New York Giants vs Buffalo Bills Prediction, Preview and Odds - 10/15/2023

by Rod Pearson

Thursday, Oct 12, 2023
Game Time: 8:20 pm ET, Sunday, October 15, 2023
Venue:  Highmark Stadium, Orchard Park, NY
Where to Watch:  NBC


Opening Odds at USA Sportsbooks

DraftKings:  Point Spread:  Giants +14, Bills -14; Over/Under:  44.5 points
Bet365:  Point Spread:  Giants +14, Bills -14; Over/Under:  45 points
BetMGM:  Point Spread:  Giants +14, Bills -14; Over/Under:  44.5 points

Season Record

New York Giants:  1-4 (4th place, NFC East)
Buffalo Bills:  3-2 (2nd place, AFC East)

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Recent Form
New York Giants:  lost their last game on the road against the Miami Dolphins 31-16.
Buffalo Bills:  lost their last game at a neutral site against the Jacksonville Jaguars 25-20.


New York Giants vs Buffalo Bills Preview and Analysis


The Giants are entering this game with a 1-4 record overall and they have a 0-1 record in their divisional games too. They are 0-2 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Miami Dolphins 31-16. Daniel Jones was the starting QB and he completed 14/20 passes for 119 passing yards, 0 touchdowns, and 0 interceptions. Eric Gray led the team in rushing yards with 25. Darren Waller led the receivers with 86 receiving yards on 8 receptions. Isaiah Simmons led the defense in that game with 7 solo tackles and 2 assisted tackles while Kayvon Thibodeaux led the defense in sacks with 1. Bobby Okereke and Jason Pinnock each came away with 1 interception for them in that game.
 
 
 
The Bills are entering this game with a 3-2 record overall and they have a 1-1 record in their divisional games too. They are 2-1 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Jacksonville Jaguars 25-20. Josh Allen was the starting QB and he completed 27/40 passes for 359 passing yards, 2 touchdowns, and 1 interception. Josh Allen led the team in rushing yards with 14 and 1 TD. Stefon Diggs led the receivers with 121 receiving yards on 8 receptions and 1 TD. Terrel Bernard led the defense in that game with 8 solo tackles and 8 assisted tackles while A.J. Epenesa and Leonard Floyd each led the defense in sacks with 2. No one on the defense came away with an interception for them in that game.


Giants vs Bills Prediction

The current betting odds have the Bills listed as a 14 point favorite in this game according to Draftkings Sportsbook. The Bills are only 3-2 this season and were looking really good in their games up until they lost last week in London to the Jags. The Bills were not well prepared for that game as they left for England really late in the week and were coming off a big emotional win against the Dolphins. Now the Bills are coming back from England for this game but they are going to be looking to bounce back at home after an embarrassing loss to the Jags overseas. The Giants have also been terrible this season with their 1-4 record overall and they have not been able to get anything going without Barkley in their lineup. Even if Barkley plays in this game, they still have a terrible defense that has been getting burned in every game all season and they won't be able to stop this Bills offense looking to bounce back here at home. The best way to place a bet here is on the Bills to cover the spread in this game. 

Giants Bills Prediction:  Our NFL Pick for Sunday, October 15, 2023 (8:20 pm ET start time) is Bills 35 Giants 16.
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NFL Betting Trends


New York Giants: 3-6 ATS as a road underdog of 7.5 to 14 points. 5-10 ATS after 3 straight losses by 10 or more points. 25-14 UNDER in all games. 22-10 UNDER as an underdog. 6-0 UNDER off a road blowout loss by 14 points or more.

Buffalo Bills: 8-3 ATS as a home favorite of 10.5 to 14 points. 21-13 ATS against NFC East division opponents. 9-3 ATS after gaining 350 or more passing yards in the last game. 8-3 UNDER as a favorite of 10 or more points. 24-15 UNDER as a favorite. 

Key Injuries


New York Giants:  C. Flott (DB) Ques Sun - Ankle. G. Brightwell (RB) Ques Sun - Ankle. D. Banks (CB) Ques Sun - Ankle. M. Peart (OT) Ques Sun - Shoulder. A. Ojulari (LB) Ques Sun - Ankle. W. Robinson (WR) Ques Sun - Knee. D. Waller (TE) Ques Sun - Groin. S. Barkley (RB) Late Oct - Ankle. A. Thomas (OT) Ques Sun - Hamstring. J. Schmitz (OL) Ques Sun - Shoulder. S. Lemieux (G) Ques Sun - Groin. M. McFadden (LB) Ques Sun - Ankle. D. Jones (QB) Ques Sun - Neck. M. McKethan (OL) Ques Sun - Knee. G. Owens (DB) Out indefinitely - Hamstring. T. Sweeney (TE) Out indefinitely - Illness. A. Robinson (CB) Out indefinitely - Knee. C. Myarick (FB) I-R - Hand. B. Ford-Wheaton (WR) I-R - Knee. J. Hassenauer (OL) I-R - Tricep. J. Davis (LB) I-R - Knee.

Buffalo Bills:  D. Jones (DT) I-R - Pectoral. B. Spector (LB) Ques Sun - Hamstring. S. Lawson (DE) Prob Sun - Toe. C. Benford (CB) Prob Sun - Shoulder. D. Jackson (CB) Ques Sun - Foot. M. Milano (LB) I-R - Leg. G. Rousseau (DE) Ques Sun - Foot. D. Knox (TE) Ques Sun - Wrist. D. Kincaid (TE) Ques Sun - Concussion. T. White (CB) I-R - Achilles. J. Shorter (WR) Out indefinitely - Hamstring. T. Doyle (OT) I-R - Knee. Z. Davidson (TE) I-R - Knee. N. Hines (RB) I-R - Knee.

Notable Quotes


“We’ve got to figure out a way to protect him better.” - Brian Daboll on Daniel Jones after his team’s loss against the Dolphins in their last game. 


“We didn’t take care of the little things. That’s on us captains, making sure that this team is ready to go. You know, the opposing team, they were ready to go today. We weren’t.” - Josh Allen after their loss against the Jaguars in their last game. 


Starting Lineups


New York Giants
WR Hyatt, Jalin 
WR Slayton, Darius 
WR Robinson, Wan'Dale 
TE WALLER, DARREN 
QB Jones, Daniel 
RB Barkley, Saquon 

Buffalo Bills
WR Davis, Gabe 
WR Diggs, Stefon 
WR Shakir, Khalil  
TE Knox, Dawson 
QB Allen, Josh 
RB Cook, James 
FB Gilliam, Reggie

Statistical Leaders


New York Giants
Passing: D. Jones (884)
Rushing: D. Jones (197)
Receiving: D. Waller (239)
Touchdowns: S. Barkley (2)

Buffalo Bills
Passing: J. Allen (1407)
Rushing: J. Cook (292)
Receiving: S. Diggs (520)
Touchdowns: S. Diggs (5)

Coaches:
New York Giants: Brian Daboll (2nd season)
Buffalo Bills: Sean McDermott (7th season)


Rod Pearson

About the Author:

Rod Pearson has been a rabid sports fan his entire life.  He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years.  In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective.  Join Rod every day as he breaks down the games to find the best betting value.

All photographic images used for editorial content have been licensed from the Associated Press.

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