Milwaukee Brewers vs San Diego Padres Prediction, Preview and Odds - 08/12/2026

Game Time: 4:10 pm ET, Wednesday, August 12, 2026

Venue:  Petco Park, San Diego, CA

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Brewers -126, Padres +104; Over/Under:  8 runs

Bet365:  Moneyline odds:  Brewers -125, Padres +105; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Brewers -125, Padres +105; Over/Under:  8 runs

Milwaukee Brewers:  74-45 (1st place, NL Central)

San Diego Padres:  63-57 (3rd place, NL West)

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Milwaukee Brewers:  6-4 last 10

San Diego Padres:  7-3 last 10

The Brewers are entering this series off a win and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 74-45 record overall and have a road record of 33-23. This is the series finale of a 3-game series with the Padres on Wednesday with the 2nd game still to be played on Tuesday. The Brewers lost the series opener on Monday. Their offense ranks 6th in the MLB with a .734 OPS. Kyle Harrison is their starting pitcher on Tuesday while Dustin May is making his start in this game on Wednesday. He is 6-7 with a 4.30 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 3 BB with 5 SO on 3 hits through 6 IP against the Pittsburgh Pirates.

The Padres are entering this series off a win and won their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 63-57 record overall and have a home record of 35-26. This is the 3rd game of a 3-game series with the Brewers on Wednesday with the 2nd game of this series still to be played on Tuesday. The Padres won the 1st game of this series on Monday. Their offense ranks 24th in the MLB with a .698 OPS. Walker Buehler is their starting pitcher on Tuesday while Robbie Ray is making his start in this game on Wednesday. He is 10-7 with a 3.24 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 1 homer, and 5 walks with 2 strikeouts on 7 hits through 5 innings pitched against the Houston Astros.

The current betting odds have the Padres listed as a slight underdog in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 74-45 record overall which has them right at the top of the NL Central with one of the best records in MLB. They have been a great road team too with their 33-23 road record this year. Meanwhile, the Padres have looked good in their games this season with their 63-57 record overall which has them right in the middle of the NL West. They have looked good in their own ballpark too with their 35-26 home record this season. The Brewers are 6-4 in their last 10 games and they have been one of the best teams in the league this year, but they are not the hotter team here. The Padres have been rolling lately, now 7-3 in their last 10 games, and their offense has looked a lot better over the last week too. The Padres are going with Ray in this one and he has looked good this season. He is 10-7 with a 3.24 ERA and he was having a great year even when he was pitching for the terrible Giants. He did give up 4 earned runs in his last start, but that hasn't been a common theme for him this year and his team has been having a lot of success with him, winning 2 of their last 3 games with him starting. The Brewers are going with May in this one and he hasn't looked great this season. He is 6-7 with a 4.30 ERA and he was having a lot of trouble with the Cardinals. His team has had more success with him lately, winning 2 games in a row now with him starting, and he only gave up 2 earned runs in his last start too, but that hasn't been a common theme for him this season and he has been giving up quite a few runs all year. The Brewers do have the better offense this season, but the Padres have been much hotter lately and can take advantage of this better pitching matchup. The best way to place a bet here is on the Padres to win this game. 

Brewers Padres Prediction:  Our MLB Pick for Wednesday, August 12, 2026 (4:10 pm ET start time) is Padres 4 Brewers 3.

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Milwaukee Brewers: 74-45 (+13.2 units) on the moneyline in all games. 33-23 (+5.8 units) on the moneyline in road games. 59-30 (+12.3 units) on the moneyline as a favorite of -110 or higher. 21-11 UNDER as a road favorite of -110 or higher.

San Diego Padres: 23-28 (-7.5 units) on the moneyline when the total is 8 to 8.5. 25-31 (-4.7 units) on the moneyline when playing against a team with a winning record. 23-25 (-3.3 units) on the moneyline vs. an NL team with a slugging percentage of .400 or worse on the season. 36-26 UNDER when the money line is +125 to -125.

Milwaukee Brewers:  J. Ortiz (SS) Day To Day - Neck. S. Frelick (RF) Ten Day IL - Shoulder. J. Romero (RP) Fifteen Day IL - Appendix. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. J. Kuhnel (RP) Fifteen Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

San Diego Padres:  M. Andujar (DH) Ten Day IL - Wrist. S. Taylor (LF) Ten Day IL - Oblique. J. Adam (RP) Sixty Day IL - Shoulder. D. Morgan (RP) Fifteen Day IL - Knee. L. Giolito (SP) Fifteen Day IL - Elbow. R. Laureano (LF) Sixty Day IL - Hip. N. Pivetta (SP) Sixty Day IL - Elbow. B. Hoeing (RP) Sixty Day IL - Elbow. J. Musgrove (SP) Sixty Day IL - Elbow.

"We made it a point that Merrill wasn't going to beat us. But sometimes you can't control where the ball is going to go." - Pat Murphy after his team’s loss against the Padres in their game on Monday. 

“These games are all going to be close. We got the big home run at the end to take the lead and we were able to get to our bullpen, which is the strength of our team. But it’s going to be a tightly contested series. I would expect two more games just like tonight.” - Craig Stammen after his team’s win against the Brewers in their game on Monday.

Brice Turang (L) 2B

Jackson Chourio (R) LF

Jake Bauers (L) 1B

Andrew Vaughn (R) 3B

Garrett Mitchell (L) CF

William Contreras (R) C

Christian Yelich (L) DH

Luis Lara (S) RF

David Hamilton (L) SS

Fernando Tatis Jr. (R) RF

Jake Cronenworth (L) 2B

Manny Machado (R) 3B

Ty France (R) 1B

Jackson Merrill (L) CF

Luis Rengifo (S) LF

Gavin Sheets (L) DH

Freddy Fermin (R) C

Sung-Mun Song (L) SS

Batting Average:  Jihwan Bae (1.000)

Hits:  Brice Turang (119)

Home Runs:  Jake Bauers (21)

RBI:  Brice Turang (74)

Stolen Bases:  David Hamilton (21)

Wins:  Aaron Ashby (13)

Saves:  Trevor Megill (21)

ERA:  Easton McGee (0.00)

Batting Average:  Austin Hays (1.000)

Hits:  Fernando Tatis (130)

Home Runs:  Manny Machado (23)

RBI:  Manny Machado (70)

Stolen Bases:  Fernando Tatis (26)

Wins:  Adrian Morejon (8)

Saves:  Mason Miller (30)

ERA:  Mason Miller (0.89)

Managers:

Milwaukee Brewers: Pat Murphy (3rd season)

San Diego Padres: Craig Stammen (1st season)