Minnesota Twins vs Houston Astros Prediction, Preview and Odds - 06/30/2026

Game Time: 8:10 pm ET, Tuesday, June 30, 2026

Venue:  Daikin Park, Houston, TX 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Twins -118, Astros -102; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Twins -115, Astros -105; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Twins -115, Astros -105; Over/Under:  8.5 runs

Minnesota Twins:  40-45 (3rd place, AL Central)

Houston Astros:  42-44 (3rd place, AL West)

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Minnesota Twins:  5-5 last 10

Houston Astros:  7-3 last 10

The Twins are entering this series off a win and won their 3-game series against the Colorado Rockies 2-1 in their last series. They enter this game with a 40-45 record overall and have a road record of 18-22. This is the 2nd game of a 3-game series with the Astros on Tuesday with the series opener still to be played on Monday. Their offense ranks 9th in the MLB with a .734 OPS. Zebby Matthews is their starting pitcher on Monday while Joe Ryan is making his start in this game on Tuesday. He is 5-4 with a 3.18 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 1 HR, and 1 BB with 9 SO on 8 hits through 6 IP against the Los Angeles Dodgers.

The Astros are entering this series off a win and won their 4-game series against the Detroit Tigers 3-1 in their last series. They enter this game with a 42-44 record overall and have a home record of 20-21. This is the 2nd game of a 3-game series with the Twins on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 12th in the MLB with a .726 OPS. Peter Lambert is their starting pitcher on Monday while Mike Burrows is making his start in this game on Tuesday. He is 3-8 with a 5.48 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 walk with 3 strikeouts on 2 hits through 6 innings pitched against the Toronto Blue Jays.

The current betting odds have the Twins listed as a slight favorite in this game according to Draftkings Sportsbook. The Twins haven't looked good in their games this season with their 40-45 record overall which has them right in the middle of the AL Central. They haven't been a great road team either with their 18-22 road record this year. Meanwhile, the Astros haven't looked great in their games this season with their 42-44 record overall which has them right in the middle of the AL West. They haven't looked great in their own ballpark either with their 20-21 home record this season. The Astros have been rolling lately as they are 7-3 in their last 10 games while the Twins are only 5-5 in their last 10 games, but the Twins are going to have the better pitching matchup here and they can take advantage of that. The Twins are going with Ryan in this one and he has looked good this season. He is 5-4 with a 3.18 ERA and he has been one of their best starters all year. He did give up 4 earned runs in his last start, but that hasn't been a common theme for him. He will be looking to bounce back with a better start and his team has been having success with him lately, winning 2 of their last 3 games with him starting. The Astros are going with Burrows in this one and he hasn't looked good this season. He is 3-8 with a 5.48 ERA and he has been giving up a ton of runs all year. He only gave up 1 earned run in his last start and even his team has won 3 games in a row now with him starting, but that hasn't been a common theme for him this year and the Twins don't have a bad offense either. Burrows isn't going to keep up his success lately, so look for the Twins to take this game with one of their more reliable starters going. The best way to place a bet here is on the Twins to win this game. 

Twins Astros Prediction:  Our MLB Pick for Tuesday, June 30, 2026 (8:10 pm ET start time) is Twins 5 Astros 2.

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Minnesota Twins: 192-217 (-48.5 units) on the moneyline in all games. 89-113 (-21.2 units) on the moneyline in road games. 117-102 (-25.2 units) on the moneyline as a favorite of -110 or higher. 27-12 OVER in road games.

Houston Astros: 77-70 (+25.6 units) on the moneyline as an underdog of +100 or higher. 158-132 (+12.6 units) on the moneyline vs. good fielding teams - averaging 0.6 errors/game or less. 162-142 (+3 units) on the moneyline against right-handed starters. 24-16 OVER in home games.

Minnesota Twins:  B. Ober (SP) Fifteen Day IL - Elbow. R. Jeffers (C) Ten Day IL - Hand. G. Acton (RP) Sixty Day IL - Shoulder. C. Sands (RP) Fifteen Day IL - Forearm. M. Abel (SP) Fifteen Day IL - Elbow. D. Festa (SP) Sixty Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Elbow.

Houston Astros:  L. Wade Jr. (1B) Ten Day IL - Hamstring. N. Allen (SS) Ten Day IL - Hamstring. B. Shewmake (SS) Ten Day IL - Groin. C. Correa (SS) Sixty Day IL - Ankle. L. McCullers Jr. (SP) Fifteen Day IL - Shoulder. B. Sousa (RP) Fifteen Day IL - Elbow. C. Javier (SP) Sixty Day IL - Shoulder. H. Wesneski (RP) Sixty Day IL - Elbow. R. Blanco (SP) Sixty Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow.

“I would say the biggest thing is consistency of approach. And I think [it helps a little bit that] he and Keith had a relationship before, because of being in Detroit together.” - Derek Shelton on Ryan Kreidler after his team’s win against the Rockies in their game on Sunday. 

“We came out on a mission trying to get to .500, trying to win series’, and that’s another series win. We’re really grinding through this. I’m really proud of the way we’re going about our business.” - Joe Espada after his team’s win against the Tigers in their game on Sunday. 

Trevor Larnach (L) LF

Byron Buxton (R) DH

Kody Clemens (L) 2B

Royce Lewis (R) 1B

Brooks Lee (S) 3B

Luke Keaschall (R) RF

Ryan Kreidler (R) SS

Austin Martin (R) CF

Alex Jackson (R) C

Jeremy Peña (R) SS

Yordan Alvarez (L) DH

Isaac Paredes (R) 3B

Christian Walker (R) 1B

Joey Loperfido (L) RF

Yainer Diaz (R) C

Taylor Trammell (L) LF

Jake Meyers (R) CF

Raynel Delgado (L) 2B

Batting Average:  Gabriel Gonzalez (.500)

Hits:  Byron Buxton (81)

Home Runs:  Byron Buxton (25)

RBI:  Josh Bell (51)

Stolen Bases:  Luke Keaschall (11)

Wins:  Bailey Ober (6)

Saves:  Yoendrys Gómez (7)

ERA:  Yoendrys Gómez (1.25)

Batting Average:  LaMonte Wade (.333)

Hits:  Yordan Alvarez (94)

Home Runs:  Yordan Alvarez (25)

RBI:  Yordan Alvarez (56)

Stolen Bases:  Cam Smith (9)

Wins:  Spencer Arrighetti (7)

Saves:  Josh Hader (7)

ERA:  Alimber Santa (0.71)

Managers:

Minnesota Twins: Derek Shelton (1st season)

Houston Astros: Joe Espada (3rd season)