Minnesota Twins vs Houston Astros Prediction, Preview and Odds - 06/14/2025

Game Time: 4:10 pm ET, Saturday, June 14, 2025

Venue:  Daikin Park, Houston, TX 

Where to Watch:  SCHN

DraftKings:  Moneyline odds:  Twins +104, Astros -127; Over/Under:  7 runs

Bet365:  Moneyline odds:  Twins +105, Astros -125; Over/Under:  7 runs

BetMGM:  Moneyline odds:  Twins +105, Astros -125; Over/Under:  7 runs

Minnesota Twins:  36-32 (2nd place, AL Central)

Houston Astros:  38-30 (1st place, AL West)

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Minnesota Twins:  5-5 last 10

Houston Astros:  7-3 last 10

The Twins are entering this series off a loss and lost their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 36-32 record overall and have a road record of 16-20. This is the 2nd game of a 3-game series with the Astros on Saturday with the series opener still to be played on Friday. Their offense ranks 15th in the MLB with a .706 OPS. Chris Paddack is their starting pitcher on Friday while Joe Ryan is making his start in this game on Saturday. He is 7-2 with a 2.96 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 ER, 0 HR, and 3 BB with 6 SO on 4 hits through 5 IP against the Toronto Blue Jays.

The Astros are entering this series off a win and won their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 38-30 record overall and have a home record of 24-13. This is the 2nd game of a 3-game series with the Twins on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 14th in the MLB with a .711 OPS. Rookie pitcher Colton Gordon is their starting pitcher on Friday while Hunter Brown is making his start in this game on Saturday. He is 8-3 with a 1.82 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 5 walks with 9 strikeouts on 4 hits through 5.1 innings pitched against the Cleveland Guardians.

The current betting odds have the Astros listed as a slight favorite in this game according to Draftkings Sportsbook. The Twins have looked good in their games this season with their 36-31 record overall which has them right near the top of the AL Central. They haven't been a great road team though with their 16-20 road record this season. Meanwhile, the Astros have looked good in their games this season with their 38-30 record overall which has them right at the top of the AL West. They have looked a lot better in their own ballpark too with their 24-13 home record. Both of these teams are going to have solid starters on the mound here, but the Astros have looked a lot better at home this year while the Twins haven't been nearly as good on the road. The Twins are also 5-5 in their last 10 games while the Astros have been the hotter team lately, going 7-3 in their last 10 games now. Brown is on the mound for the Astros here and he has been one of their best starters this season. He is 8-3 with a 1.82 ERA and hasn't been giving up many runs at all in any of his starts. He only gave up 1 earned run in his last start too and the team has won 3 games in a row with him starting. Ryan is on the mound for the Twins in this one and he has also looked really good this year. He is 7-2 with a 2.96 ERA and hasn't been giving up many runs either. He only gave up 2 earned runs in his last start and the team has won 6 games in a row with him starting too. As good as he has been this season, he will struggle more on the road here and the Astros can take advantage of that as they have been the much hotter team lately. The Twins have also been bad in road games all season. The best way to place a bet here is on the Astros to win this game. 

Twins Astros Prediction:  Our MLB Pick for Saturday, June 14, 2025 (4:10 pm ET start time) is Astros 3 Twins 2.

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Minnesota Twins: 54-30 (+18.6 units) on the moneyline against AL West opponents. 113-80 (+9 units) on the moneyline vs. an AL team with a slugging percentage .410 or worse on the season. 100-63 (+12.8 units) on the moneyline vs. AL teams scoring 4.4 or less runs/game on the season. 60-36 UNDER as an underdog of +100 to +150.

Houston Astros: 47-40 (-11.1 units) on the moneyline against AL Central opponents. 222-180 (-11.4 units) on the moneyline in all games. 110-96 (-32.3 units) on the moneyline in home games. 15-8 UNDER when the total is 7 or less.

Minnesota Twins:  P. Lopez (SP) Sixty Day IL - Shoulder. Z. Matthews (SP) Fifteen Day IL - Shoulder. L. Keaschall (2B) Sixty Day IL - Forearm. M. Tonkin (RP) Sixty Day IL - Shoulder.

Houston Astros:  I. Paredes (3B) Day To Day - Hamstring. Z. Dezenzo (RF) Ten Day IL - Hand. R. Blanco (SP) Sixty Day IL - Elbow. C. McCormick (LF) Ten Day IL - Oblique. H. Wesneski (RP) Sixty Day IL - Elbow. Y. Alvarez (LF) Ten Day IL - Hand. S. Arrighetti (SP) Fifteen Day IL - Thumb. L. Garcia (SP) Sixty Day IL - Elbow. C. Javier (SP) Sixty Day IL - Elbow. P. Leon (RF) Ten Day IL - Knee. J. France (SP) Sixty Day IL - Shoulder. T. Trammell (LF) Ten Day IL - Calf.

“Part of his job, which he does well -- and part of Pete’s job -- is to simplify things. You don’t want to have too many thoughts or topics in your head. If he’s able to execute his pitches, he’s a great pitch-maker. So if he can get back to just being the great pitch-maker that he is, which he’s been his entire career -- both Major Leagues and Minor Leagues and probably before that -- he’s gonna be more than OK. Simplifying his plan for the week will probably be part of that.” - Rocco Baldelli after his team’s loss against the Rangers in their game on Thursday.

“I thought their approach was staying in the at-bats, hitting the ball the other way. They fouled a ton of pitches off. They’re tough, they’re pesky. They’re not going to go without a fight and we fought back and won the series.” - Joe Espada after his team’s win against the White Sox in their game on Thursday.

Byron Buxton (R) CF

Ryan Jeffers (R) C

Carlos Correa (R) SS

Ty France (R) 1B

Royce Lewis (R) DH

Willi Castro (S) RF

Brooks Lee (S) 2B

Jonah Bride (R) 3B

Harrison Bader (R) LF

Jeremy Peña (R) SS

Isaac Paredes (R) 3B

Jose Altuve (R) LF

Yainer Diaz (R) C

Christian Walker (R) 1B

Jake Meyers (R) CF

Victor Caratini (S) DH

Cam Smith (R) RF

Brendan Rodgers (R) 2B

Batting Average:  Luke Keaschall (.368)

Hits:  Ty France (67)

Home Runs:  Byron Buxton (11)

RBI:  Byron Buxton (41)

Stolen Bases:  Byron Buxton (11)

Wins:  Joe Ryan (7)

Saves:  Jhoan Duran (10)

ERA:  Danny Coulombe (0.00)

Batting Average:  Jeremy Peña (.324)

Hits:  Jeremy Peña (85)

Home Runs:  Isaac Paredes (15)

RBI:  Isaac Paredes (42)

Stolen Bases:  Jeremy Peña (14)

Wins:  Hunter Brown (8)

Saves:  Josh Hader (18)

ERA:  Bryan Abreu (1.50)

Managers:

Minnesota Twins: Rocco Baldelli (7th season)

Houston Astros: Joe Espada (2nd season)