Mississippi Rebels vs Mississippi State Bulldogs Prediction, Picks and Game Preview - 11/28/2025

Game Time: 12:00 pm ET, Friday, November 28, 2025

Venue:  Davis Wade Stadium, Mississippi State, MS

Where to Watch:  ABC

DraftKings:  Point Spread:  Ole Miss -7.5, MS State +7.5; Over/Under:  63.5 points

Bet365:  Point Spread:  Ole Miss -7, MS State +7; Over/Under:  63.5 points

BetMGM:  Point Spread:  Ole Miss -7, MS State +7; Over/Under:  63.5 points

Mississippi Rebels:  10-1 (6-1) (3rd place, SEC)

Mississippi State Bulldogs:  5-6 (1-6) (13th place, SEC)

Do not miss out on our expert handicapper analysis! Kyle Hunter is on a HOT STREAK in college football on a 5-0 CFB RUN for +$5,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Mississippi Rebels:  won their last game at home against the Florida Gators 34-24.

Mississippi State Bulldogs:  lost their last game on the road against the Missouri Tigers 49-27.

Ole Miss is entering this game with a 10-1 record overall and they have a 6-1 record in their conference games too. They are 8-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Florida 34-24. Trinidad Chambliss was the starting QB and he completed 26/35 passes for 301 passing yards, 1 touchdown, and 1 interception. Kewan Lacy led the team in rushing yards with 224 and 3 TDs. De'Zhaun Stribling led the receivers with 76 receiving yards on 4 receptions and 1 TD. TJ Dottery led the defense in that game with 6 solo tackles and 0 assisted tackles while Princewill Umanmielen led the defense in sacks with 1. Wydett Williams Jr. came away with the only interception for them in that one.

 

 

 

Mississippi State is entering this game with a 5-6 record overall and they have a 1-6 record in their conference games too. They are 3-3 in their home games, 2-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Missouri 49-27. Blake Shapen was the starting QB and he completed 19/33 passes for 199 passing yards, 0 touchdowns, and 2 interceptions. Davon Booth led the team in rushing yards with 34. Anthony Evans III led the receivers with 71 receiving yards on 7 receptions. Nic Mitchell led the defense in that game with 4 solo tackles and 3 assisted tackles while Nic Mitchell and Kalvin Dinkins each led the defense in sacks with 1. Nic Mitchell came away with the only interception for them in that one.

The current betting odds have Ole Miss listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. Ole Miss has looked great in their games this season with their 10-1 record overall and their 6-1 conference record which has them right near the top of the SEC. They are currently ranked inside the top 25 teams in the nation and they are right in the thick of things for a spot in the CFP. Meanwhile, Mississippi State hasn't looked good in their games this season with their 5-6 record overall and their 1-6 conference record which has them right near the bottom of the SEC. They looked a lot better in their non-conference games, but they haven't looked as good in their conference schedule. They are off a 49-27 loss to Mizzou in their last one and they were putting up a good fight early on in the SEC schedule, but lately they have looked a lot worse as they have been getting blown out in games. This is still a really big game for them that they are going to bring their best effort for with a bowl game on the line, but Ole Miss has been rolling all year and Mississippi State just doesn't have the same talent. Ole Miss also needs this game just as badly for the playoffs so look for them to finish the season strong against their rival who has been flailing lately. The best way to place a bet here is on Ole Miss to cover the spread in this game. 

Mississippi Mississippi State Prediction:  Our NCAAF Pick for Friday, November 28, 2025 (12:00 pm ET start time) is Ole Miss 42 MS State 20.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Mississippi Rebels Mississippi State Bulldogs prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Mississippi Rebels: 13-21 ATS as a road favorite of 7 points or less. 9-17 ATS on the road after 3 or more consecutive straight up wins. 11-21 ATS on the road when playing against a team with a losing record. 20-10 UNDER as a favorite. 5-1 UNDER when the total is greater than or equal to 63. 

Mississippi State Bulldogs: 9-5 ATS after 2 or more consecutive straight up losses. 7-4 ATS vs. good offensive  teams - scoring 31 or more points/game. 25-16 UNDER as a home underdog of 7 points or less. 6-2 UNDER in a home game where the total is between 63.5 and 70. 

Mississippi Rebels:  J. Rush (DL) Questionable - Undisclosed. R. Collins (LB) Questionable - Undisclosed.

Mississippi State Bulldogs:  W. Whitson (DL) Questionable - Undisclosed. B. Steen (OG) Questionable - Undisclosed. I. Smith (S) Questionable - Undisclosed. B. Smith (OG) Questionable - Undisclosed. J. Jefferson (CB) Questionable - Undisclosed.

“We’re 8-0 at home. It’s really cool. We shut them out in the second half and we came away with a 10-point conference game. Really pleased.” - Lane Kiffin after his team’s win against Florida in their last game. 

“I think our guys understand we've got a ton to play for. We've got a ton out in front of us. We have the opportunity to hit two huge goals for us as a program in year two, again, is exciting for us. And our guys understand, man, what's at stake, and it is, it's about us. It's about us maximizing every day from a preparation standpoint to give ourselves a chance to be able to go 1-0 on Friday morning in a huge game with a great atmosphere and a lot at stake.” - Jeff Lebby on the Egg Bowl this week.

WR Stribling, De'Zhaun

WR Wallace III, Harrison

WR Lee, Cayden

TE Wright, Dae'Quan

QB Chambliss, Trinidad

RB Lacy, Kewan

WR Thompson, Brenen

WR Mosley, Jordan

WR Evans III, Anthony

TE Traore, Seydou

QB Shapen, Blake

RB Bothwell, Fluff

Passing: Trinidad Chambliss (2,657)

Rushing: Kewan Lacy (1,136)

Receiving: Harrison Wallace III (647)

Touchdowns: Kewan Lacy (19)

Passing: Blake Shapen (2,433)

Rushing: Fluff Bothwell (559)

Receiving: Brenen Thompson (868)

Touchdowns: Davon Booth (9)

Coaches:

Mississippi Rebels: Lane Kiffin (6th season)

Mississippi State Bulldogs: Jeff Lebby (2nd season)