE Wright, Brock
QB Goff, Jared
RB Gibbs, Jahmyr
Statistical Leaders
New York Giants
Passing: Jaxson Dart (1,417)
Rushing: Cam Skattebo (410)
Receiving: Wan'Dale Robinson (638)
Touchdowns: Cam Skattebo (7)
Detroit Lions
Passing: Jared Goff (2,490)
Rushing: Jahmyr Gibbs (732)
Receiving: Amon-Ra St. Brown (735)
Touchdowns: Jahmyr Gibbs (10)
Coaches:
New York Giants: Mike Kafka (Interim)
Detroit Lions: Dan Campbell (5th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
