Missouri Tigers vs Mississippi Rebels Prediction, Picks and Game Preview - 10/17/2026

Game Time: 3:30 pm ET, Saturday, October 17, 2026

Venue:  Vaught Hemingway Stadium, Oxford, MS

Where to Watch:  SEC Network

DraftKings:  Point Spread:  Mizzou +6, Ole Miss -6; Over/Under:  59.5 points

Bet365:  Point Spread:  Mizzou +6, Ole Miss -6; Over/Under:  59.5 points

BetMGM:  Point Spread:  Mizzou +5.5, Ole Miss -5.5; Over/Under:  58.5 points

Missouri Tigers:  5-1 (2-1) (5th place, SEC)

Mississippi Rebels:  4-1 (2-1) (7th place, SEC)

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Missouri Tigers:  won their last game at home against the Texas A&M Aggies 27-6.

Mississippi Rebels:  won their last game on the road against the Vanderbilt Commodores 52-17.

Missouri is entering this game with a 5-1 record overall and they have a 2-1 record in their conference games too. They are 4-0 in their home games, 1-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Texas A&M 27-6. Austin Simmons was the starting QB and he completed 14/28 passes for 147 passing yards, 1 touchdown, and 1 interception. Jamal Roberts led the team in rushing yards with 222 and 2 TDs. Cayden Lee led the receivers with 94 receiving yards on 7 receptions and 1 TD. Nicholas Rodriguez led the defense in that game with 12 tackles while Donta Simpson led the defense in sacks with 2. Elijah Dotson and Trajen Greco each came away with 1 interception for them in that one.

 

 

 

Ole Miss is entering this game with a 4-1 record overall and they have a 2-1 record in their conference games too. They are 2-0 in their home games, 1-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Vanderbilt 52-17. Trinidad Chambliss was the starting QB and he completed 20/30 passes for 213 passing yards, 3 touchdowns, and 1 interception. Makhi Frazier led the team in rushing yards with 73. Deuce Alexander led the receivers with 74 receiving yards on 5 receptions and 1 TD. Luke Ferrelli and Sharif Denson each led the defense in that game with 7 tackles while Blake Purchase led the defense in sacks with 2. Antonio Kite and Nick Cull each came away with 1 interception for them in that one.

The current betting odds have Ole Miss listed as a 6 point favorite in this game according to Draftkings Sportsbook. Ole Miss has looked great in their games this season with their 4-1 record overall and their 2-1 conference record which has them in the top half of the SEC. They have looked great on their home field too with their 2-0 home record this season. Meanwhile, Missouri has looked good in their games this season with their 5-1 record overall and their 2-1 conference record which has them in the top half of the SEC. They haven't been a great road team though with their 1-1 road record this year. Missouri is coming off a 27-6 win over Texas A&M in their last one and that was right after they pulled off a big upset win over Florida the week before. They have looked really good in their games, but a lot of their big wins also come at home. Their only loss this year was in one of their road games and they lost to Mississippi State who doesn't have a great program. Ole Miss is coming off a 52-17 win over Vanderbilt in their last one and they have looked like one of the best teams in the nation this year, led by one of the best QB's. Their only loss was on the road against Florida and they got destroyed in that one, but that was also a really tough situation for them, going on the road the next week after winning a huge emotional game over Lane Kiffin and LSU. Ole Miss has bounced back since that loss to Florida though and they still have one of the best offenses in the nation. Missouri has had a good defense this season, but that defense has looked a lot worse on the road and hasn't looked nearly as good against better offenses. The best way to place a bet here is on Ole Miss to cover the spread in this game. 

Missouri Mississippi Prediction:  Our NCAAF Pick for Saturday, October 17, 2026 (3:30 pm ET start time) is Ole Miss 42 Missouri 34.

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Missouri Tigers: 1-5 ATS as a road underdog. 3-6 ATS after a 2 game home stand. 2-6 ATS when playing against a top-level team (Win Pct. > 75%). 7-3 UNDER off a win against a conference rival. 7-3 UNDER after a win by 17 or more points.

Mississippi Rebels: 7-3 ATS in a home game where the total is between 56.5 and 63. 9-5 ATS after scoring 37 points or more last game. 8-4 ATS when playing against a top-level team (Win Pct. > 75%). 13-5 UNDER in home lined games. 7-3 UNDER in a home game where the total is between 56.5 and 63.

Missouri Tigers:  D. Smith (DL) Questionable - Undisclosed. G. Hoffman (TE) Out - Undisclosed. J. Brady (WR) Out - Undisclosed. C. Green (OG) Out - Undisclosed. A. Hardy (RB) Out - Leg.

Mississippi Rebels:  I. Hartrup (WR) Questionable - Undisclosed.

“You’ve got to see it as a boxing match, and you’ve got to see the body shots wear people down. When you have an identity, you just keep playing to your identity and figuring it out. You really trust your scheme and who you are when the game’s on the line. That’s what we do.” - Eli Drinkwitz after his team’s win against Texas A&M in their last game. 

“It's hard to go on the road in the SEC and win, especially you know in this environment with the weather.” - Pete Golding after his team’s win against Vandy in their last game. 

WR Montgomery, Naeshaun

WR Olugbode, Donovan

WR Lee, Cayden

TE Norfleet, Brett

QB Simmons, Austin

RB Roberts, Jamal

WR Alexander, Deuce

WR Fields, Horatio

WR Cook II, Johntay

TE Hasz, Luke

QB Chambliss, Trinidad

RB Lacy, Kewan

Passing: Austin Simmons (1,434)

Rushing: Jamal Roberts (828)

Receiving: Cayden Lee (616)

Touchdowns: Jamal Roberts (8)

Passing: Trinidad Chambliss (1,435)

Rushing: Kewan Lacy (230)

Receiving: Deuce Alexander (503)

Touchdowns: Kewan Lacy (5)

Coaches:

Missouri Tigers: Eli Drinkwitz (7th season)

Mississippi Rebels: Pete Golding (1st season)