Milwaukee Brewers vs Chicago Cubs Prediction, Preview and Odds - 09/03/2026

Game Time: 7:15 pm ET, Thursday, September 3, 2026

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  MLB TV, FOX

DraftKings:  Moneyline odds:  Brewers -115, Cubs -105; Over/Under:  8 runs

Bet365:  Moneyline odds:  Brewers -115, Cubs -105; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Brewers -115, Cubs -105; Over/Under:  8.5 runs

Milwaukee Brewers:  86-53 (1st place, NL Central)

Chicago Cubs:  78-61 (2nd place, NL Central)

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Milwaukee Brewers:  6-4 last 10

Chicago Cubs:  4-6 last 10

The Brewers are entering this series off a loss and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with an 86-53 record overall and have a road record of 39-28. This is the series finale of a 4-game series with the Cubs on Thursday with the 3rd game still to be played on Wednesday. The Brewers lost the series opener on Monday and won the 2nd game on Tuesday. Their offense ranks 4th in the MLB with a .738 OPS. Jacob Misiorowski is their starting pitcher on Wednesday while Logan Henderson is making his start in this game on Thursday. He is 9-2 with a 2.48 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 1 HR, and 0 BB with 7 SO on 1 hit through 7 IP against the Texas Rangers.

The Cubs are entering this series off a loss and lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 78-61 record overall and have a home record of 40-30. This is the 4th game of a 4-game series with the Brewers on Thursday with the 3rd game of this series still to be played on Wednesday. The Cubs won the 1st game of this series on Monday and lost the 2nd game on Tuesday. Their offense ranks 1st in the MLB with a .773 OPS. David Peterson is their starting pitcher on Wednesday while Kevin Gausman is making his start in this game on Thursday. He is 8-11 with a 4.52 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 5 earned runs, 2 homers, and 2 walks with 7 strikeouts on 6 hits through 5 innings pitched against the Cincinnati Reds.

The current betting odds have the Brewers listed as a slight favorite in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 86-53 record overall which has them right at the top of the NL Central with the best record in MLB. They have been a good road team too with their 39-28 road record this year. Meanwhile, the Cubs have looked really good in their games this season with their 78-61 record overall which has them right near the top of the NL Central. They have looked good in their own ballpark too with their 40-30 home record this season. The Cubs have one of the best offenses in MLB, but lately they haven't looked that great, now 4-6 in their last 10 games. The Brewers have been getting hot though, going 6-4 in their last 10 games, and they also have a really good offense to lean on along with the better pitching matchup here. The Brewers are going with Henderson in this one and he has looked great this season. He is 9-2 with a 2.48 ERA and the team has been having a ton of success with him. They have won 3 games in a row now with him starting and he is coming off another great start giving up 1 earned run which has been a common theme for him. The Cubs are going with Gausman in this one and he hasn't looked great this year. He is 8-11 with a 4.52 ERA and he has been giving up quite a few runs all year. His team has been having success with him lately, winning 3 games in a row with him starting, but he is coming off another bad start in which he gave up 5 earned runs and that has been a common theme for him. The Cubs haven't had a good bullpen this season either as they have had issues with their pitching staff all year, so look for the Brewers to take advantage of this pitching matchup in this pivotal series. The best way to place a bet here is on the Brewers to win this game. 

Brewers Cubs Prediction:  Our MLB Pick for Thursday, September 3, 2026 (7:15 pm ET start time) is Brewers 5 Cubs 2.

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Milwaukee Brewers: 280-196 (+53.5 units) on the moneyline in all games. 131-104 (+28.3 units) on the moneyline in road games. 180-107 (+25.7 units) on the moneyline as a favorite of -110 or higher. 21-13 UNDER against division opponents.

Chicago Cubs: 76-73 (-7.4 units) on the moneyline against division opponents. 37-45 (-8.9 units) on the moneyline when playing against a good team (Win Pct. 54% to 62%). 35-47 (-13.9 units) on the moneyline vs. a team with a good bullpen whose ERA is 3.45 or better. 22-15 UNDER as a home underdog of +100 or higher.

Milwaukee Brewers:  B. Wilson (RP) Fifteen Day IL - Back. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. J. Kuhnel (RP) Fifteen Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

Chicago Cubs:  P. Maton (RP) Sixty Day IL - Knee. E. Cabrera (SP) Fifteen Day IL - Blister. D. Swanson (SS) Ten Day IL - Side. B. Brown (RP) Sixty Day IL - Neck. G. Hollowell (RP) Fifteen Day IL - Shoulder. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

“I was asked the question last night if you think your guys can bounce back. I think they answered it for you.” - Pat Murphy after his team’s win against the Cubs in their game on Tuesday. 

“We’ve got to pitch better. There’s no question – we’ve got to pitch better. But, these are the guys, man. This is them, so we’ve got to help them get better and we’ve got to get outs.” - Craig Counsell after his team’s loss against the Brewers in their game on Tuesday.

Jackson Chourio (R) LF

Brice Turang (L) 2B

William Contreras (R) C

Jake Bauers (L) RF

Andrew Vaughn (R) 1B

Christian Yelich (L) DH

Luis Lara (S) CF

Joey Ortiz (R) 3B

Cooper Pratt (R) SS

Pete Crow-Armstrong (L) CF

Seiya Suzuki (R) RF

Alex Bregman (R) 3B

Tyrone Taylor (R) LF

Nico Hoerner (R) SS

Michael Busch (L) 1B

Carson Kelly (R) C

BJ Murray Jr. (S) DH

Matt Shaw (R) 2B

Batting Average:  Jihwan Bae (.500)

Hits:  William Contreras (134)

Home Runs:  Jake Bauers (23)

RBI:  Brice Turang (78)

Stolen Bases:  David Hamilton (24)

Wins:  Jacob Misiorowski (14)

Saves:  Trevor Megill (25)

ERA:  Easton McGee (0.00)

Batting Average:  Tyrone Taylor (.413)

Hits:  Pete Crow-Armstrong (150)

Home Runs:  Pete Crow-Armstrong (38)

RBI:  Pete Crow-Armstrong (91)

Stolen Bases:  Pete Crow-Armstrong (32)

Wins:  Colin Rea (8)

Saves:  Jacob Webb (9)

ERA:  Ty Blach (0.00)

Managers:

Milwaukee Brewers: Pat Murphy (3rd season)

Chicago Cubs: Craig Counsell (3rd season)