Milwaukee Brewers vs Cincinnati Reds Prediction, Preview and Odds - 06/24/2026

Game Time: 7:10 pm ET, Wednesday, June 24, 2026

Venue:  Great American Ball Park, Cincinnati, OH

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Brewers -143, Reds +119; Over/Under:  9 runs

Bet365:  Moneyline odds:  Brewers -140, Reds +120; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Brewers -145, Reds +120; Over/Under:  9 runs

Milwaukee Brewers:  47-29 (1st place, NL Central)

Cincinnati Reds:  37-40 (5th place, NL Central)

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Milwaukee Brewers:  6-4 last 10

Cincinnati Reds:  5-5 last 10

The Brewers are entering this series off a win and lost their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 47-29 record overall and have a road record of 22-14. This is the series finale of a 3-game series with the Reds on Wednesday with the 2nd game still to be played on Tuesday. The Brewers won the series opener on Monday. Their offense ranks 11th in the MLB with a .728 OPS. Brandon Sproat is their starting pitcher on Tuesday while rookie pitcher Shane Drohan is making his start in this game on Wednesday. He is 3-2 with a 3.40 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 3 BB with 3 SO on 3 hits through 5 IP against the Cleveland Guardians.

The Reds are entering this series off a win and won their 3-game series against the New York Yankees 2-1 in their last series. They enter this game with a 37-40 record overall and have a home record of 19-20. This is the 3rd game of a 3-game series with the Brewers on Wednesday with the 2nd game of this series still to be played on Tuesday. The Reds lost the 1st game of this series on Monday. Their offense ranks 23rd in the MLB with a .700 OPS. Nick Lodolo is their starting pitcher on Tuesday while Rhett Lowder is making his start in this game on Wednesday. He is 3-4 with a 4.82 ERA this season. His team lost 5 of their last 6 games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 2 homers, and 3 walks with 5 strikeouts on 6 hits through 5.1 innings pitched against the New York Yankees.

The current betting odds have the Brewers listed as a favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 47-29 record overall which has them right at the top of the NL Central with one of the best records in MLB. They have been a good road team too with their 22-14 road record this year. Meanwhile, the Reds haven't looked great in their games this season with their 37-40 record overall which has them right at the bottom of the NL Central. They haven't looked great in their own ballpark either with their 19-20 home record this season. The Reds are 5-5 in their last 10 games, but they have been slipping over the last few weeks while the Brewers have been one of the best teams in MLB this season and are getting hot again, now 6-4 in their last 10 games. The Brewers are going with Drohan in this one and he has been good this season. He is 3-2 with a 3.40 ERA and has been having a good rookie year so far. His team has lost 2 games in a row now with him starting, but that hasn't been a common theme and he is coming off a great start in which he gave up 1 earned run. The Reds are going with Lowder in this one and he hasn't looked great this season. He is 3-4 with a 4.82 ERA and he has been dealing with some injuries this season too. He is coming off another bad start in which he gave up 4 earned runs, something that has been a common theme for him this year, and the team has also had a lot of trouble with him, losing 5 of their last 6 games with him starting. The Reds don't have a bad offense, but the Brewers do have the better offense which has been hot lately and they can take advantage of this pitching matchup. The best way to place a bet here is on the Brewers to win this game. 

Brewers Reds Prediction:  Our MLB Pick for Wednesday, June 24, 2026 (7:10 pm ET start time) is Brewers 5 Reds 2.

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Milwaukee Brewers: 241-172 (+47.4 units) on the moneyline in all games. 114-90 (+28.2 units) on the moneyline in road games. 146-89 (+19.6 units) on the moneyline as a favorite of -110 or higher. 3-1 OVER when the total is 9 to 9.5.

Cincinnati Reds: 196-206 (-6.7 units) on the moneyline in all games. 102-98 (-12.3 units) on the moneyline in home games. 74-97 (-8.9 units) on the moneyline as an underdog of +100 to +150. 20-8 OVER when the total is 9 to 9.5.

Milwaukee Brewers:  Q. Priester (SP) Sixty Day IL - Wrist. B. Sproat (SP) Day To Day - Hamstring. C. Crow (SP) Fifteen Day IL - Forearm. B. Fitzpatrick (RP) Sixty Day IL - Elbow. C. Rodriguez (RP) Fifteen Day IL - Shoulder. D. Hall (RP) Fifteen Day IL - Pectoral. R. Zastryzny (RP) Fifteen Day IL - Shoulder. A. Zerpa (RP) Sixty Day IL - Forearm. L. Henderson (SP) Fifteen Day IL - Back. B. Lockridge (LF) Ten Day IL - Knee. J. Koenig (RP) Fifteen Day IL - Elbow.

Cincinnati Reds:  E. De La Cruz (SS) Ten Day IL - Hamstring. G. Ashcraft (RP) Sixty Day IL - Forearm. K. Hayes (3B) Ten Day IL - Back. E. Pagan (RP) Fifteen Day IL - Hamstring. B. Williamson (SP) Sixty Day IL - Shoulder. H. Greene (SP) Sixty Day IL - Elbow.

“I was just really, really happy for him. Because of what he means to the club and how he goes about his business. Six innings, one base runner. It’s just a special outing. It’s pitching in its greatest form.” - Pat Murphy on Brandon Woodruff after his team’s win against the Reds in their game on Monday. 

"The breaking ball that got away, that changes the game a lot. I would say though, that I thought our guys pitched terrific. When they pitch like that, it's a lot easier to feel that the glass is half full." - Terry Francona after his team’s loss against the Brewers in their game on Monday.

Christian Yelich (L) DH

Jackson Chourio (R) LF

Brice Turang (L) 2B

William Contreras (R) C

Jake Bauers (L) 1B

Garrett Mitchell (L) CF

Sal Frelick (L) RF

Joey Ortiz (R) SS

David Hamilton (L) 3B

Blake Dunn (R) CF

JJ Bleday (L) LF

Sal Stewart (R) 1B

Nathaniel Lowe (L) DH

Spencer Steer (R) 2B

Eugenio Suárez (R) 3B

Noelvi Marte (R) RF

Tyler Stephenson (R) C

Matt McLain (R) SS

Batting Average:  Cooper Pratt (.350)

Hits:  William Contreras (83)

Home Runs:  Jake Bauers (13)

RBI:  Brice Turang (47)

Stolen Bases:  David Hamilton (16)

Wins:  Aaron Ashby (10)

Saves:  Trevor Megill (9)

ERA:  Jared Koenig (0.00)

Batting Average:  Blake Dunn (.280)

Hits:  Sal Stewart (72)

Home Runs:  Sal Stewart (14)

RBI:  Sal Stewart (54)

Stolen Bases:  Sal Stewart (11)

Wins:  Chase Burns (9)

Saves:  Emilio Pagán (6)

ERA:  Caleb Ferguson (1.50)

Managers:

Milwaukee Brewers: Pat Murphy (3rd season)

Cincinnati Reds: Terry Francona (2nd season)