Miami Marlins vs St Louis Cardinals Prediction, Preview and Odds - 06/26/2026

Game Time: 8:15 pm ET, Friday, June 26, 2026

Venue:  Busch Stadium, St. Louis, MO

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Marlins -102, Cardinals -118; Over/Under:  8 runs

Bet365:  Moneyline odds:  Marlins +100, Cardinals -120; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Marlins +100, Cardinals -120; Over/Under:  8 runs

Miami Marlins:  42-39 (3rd place, NL East)

St Louis Cardinals:  42-36 (2nd place, NL Central)

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Miami Marlins:  7-3 last 10

St Louis Cardinals:  4-6 last 10

The Marlins are entering this series off a win and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 42-39 record overall and have a road record of 14-22. This is the series opener of a 3-game series with the Cardinals on Friday and they have Thursday off as a day of rest. Their offense ranks 18th in the MLB with a .713 OPS. Eury Pérez was their starting pitcher on Wednesday while Max Meyer is making his start in this game on Friday. He is 8-0 with a 2.80 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 2 BB with 7 SO on 7 hits through 5 IP against the San Francisco Giants.

The Cardinals lost their 3-game series against the Kansas City Royals 2-1. They enter this game with a 42-36 record overall and have a home record of 22-19. This is the 1st game of a 3-game series with the Marlins on Friday with the series finale of their series against the Arizona Diamondbacks still to be played on Thursday. The Cardinals won the series opener of that series on Monday, lost the 2nd game on Tuesday, and lost the 3rd game on Wednesday. Their offense ranks 14th in the MLB with a .726 OPS. Michael McGreevy is their starting pitcher on Thursday while Dustin May is making his start in this game on Friday. He is 5-6 with a 4.30 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 6 earned runs, 2 homers, and 1 walk with 2 strikeouts on 6 hits through 2 innings pitched against the Kansas City Royals.

The current betting odds have the Marlins listed as a slight underdog in this game according to Draftkings Sportsbook. The Marlins have looked good in their games this season with their 42-39 record overall which has them right in the middle of the NL East. They haven't been a good road team though with their 14-22 road record this year. Meanwhile, the Cardinals have looked good in their games this season with their 42-36 record overall which has them right near the top of the NL Central. They have looked good in their own ballpark too with their 22-19 home record this season. The Cardinals haven't looked good in their games lately though. They are 4-6 in their last 10 games while the Marlins have been rolling lately, going 7-3 in their last 10 games, and this is a pitching matchup that the Marlins can take advantage of. The Cardinals are going with May in this one and he hasn't looked great this season. He is 5-6 with a 4.38 ERA and he has been giving up a lot of runs this year. His team has had more success with him lately, winning 3 games in a row now with him starting, but he did give up 6 earned runs in his last start and that has been a common theme for him. The Marlins are going with Meyer in this one and he has looked great this season. He is 8-0 with a 2.80 ERA and the team has been having a ton of success with him. They have won 4 games in a row now with him starting and he is coming off another great start in which he gave up 2 earned runs, something that has been a common theme for him this year. The Marlins have been the hotter team lately with a solid offense that has been putting up runs lately, so look for them to take advantage of this pitching matchup. The best way to place a bet here is on the Marlins to win this game. 

Marlins Cardinals Prediction:  Our MLB Pick for Friday, June 26, 2026 (8:15 pm ET start time) is Marlins 6 Cardinals 3.

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Miami Marlins: 183-222 (+16.9 units) on the moneyline in all games. 87-111 (+24 units) on the moneyline in road games. 135-173 (+30.2 units) on the moneyline as an underdog of +100 or higher. 14-8 UNDER vs. NL teams allowing 4.5 or more runs/game on the season.

St Louis Cardinals: 81-74 (-18.6 units) on the moneyline as a favorite of -110 or higher. 142-150 (-7 units) on the moneyline against right-handed starters. 130-145 (-8.7 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 8-3 UNDER against NL East opponents.

Miami Marlins:  L. Hicks (C) Ten Day IL - Back. J. Ekness (RP) Sixty Day IL - Calf. A. Nardi (RP) Sixty Day IL - Ribs. J. Junk (SP) Fifteen Day IL - Shin. R. Snelling (SP) Sixty Day IL - Elbow. A. Mazur (SP) Sixty Day IL - Elbow. R. Henriquez (RP) Sixty Day IL - Elbow.

St Louis Cardinals:  R. Urias (3B) Sixty Day IL - Elbow. R. Fernandez (RP) Fifteen Day IL - Back.

“The potential range of time that he could [have been] down was fairly wide and [it was] a unique place where he got injured, and I think that he responded very well to the initial rounds of treatment early on, and it gave us some encouragement.” - Clayton McCullough after his team’s win against the Rangers in their game on Wednesday. 

“They’re in the top of the league in just overall damage against left-handed starters, left-handed pitching in general. So, this was going to be a real test for him. So, the first three [innings] went well, and we just have to solve for the big innings against him. It happens more often than he would like, we would like, and it's something that we have to continue to figure out an answer for.” - Oliver Marmol after his team’s loss against the Diamondbacks in their game on Wednesday. 

Xavier Edwards (S) 2B

Otto Lopez (R) SS

Kyle Stowers (L) 1B

Heriberto Hernández (R) LF

Griffin Conine (L) DH

Jakob Marsee (L) CF

Owen Caissie (L) RF

Leo Jiménez (R) 3B

Brian Navarreto (R) C

JJ Wetherholt (L) 2B

Iván Herrera (R) DH

Jordan Walker (R) RF

Nelson Velázquez (R) LF

José Fermín (R) 3B

Masyn Winn (R) SS

Lars Nootbaar (L) CF

Blaze Jordan (R) 1B

Pedro Pagés (R) C

Batting Average:  Otto Lopez (.340)

Hits:  Otto Lopez (107)

Home Runs:  Liam Hicks (13)

RBI:  Liam Hicks (53)

Stolen Bases:  Jakob Marsee (18)

Wins:  Max Meyer (8)

Saves:  Pete Fairbanks (12)

ERA:  William Kempner (0.00)

Batting Average:  Jordan Walker (.290)

Hits:  Jordan Walker (88)

Home Runs:  Jordan Walker (18)

RBI:  Jordan Walker (58)

Stolen Bases:  Jordan Walker (10)

Wins:  Andre Pallante (9)

Saves:  Riley O'Brien (19)

ERA:  Ryan Fernandez (1.86)

Managers:

Miami Marlins: Clayton McCullough (2nd season)

St Louis Cardinals: Oliver Marmol (5th season)