Milwaukee Brewers vs Chicago Cubs Prediction, Preview and Odds - 09/01/2026

Game Time: 7:40 pm ET, Tuesday, September 1, 2026

Venue:  Wrigley Field, Chicago, IL

Where to Watch:  MLB TV, TBS

DraftKings:  Moneyline odds:  Brewers +104, Cubs -126; Over/Under:  10 runs

Bet365:  Moneyline odds:  Brewers +105, Cubs -125; Over/Under:  10 runs

BetMGM:  Moneyline odds:  Brewers +105, Cubs -125; Over/Under:  10 runs

Milwaukee Brewers:  85-52 (1st place, NL Central)

Chicago Cubs:  77-60 (2nd place, NL Central)

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Milwaukee Brewers:  7-3 last 10

Chicago Cubs:  3-7 last 10

The Brewers are entering this series off a loss and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with an 85-52 record overall and have a road record of 38-27. This is the 2nd game of a 4-game series with the Cubs on Tuesday with the series opener still to be played on Monday. Their offense ranks 5th in the MLB with a .735 OPS. Kyle Harrison is their starting pitcher on Monday while Robert Gasser is making his start in this game on Tuesday. He is 4-5 with a 4.59 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 1 ER, 0 HR, and 2 BB with 6 SO on 6 hits through 5.1 IP against the New York Mets.

The Cubs are entering this series off a loss and lost their 3-game series against the Cincinnati Reds 2-1 in their last series. They enter this game with a 77-60 record overall and have a home record of 39-29. This is the 2nd game of a 4-game series with the Brewers on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 1st in the MLB with a .767 OPS. Clay Holmes is their starting pitcher on Monday while Matthew Boyd is making his start in this game on Tuesday. He is 8-3 with a 3.99 ERA this season. His team lost their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 2 walks with 5 strikeouts on 3 hits through 6 innings pitched against the Arizona Diamondbacks.

The current betting odds have the Brewers listed as a slight underdog in this game according to Draftkings Sportsbook. The Brewers have looked great in their games this season with their 85-52 record overall which has them right at the top of the NL Central with the best record in MLB. They have been a good road team too with their 38-27 road record this year. Meanwhile, the Cubs have looked really good in their games this season with their 77-60 record overall which has them right near the top of the NL Central. They have looked good in their own ballpark too with their 39-29 home record this season. The Cubs haven't looked that great lately though, now 3-7 in their last 10 games and their pitching has been an issue. The Brewers have been rolling though, now 7-3 in their last 10 games. The Brewers are going with Gasser in this one and he hasn't looked great this season. He is 4-5 with a 4.59 ERA, but lately he has looked a lot better. He is coming off a good start allowing 1 earned run which is starting to become a common theme for him and the team has been having success with him too, winning 2 games in a row now with him starting. The Cubs are going with Boyd in this one and he hasn't looked bad this season. He is 8-3 with a 3.99 ERA, but lately the team hasn't been having a lot of success with him. He only gave up 1 earned run in his last start, but that hasn't been a common theme for him all year and the team has lost 3 games in a row now with him starting. The Cubs do have the stronger offense to lean on here, but not by much and the Brewers have the much better bullpen. The best way to place a bet here is on the Brewers to win this game. 

Brewers Cubs Prediction:  Our MLB Pick for Tuesday, September 1, 2026 (7:40 pm ET start time) is Brewers 4 Cubs 2.

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Milwaukee Brewers: 279-195 (+53.4 units) on the moneyline in all games. 130-103 (+28.2 units) on the moneyline in road games. 80-72 (+25.4 units) on the moneyline as an underdog of +100 or higher. 21-11 UNDER against division opponents.

Chicago Cubs: 108-124 (-20.4 units) on the moneyline when the money line is +125 to -125. 75-72 (-7.2 units) on the moneyline against division opponents. 58-58 (-8 units) on the moneyline against left-handed starters. 45-30 UNDER vs. a team with a good bullpen whose ERA is 3.45 or better.

Milwaukee Brewers:  A. Uribe (RP) Fifteen Day IL - Forearm. J. Romero (RP) Fifteen Day IL - Appendix. R. Zastryzny (RP) Sixty Day IL - Shoulder. B. Woodruff (SP) Sixty Day IL - Shoulder. J. Kuhnel (RP) Fifteen Day IL - Shoulder. Q. Priester (SP) Sixty Day IL - Wrist. B. Fitzpatrick (RP) Sixty Day IL - Elbow. A. Zerpa (RP) Sixty Day IL - Forearm.

Chicago Cubs:  P. Maton (RP) Sixty Day IL - Knee. E. Cabrera (SP) Fifteen Day IL - Blister. D. Swanson (SS) Ten Day IL - Side. B. Brown (RP) Sixty Day IL - Neck. G. Hollowell (RP) Fifteen Day IL - Shoulder. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

“There’s a lot of things to like. Our defense and baserunning have got to be part of our game every time. The pitching has been great. Offensively, I think with William [Contreras] and [Christian] Yelich much better than they have been recently, that is encouraging. I think there’s good signs, but we need to play with a certain intensity. It will be a great opportunity in a great environment.” - Pat Murphy after his team’s loss against the Rangers in their game on Sunday. 

“To lead off the game, he just has a great at-bat. The ball just explodes off his bat and it’s a no-doubt home run. And then he does it again. He’s making it look a lot easier than it is. I think we’re witnessing something [special].” - Craig Counsell on PCA after his team’s loss against the Reds in their game on Sunday. 

Brice Turang (L) 2B

Garrett Mitchell (L) CF

Jake Bauers (L) 1B

Jackson Chourio (R) LF

Christian Yelich (L) DH

Gary Sánchez (R) C

Sal Frelick (L) RF

David Hamilton (L) 3B

Joey Ortiz (R) SS

Pete Crow-Armstrong (L) CF

Seiya Suzuki (R) RF

Michael Busch (L) 1B

Alex Bregman (R) 3B

Ian Happ (S) LF

Nico Hoerner (R) SS

Pedro Ramírez (S) 2B

Michael Conforto (L) DH

Miguel Amaya (R) C

Batting Average:  Jihwan Bae (.500)

Hits:  William Contreras (131)

Home Runs:  Jake Bauers (23)

RBI:  Brice Turang (78)

Stolen Bases:  David Hamilton (24)

Wins:  Jacob Misiorowski (14)

Saves:  Trevor Megill (25)

ERA:  Easton McGee (0.00)

Batting Average:  Justin Dean (.375)

Hits:  Pete Crow-Armstrong (141)

Home Runs:  Pete Crow-Armstrong (33)

RBI:  Pete Crow-Armstrong (83)

Stolen Bases:  Pete Crow-Armstrong (32)

Wins:  Colin Rea (8)

Saves:  Jacob Webb (9)

ERA:  Ty Blach (0.00)

Managers:

Milwaukee Brewers: Pat Murphy (3rd season)

Chicago Cubs: Craig Counsell (3rd season)