Minnesota Timberwolves vs San Antonio Spurs Prediction, Preview and Odds - 05/06/2026

Game Time: 9:30 pm ET, Wednesday, May 6, 2026

Venue:  Frost Bank Center, San Antonio, TX 

Where to Watch:  ESPN

DraftKings:  Point Spread:  Timberwolves +9.5, Spurs -9.5; Over/Under:  215.5 points

Bet365:  Point Spread:  Timberwolves +9.5, Spurs -9.5; Over/Under:  215.5 points

BetMGM:  Point Spread:  Timberwolves +9.5, Spurs -9.5; Over/Under:  215.5 points

Minnesota Timberwolves:  49-33 (3rd place, Northwest Division)

San Antonio Spurs:  62-20 (1st place, Southwest Division)

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Minnesota Timberwolves:  7-3 last 10

San Antonio Spurs:  7-3 last 10

The Timberwolves are entering the playoffs with a 49-33 record overall this season and they were 23-18 in their road games where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Denver Nuggets and the San Antonio Spurs. Julius Randle led the team in points in that game with 21 while Anthony Edwards was next on the team with 18 points. Mike Conley led the team in assists in that game with 6 while Julius Randle and Rudy Gobert each led the team in rebounds with 10. They were 45.6% from the field, 38.5% from 3-point range, and 57.1% from the free throw line with their shots in that game. Their offense is averaging 118 PPG and their defense is allowing their opponents to average 114.6 PPG against them. The Timberwolves have an ATS record of 41-48 this season and their O/U record is 38-51.

The Spurs are entering the playoffs with a 62-20 record overall this season and they were 32-8 in their home games where they will be in this game. They are entering this game off a loss against the Minnesota Timberwolves. Dylan Harper led the team in points in that game with 18 while Julian Champagnie and Stephon Castle each were next on the team with 17 points. De'Aaron Fox led the team in assists in that game with 6 while Victor Wembanyama led the team in rebounds with 15. They were 44.8% from the field, 27.8% from 3-point range, and 77.8% from the free throw line with their shots in that game. Their offense is averaging 119.8 PPG and their defense is allowing their opponents to average 111.5 PPG against them. The Spurs have an ATS record of 50-37-2 this season and their O/U record is 38-51.

The current betting odds have the Spurs listed as a 9.5 point favorite in this game according to Draftkings Sportsbook. The Spurs have looked great in their games this season with their 62-20 record overall which had them right near the top of the West with one of the best records in the entire NBA. They have looked great on their home court too with their 32-8 home record this season. Meanwhile, the Timberwolves have looked good in their games this season with their 49-33 record overall which had them in the top half of the West. They have been a good road team too with their 23-18 road record this year. This is game 2 of a 7-game series between the 2 seeded Spurs and the 6 seeded Timberwolves in the West for the 2nd round of the NBA playoffs. The Timberwolves are entering this game with a 1-0 series lead after winning game 1 by a score of 104-102. The Timberwolves looked great in the 1st round as they only needed 6 games to dispose of the Nuggets and they even closed out the series without their best player. Edwards came back for the start of this series and the Timberwolves were able to get the job done on the road and flip the home advantage in their favor, now starting to roll again with 2 wins in a row, but the Spurs looked like one of the best teams in the NBA all season and they aren't going to go down without a fight. They did lose a home game in the 1st round against an inferior opponent, but they answered the call against the Trail Blazers after that and only lost that 1 game. They will be looking to bounce back after falling behind in this series now and even though the Timberwolves have looked great in the playoffs, they did lose 2 games in their 1st round series and both of those losses were by double digits, so they tend to lose big when they do lose. The Spurs are going to have an answer at home to that loss and the Timberwolves aren't going to have the same intensity in this 2nd game since they have already done their job, especially with Edwards not 100% either. Look for the Spurs to take advantage of that in this one and bounce back with a double digit win to even up this series. The best way to place a bet here is on the Spurs to cover the spread in this game. 

Timberwolves Spurs Prediction:  Our NBA Pick for Wednesday, May 6, 2026 (9:30 pm ET start time) is Spurs 117 Timberwolves 106.

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Minnesota Timberwolves: 7-4 ATS when playing against a top-level team (Win Pct. > 70%). 25-17 ATS versus good 3 point shooting teams - making 36% of their attempts or more. 19-11 ATS versus good teams - outscoring their opponents by 3+ points/game. 8-3 UNDER off an upset win as an underdog. 19-10 UNDER versus good teams - outscoring their opponents by 3+ points/game.

San Antonio Spurs: 2-6 ATS at home revenging a same season loss vs opponent. 4-8 ATS at home against Northwest division opponents. 25-15 UNDER as a home favorite. 9-2 UNDER after a loss by 6 points or less. 27-19 UNDER versus good offensive teams - scoring 116+ points/game. 

Minnesota Timberwolves:  A. Dosunmu (SG) Day To Day - Calf. D. DiVincenzo (SG) Out For Season - Leg.

San Antonio Spurs:  C. Bryant (PF) Day To Day - Foot. D. Jones Garcia (SF) Out For Season - Ankle.

“I know for a fact, just me being out there, it calms everybody down. Not saying there’s any pressure on any of my teammates, but it takes pressure off of everybody just knowing that I’m out there, I’m available to play, yeah. And just doing what I do best, just trying to put the ball in the hoop.” - Anthony Edwards after their win against the Spurs in the 1st game of this series on Monday. 

“We have to be better. It shows up on the stat sheet. We need to figure out before 48 hours what we can do better and I’ve got no doubt that we will. I trust us.” - Victor Wembanyama after their loss against the Timberwolves in game 1 of this series on Monday. 

PG Mike Conley

SG Anthony Edwards

SF Jaden McDaniels

PF Julius Randle

C Rudy Gobert

PG De'Aaron Fox

SG Stephon Castle

SF Devin Vassell

PF Julian Champagnie

C Victor Wembanyama

PPG: Anthony Edwards (28.8)

APG: Julius Randle (5)

Reb/G: Rudy Gobert (11.5)

PPG: Victor Wembanyama (25)

APG: Stephon Castle (7.4)

Reb/G: Victor Wembanyama (11.5)

Coaches:

Minnesota Timberwolves: Chris Finch (6th season)

San Antonio Spurs: Mitch Johnson (2nd season)