Milwaukee Bucks vs Detroit Pistons Prediction, Preview and Odds - 12/06/2025

Game Time: 7:30 pm ET, Saturday, December 6, 2025

Venue:  Little Caesars Arena, Detroit, MI

Where to Watch:  FDSWI, FDSDT

DraftKings:  Point Spread:  Bucks +12.5, Pistons -12.5; Over/Under:  224.5 points

Bet365:  Point Spread:  Bucks +12.5, Pistons -12.5; Over/Under:  224.5 points

BetMGM:  Point Spread:  Bucks +12.5, Pistons -12.5; Over/Under:  224.5 points

Milwaukee Bucks:  10-13 (3rd place, Central Division)

Detroit Pistons:  17-5 (1st place, Central Division)

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Milwaukee Bucks:  2-8 last 10

Detroit Pistons:  7-3 last 10

The Bucks are entering this game with a 10-13 record overall this season and they are 3-7 in their road games this season where they will be in this game. They are entering this game off a win against the Detroit Pistons, but this is also the 2nd game of a back-to-back for them with their game against the Philadelphia 76ers still to be played on Friday night. In their game against the Pistons, Kevin Porter Jr. led the team in points in that game with 26 while Ryan Rollins was next on the team with 22 points. Ryan Rollins led the team in assists in that game with 8 while Jericho Sims led the team in rebounds with 14. They were 48.8% from the field, 29.5% from 3-point range, and 95.2% from the free throw line with their shots in that game. Their offense is averaging 115.8 PPG and their defense is allowing their opponents to average 117.8 PPG against them. The Bucks have an ATS record of 10-13 this season and their O/U record is 11-12.

The Pistons are entering this game with a 17-5 record overall this season and they are 8-2 in their home games this season where they will be in this game. They are entering this game off a loss against the Milwaukee Bucks, but this is also the 2nd game of a back-to-back for them with their game against the Portland Trail Blazers still to be played on Friday night. In their game against the Bucks, Tobias Harris led the team in points in that game with 20 while Cade Cunningham was next on the team with 17 points. Cade Cunningham led the team in assists in that game with 7 while Cade Cunningham led the team in rebounds with 7. They were 40% from the field, 32.6% from 3-point range, and 79.2% from the free throw line with their shots in that game. Their offense is averaging 118.3 PPG and their defense is allowing their opponents to average 113.2 PPG against them. The Pistons have an ATS record of 13-9 this season and their O/U record is 11-10-1.

The current betting odds have the Pistons listed as a 12.5 point favorite in this game according to Draftkings Sportsbook. The Pistons have looked great in their games this season with their 17-5 record overall which has them right at the top of the East with one of the best records in the entire NBA. They have also looked great on their home court this year with their 8-2 home record. Meanwhile, the Bucks haven't looked good in their games this season with their 10-13 record overall which has them in the bottom half of the East. They have been a terrible road team too with their 3-7 road record this year. They haven't looked that good lately either, going 2-8 in their last 10 games, and they are dealing with some injuries now. They are off a win over the Pistons in their last one, but they did lose Giannis to an injury in that game and will be without him for the time being. This isn't a great situation for them to be in either since they are on the road on a back-to-back here. The Pistons have been rolling all season with one of the best records in the NBA and they are also 7-3 in their last 10 games too. They are also on a back-to-back here with a game against the 76ers, but they are getting a Trail Blazers team that hasn't been great this season, and this will be the game the Pistons are focused on since they did lose to the Bucks the other night. Look for the Pistons to get their revenge at home and take advantage of a Bucks team that is missing their best player. The best way to place a bet here is on the Pistons to cover the spread in this game. 

Bucks Pistons Prediction:  Our NBA Pick for Saturday, December 6, 2025 (7:30 pm ET start time) is Pistons 118 Bucks 92.

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Milwaukee Bucks: 3-6 ATS versus good foul drawing teams - attempting 27 free throws/game or more. 13-20 ATS versus teams who average 9 or more steals/game on the season. 16-29 ATS when playing only their 2nd game in 5 days. 29-16 OVER when playing only their 2nd game in 5 days.

Detroit Pistons: 13-5 ATS revenging a straight up loss vs opponent as a favorite. 22-9 ATS when playing against a marginal losing team (Win Pct. 40% to 49%). 13-5 OVER revenging a straight up loss vs opponent as a favorite. 20-11 OVER when playing against a marginal losing team (Win Pct. 40% to 49%).

Milwaukee Bucks:  G. Antetokounmpo (PF) Out - Calf. T. Prince (SF) Out - Neck.

Detroit Pistons:  D. Robinson (SF) Day To Day - Ankle. B. Klintman (SF) Out - Ankle. M. Sasser (PG) Day To Day - Hip.

“Giannis has never asked to be traded. Ever. I can’t make that more clear.” - Doc Rivers on Giannis asking for a trade.

"It was impactful because we allowed it to be, and then, it started to impact our defense. It slowed us down. We got stagnant against the zone. We could have moved it a little bit better." - J.B. Bickerstaff on the Bucks’ zone defense in their last meeting.

PG Ryan Rollins

SG Gary Trent Jr.

SF AJ Green

PF Bobby Portis

C Myles Turner

PG Cade Cunningham

SG Duncan Robinson

SF Ausar Thompson

PF Tobias Harris

C Jalen Duren 

PPG: Giannis Antetokounmpo (28.9)

APG: Giannis Antetokounmpo (6.1)

Reb/G: Giannis Antetokounmpo (10.1)

PPG: Cade Cunningham (27.6)

APG: Cade Cunningham (9.2)

Reb/G: Jalen Duren (11.5)

Coaches:

Milwaukee Bucks: Doc Rivers (3rd season)

Detroit Pistons: J.B. Bickerstaff (2nd season)