Miami Marlins vs New York Yankees Prediction, Preview and Odds - 04/04/2026

Game Time: 7:05 pm ET, Saturday, April 4, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Marlins +149, Yankees -181; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Marlins +150, Yankees -180; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Marlins +150, Yankees -180; Over/Under:  8.5 runs

Miami Marlins:  5-1 (1st place, NL East)

New York Yankees:  5-1 (1st place, AL East)

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Miami Marlins:  5-1 last 6

New York Yankees:  5-1 last 6

The Marlins are entering this series off a win and won their 3-game series against the Chicago White Sox 2-1 in their last series. They enter this game with a 5-1 record overall and have a road record of 0-0. This is the 2nd game of a 3-game series with the Yankees on Saturday with the series opener still to be played on Friday. Their offense ranks 1st in the MLB with a .847 OPS. Eury Pérez is their starting pitcher on Friday while Max Meyer is making his start in this game on Saturday. He is 0-0 with a 5.40 ERA this season. His team won their only game this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 0 HR, and 2 BB with 5 SO on 5 hits through 5 IP against the Colorado Rockies.

The Yankees are entering this series off a win and won their 3-game series against the Seattle Mariners 2-1 in their last series. They enter this game with a 5-1 record overall and have a home record of 0-0. This is the 1st game of a 3-game series with the Marlins on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 20th in the MLB with a .646 OPS. Will Warren is their starting pitcher on Friday while Ryan Weathers is making his start in this game on Saturday. He is 0-0 with a 2.08 ERA this season. His team lost their only game this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 2 walks with 7 strikeouts on 4 hits through 4.1 innings pitched against the Seattle Mariners.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked great in their games this season with their 5-1 record overall which has them right at the top of the AL East with the best record in the MLB to start the season. This is also going to be their home opener after a strong performance on the road in the first 2 series' they played. Meanwhile, the Marlins have looked great in their games this season with their 5-1 record overall which has them right at the top of the NL East with the best record in the MLB. They had a great performance at home in their first 2 series' of the year, but now they are playing their first road series. The Marlins were also beating up on 2 of the worst teams in the MLB to start the season, but now they are going on the road against one of the best and the Yankees have a huge pitching advantage in this one. The Yankees are going with Weathers in this one and he looked great in his first start of the year. He only gave up 1 earned run in 4 innings, but the Yankees have shown that they have one of the best bullpens in the MLB to back him up too. They have barely given up any runs this season and that is going to be an issue for the Marlins. The Yankees haven't been great offensively, but they haven't needed the runs either. They are also going to get their runs in this game with Meyer starting for the Marlins. Meyer gave up 3 earned runs in 5 innings his first start of the year and he hasn't been great throughout his short career either. The Marlins had a hot start to the season, but they are going to see a lot of regression in this series as the Yankees look like an early favorite to win the AL. The best way to place a bet here is on the Yankees to win this game and on the runline. 

Marlins Yankees Prediction:  Our MLB Pick for Saturday, April 4, 2026 (7:05 pm ET start time) is Yankees 6 Marlins 1.

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Miami Marlins: 17-17 (+8.2 units) on the moneyline against AL East opponents. 66-83 (+27.2 units) on the moneyline as a road underdog of +100 or higher. 79-103 (+20.1 units) on the moneyline when playing against a team with a winning record. 23-14 OVER as a road underdog of +150 or more.

New York Yankees: 16-18 (-8.3 units) on the moneyline against NL East opponents. 96-67 (-17 units) on the moneyline as a home favorite of -110 or higher. 52-49 (-17.9 units) on the moneyline in an inter-league game. 20-9 OVER vs. NL teams allowing 4.0 or less runs/game on the season.

Miami Marlins:  C. Morel (LF) Ten Day IL - Oblique. A. Mazur (SP) Sixty Day IL - Elbow. E. Ruiz (LF) Ten Day IL - Oblique. K. Stowers (LF) Ten Day IL - Hamstring. M. Acosta (SS) Ten Day IL - Oblique. R. Henriquez (RP) Sixty Day IL - Elbow.

New York Yankees:  G. Cole (SP) Fifteen Day IL - Elbow. C. Rodon (SP) Fifteen Day IL - Elbow. A. Volpe (SS) Ten Day IL - Shoulder. C. Schmidt (SP) Sixty Day IL - Elbow.

“His at-bats have been outstanding. The patience, not missing his pitches. He’s found a couple holes and then really good swing on that last changeup to extend the lead for us on a no-doubter to right-center. He feels dialed in to me and obviously we know what he’s capable of.” - Aaron Boone on Ben Rice after his team’s win against the Mariners in their game on Wednesday. 

“Many negative things happened last year but that didn’t hold me back trying to be better. This year, I am going to give my best every time, win more games and be more aggressive in counts. Today, as a club, we did a tremendous job.” - Sandy Alcantara after their win against the White Sox in their game on Wednesday.

Jakob Marsee (L) CF

Xavier Edwards (S) 2B

Agustín Ramírez (R) DH

Liam Hicks (L) C

Otto Lopez (R) SS

Owen Caissie (L) RF

Connor Norby (R) 1B

Griffin Conine (L) LF

Graham Pauley (L) 3B

Trent Grisham (L) CF

Aaron Judge (R) RF

Cody Bellinger (L) LF

Ben Rice (L) 1B

Giancarlo Stanton (R) DH

Jazz Chisholm Jr. (L) 2B

Austin Wells (L) C

José Caballero (R) SS

Ryan McMahon (L) 3B

Batting Average:  Liam Hicks (.467)

Hits:  Xavier Edwards (9)

Home Runs:  Liam Hicks (3)

RBI:  Liam Hicks (12)

Stolen Bases:  Owen Caissie (1)

Wins:  Sandy Alcantara (2)

Saves:  Pete Fairbanks (2)

ERA:  Sandy Alcantara (0.00)

Batting Average:  Giancarlo Stanton (.500)

Hits:  Giancarlo Stanton (10)

Home Runs:  Aaron Judge (2)

RBI:  Ben Rice (5)

Stolen Bases:  Cody Bellinger (2)

Wins:  Max Fried (2)

Saves:  David Bednar (3)

ERA:  Max Fried (0.00)

Managers:

Miami Marlins: Clayton McCullough (2nd season)

New York Yankees: Aaron Boone (9th season)