Missouri Tigers vs Oklahoma Sooners Prediction, Picks and Game Preview - 11/22/2025

Game Time: 12:00 pm ET, Saturday, November 22, 2025

Venue:  Gaylord Family - Oklahoma Memorial Stadium, Norman, OK

Where to Watch:  ABC

DraftKings:  Point Spread:  Mizzou +9.5, Oklahoma -9.5; Over/Under:  42.5 points

Bet365:  Point Spread:  Mizzou +9.5, Oklahoma -9.5; Over/Under:  42.5 points

BetMGM:  Point Spread:  Mizzou +9.5, Oklahoma -9.5; Over/Under:  42.5 points

Missouri Tigers:  7-3 (3-3) (9th place, SEC)

Oklahoma Sooners:  8-2 (4-2) (6th place, SEC)

Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in college football on an 8-1 CFB RUN for +$6,900 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Missouri Tigers:  won their last game at home against the Mississippi State Bulldogs 49-27.

Oklahoma Sooners:  won their last game on the road against the Alabama Crimson Tide 23-21.

Missouri is entering this game with a 7-3 record overall and they have a 3-3 record in their conference games too. They are 6-2 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Mississippi State 49-27. Matt Zollers was the starting QB and he completed 8/15 passes for 112 passing yards, 2 touchdowns, and 1 interception. Ahmad Hardy led the team in rushing yards with 300 and 3 TDs. Kevin Coleman Jr. led the receivers with 41 receiving yards on 4 receptions. Khalil Jacobs led the defense in that game with 6 solo tackles and 4 assisted tackles while Darris Smith led the defense in sacks with 2. Marvin Burks Jr. and Toriano Pride Jr. each came away with 1 interception for them in that one.

 

 

 

Oklahoma is entering this game with an 8-2 record overall and they have a 4-2 record in their conference games too. They are 4-1 in their home games, 4-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against Alabama 23-21. John Mateer was the starting QB and he completed 15/23 passes for 138 passing yards, 0 touchdowns, and 0 interceptions. Xavier Robinson led the team in rushing yards with 34. Jer'Michael Carter led the receivers with 36 receiving yards on 3 receptions. Kip Lewis led the defense in that game with 7 solo tackles and 0 assisted tackles while Kip Lewis led the defense in sacks with 2. Eli Bowen came away with the only interception for them in that one.

The current betting odds have Oklahoma listed as a 9.5 point favorite in this game according to Draftkings Sportsbook. Oklahoma has looked great in their games this season with their 8-2 record overall and their 4-2 conference record which has them in the top half of the SEC. Their 2 conference losses will likely keep them out of the SEC Championship in a competitive race at the top, but they are ranked inside the top 15 and have looked like a playoff team all year. Meanwhile, Missouri has looked good in their games this season with their 7-3 record overall, but their 3-3 conference record has them right in the middle of the SEC. They are ranked inside the top 25, but they haven't been the same team since losing their starting QB to injury and their playoff hopes have definitely come to an end with those 3 losses. They are off a 49-27 win over Mississippi State in their last one, but they beat up on one of the worst teams in the conference and have also looked a lot better on their home field all year. They are going to be on the road now and they have only played 2 road games this season, going 1-1 in those. Oklahoma still has some playoff hopes though so they are going to bring their best effort for another ranked team at home, and Oklahoma has been rolling in their games lately. They pulled off an upset win over Tennessee on the road and now they have a ton of momentum on their side, off a 23-21 road win over Alabama in their last one. Missouri has a great offense, but it hasn't been the same with their backup QB so they are going to struggle on the road against one of the best defenses in the SEC, and Missouri's own defense hasn't looked great this season either. The best way to place a bet here is on Oklahoma to cover the spread in this game. 

Missouri Oklahoma Prediction:  Our NCAAF Pick for Saturday, November 22, 2025 (12:00 pm ET start time) is Oklahoma 27 Missouri 13.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Missouri Tigers Oklahoma Sooners prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Missouri Tigers: 24-12 ATS in all lined games. 8-3 ATS in road lined games. 5-0 ATS vs. good defensive teams who give up 17 or less points/game. 8-4 UNDER after a win by 17 or more points. 

Oklahoma Sooners: 4-8 ATS off a win against a conference rival. 4-7 ATS when playing against a good team (Win Pct. 60% to 75%). 2-5 ATS after a game with a turnover margin of +2 or better. 6-2 UNDER versus good rushing teams - averaging 200  rushing yards/game or more.

Missouri Tigers:  L. Kitchen (DL) Questionable - Undisclosed. B. Pribula (QB) Questionable - Ankle. S. Horn (QB) Out - Leg. B. Craig (K) Out - Undisclosed.

Oklahoma Sooners:  J. Barnes (RB) Questionable - Undisclosed. J. Sexton (OG) Questionable - Undisclosed. J. Taylor (OG) Questionable - Undisclosed. G. Williams (CB) Questionable - Undisclosed. K. Dolby (CB) Questionable - Undisclosed. T. Tatum (RB) Questionable - Undisclosed. T. Everett (OG) Out - Undisclosed.

“I thought the o-line and tight ends obviously prevented penetration, allowed him to get to the second level, but then he did the rest. Once the holes started, they were playing quite a bit of man to man, which prevents overlapping the defense, and I think his speed really surprised them.” - Eli Drinkwitz after his team’s win against MS State in their last game. 

"They give us a spark whenever we need it. They didn't get a whole lot of turnovers at the beginning of the year, but the football gods loved them back because of how hard they play." - John Mateer after their win against Alabama in their last game. 

WR Johnson, Marquis

WR Manning, Joshua

WR Coleman Jr., Kevin

TE Norfleet, Brett

QB Zollers, Matt

RB Hardy, Ahmad

WR Lewis, Keontez

WR Burks, Deion

WR Sategna III, Isaiah

TE Kanak, Jaren

QB Mateer, John

RB Blaylock, Tory

Passing: Beau Pribula (1,685)

Rushing: Ahmad Hardy (1,346)

Receiving: Kevin Coleman Jr. (600)

Touchdowns: Ahmad Hardy (15)

Passing: John Mateer (2,087)

Rushing: Tory Blaylock (402)

Receiving: Isaiah Sategna III (718)

Touchdowns: John Mateer (7)

Coaches:

Missouri Tigers: Eli Drinkwitz (6th season)

Oklahoma Sooners: Brent Venables (4th season)