Morehead State Eagles vs Louisville Cardinals Prediction, Picks and Game Preview - 11/07/2026

Game Time: 12:00 pm ET, Saturday, November 7, 2026

Venue:  KFC Yum! Center, Louisville, KY

Where to Watch:  ACCNX

DraftKings:  Point Spread:  Morehead State +36.5, Louisville -36.5; Over/Under:  150 points

Bet365:  Point Spread:  Morehead State +36.5, Louisville -36.5; Over/Under:  150 points

BetMGM:  Point Spread:  Morehead State +36.5, Louisville -36.5; Over/Under:  150 points

Morehead State Eagles:  1-1 (0-0) (3rd place, OVC)

Louisville Cardinals:  1-0 (0-0) (8th place, ACC)

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Morehead State Eagles:  1-1  last 2

Louisville Cardinals:  1-0  last 1

Morehead State is entering this game with a 1-1 record overall, a 0-0 record in conference games, and they are 0-1 in their road games this season where they will be in this game. They are coming off a win against the Virginia University of Lynchburg Dragon in their last game. Kyrell Shaw led the team in points in that game with 28 while Clayton Parker was next on the team with 24. Jarvis Wright led the team in assists with 8 in that game while Dalman Alexander and Tayvion Tangiora each led the team in rebounds with 10. They were 60.3% from the field, 48.4% from 3-point range, and 68.8% from the free throw line with their shooting in that game. Their offense is averaging 86 PPG and their defense is allowing their opponents to average 71.5 PPG against them. Morehead State has an ATS record of 0-1 this season and their O/U record is 0-1.

Louisville is entering this game with a 1-0 record overall, a 0-0 conference record, and they are 1-0 in their home games this season where they will be in this game. They are coming off a win against the Chattanooga Mocs in their last game. Flory Bidunga led the team in points in that game with 16 while Adrian Wooley was next on the team with 15. Seth Trimble led the team in assists with 5 in that game while Karter Knox led the team in rebounds with 11. They were 44.1% from the field, 25.7% from 3-point range, and 57.7% from the free throw line with their shooting in that game. Their offense is averaging 84 PPG and their defense is allowing their opponents to average 70 PPG against them. Louisville has an ATS record of 0-1 this season and their O/U record is 0-1.

The current betting odds have Morehead State listed as a 36.5 point underdog in this game according to Draftkings Sportsbook. Morehead State already has 2 games under their belt this season and they are 1-1 in those. They lost their season opener to Western Kentucky and they looked terrible in that one. They got blown out by over 20 points and they couldn't really put up points, but now they are coming off a feel good win over a team that doesn't play in Division I. Meanwhile, Louisville has only played 1 game this season and they won that one at home, but they weren't nearly as dominant as they should have been. Their offense was great and they still won the game over Chattanooga by double digits, but their defense wasn't good. They gave up 70 points in that win and they weren't playing against a team on their level either. Louisville was a top 25 team for most of the season last year and they have a lot more talent than Morehead State has, but Morehead State will be able to put up points here coming off their 1st win putting up over 100 points. Louisville will be looking to tighten up their defense and they will likely still win this game by double digits, but this is a lot of points for a team that wasn't that convincing on defense in their season opener against a much weaker opponent. The best way to place a bet here is on Morehead State to cover the spread in this game.

Morehead State Louisville Prediction:  Our NCAAB Pick for Saturday, November 7, 2026 (12:00 pm ET start time) is Louisville 96 Morehead State 68.

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Morehead State Eagles: 14-5 ATS off a home win. 16-8 ATS when playing their 2nd game in 3 days. 18-11 UNDER as a road underdog or pick. 5-0 UNDER off a home blowout win by 20 points or more. 21-11 UNDER after playing a road game.

Louisville Cardinals: 4-9 ATS in a home game where the total is 150 to 159.5. 44-27 UNDER in all games. 18-10 UNDER as a favorite of 10 or more points. 20-6 UNDER when the total is 150 to 159.5. 33-18 UNDER after 1 or more consecutive wins.

Morehead State Eagles:  None.

Louisville Cardinals:  D. Montgomery (G) Out - Undisclosed. G. Dynes (C) Out - Shoulder.

"They've got good players across the board. Tough challenge for us. I'll have some goals going into that game of what I would like to see us do and accomplish ... and we're going to go and give it everything we've got." - Jonathan Mattox on his team’s upcoming game against Louisville. 

"Our first half was really, really good on both ends. And really good teams are consistent, still elite on defense and rebounding, regardless of whether the ball is going in. We've got such high standards and expectations for this team, and we've got phenomenal leadership, like great leadership. Our best players are our hardest workers. They'll respond to this." - Pat Kelsey on his team’s upcoming game against Morehead State.

D. Alexander 

C. Dawson 

V. Dawson 

I. Day 

C. Parker

F. Bidunga 

Á. Folgueiras 

J. Shelstad 

S. Trimble 

A. Wooley

PPG: Clayton Parker (18)

APG: Jarvis Wright (4.5)

Reb/G: Tayvion Tangiora (8.5)

PPG: Flory Bidunga (16)

APG: Seth Trimble (5)

Reb/G: Karter Knox (11)

Coaches:

Morehead State Eagles: Jonathan Mattox (3rd season)

Louisville Cardinals: Pat Kelsey (3rd season)