by Rod Pearson
Wednesday, Nov 26, 2025
Game Time: 3:30 pm ET, Saturday, November 29, 2025
Venue: Gaylord Family - Oklahoma Memorial Stadium, Norman, OK
Where to Watch: ABC
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: LSU +10, Oklahoma -10; Over/Under: 36.5 points
Bet365: Point Spread: LSU +10, Oklahoma -10; Over/Under: 36.5 points
BetMGM: Point Spread: LSU +10, Oklahoma -10; Over/Under: 36.5 points
Season Record
LSU Tigers: 7-4 (3-4) (10th place, SEC)
Oklahoma Sooners: 9-2 (5-2) (6th place, SEC)
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Recent Form
LSU Tigers: won their last game at home against the Western Kentucky Hilltoppers 13-10.
Oklahoma Sooners: won their last game at home against the Missouri Tigers 17-6.
LSU Tigers vs Oklahoma Sooners Preview and Analysis
LSU is entering this game with a 7-4 record overall and they have a 3-4 record in their conference games too. They are 6-1 in their home games, 1-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Western Kentucky 13-10. Michael Van Buren Jr. was the starting QB and he completed 25/42 passes for 202 passing yards, 1 touchdown, and 1 interception. Harlem Berry led the team in rushing yards with 80. Zavion Thomas led the receivers with 47 receiving yards on 6 receptions. A.J. Haulcy led the defense in that game with 5 solo tackles and 4 assisted tackles while Jimari Butler led the defense in sacks with 2. DJ Pickett and PJ Woodland each came away with 1 interception for them in that one.
Oklahoma is entering this game with a 9-2 record overall and they have a 5-2 record in their conference games too. They are 5-1 in their home games, 4-0 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against Missouri 17-6. John Mateer was the starting QB and he completed 14/30 passes for 173 passing yards, 2 touchdowns, and 0 interceptions. John Mateer led the team in rushing yards with 60. Isaiah Sategna led the receivers with 109 receiving yards on 3 receptions and 1 TD. Reggie Powers III and Michael Boganowski each led the defense in that game with 3 solo tackles and 2 assisted tackles while Taylor Wein led the defense in sacks with 1.5. Eli Bowen and Jacobe Johnson each came away with 1 interception for them in that one.
LSU vs Oklahoma Prediction
The current betting odds have Oklahoma listed as a 10 point favorite in this game according to Draftkings Sportsbook. Oklahoma has looked really good in their games this season with their 9-2 record overall and their 5-2 conference record which has them in the top half of the SEC. They have looked great on their home field too with their 5-1 home record this season. Meanwhile, LSU has looked good in their games this season with their 7-4 record overall, but their 3-4 conference record has them in the bottom half of the SEC. They haven't been a good road team this year either with their 1-3 road record. LSU has had a very disappointing season and ended up firing Brian Kelly weeks ago. The defense has looked good at times, but the offense has been a disaster. They have one of the worst offenses in the SEC this year, off a 13-10 win over Western Kentucky in their last one, and they struggled to put up points against LA Tech earlier this season too. They have struggled all year against bad defenses, but now they have to go on the road against one of the best defenses in the SEC and they aren't going to get much done on offense here. Oklahoma is off a 17-6 win over Missouri in their last one and their offense hasn't looked great at times, but their defense has been showing up in every game and doesn't give up many points at all. Even if the offense struggles here, the defense is going to keep this terrible LSU offense off the board long enough for Oklahoma to put up points and build a lead. Oklahoma also needs the win more for their playoff resume so expect them to bring their best effort to close out the regular season at home. The best way to place a bet here is on Oklahoma to cover the spread in this game.
LSU Oklahoma Prediction: Our NCAAF Pick for Saturday, November 29, 2025 (3:30 pm ET start time) is Oklahoma 20 LSU 6.
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NCAAF Betting Trends
LSU Tigers: 1-5 ATS as a road underdog. 2-9 ATS when playing against a top-level team (Win Pct. > 75%). 5-9 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 7-1 OVER versus good rushing defenses - allowing 3.25 rushing yards/carry or less.
Oklahoma Sooners: 11-5 ATS as a home favorite. 21-10 ATS as a home favorite of 7.5 to 14 points. 28-18 ATS at home after a game with a turnover margin of +2 or better. 3-0 OVER as a home favorite of 7.5 to 14 points.
Key Injuries
LSU Tigers: C. Durham (RB) Questionable - Neck. G. Nussmeier (QB) Doubtful - Undisclosed. M. Delane (CB) Questionable - Undisclosed. N. Anderson (WR) Questionable - Undisclosed. A. Anderson (WR) Questionable - Undisclosed. T. Adams (OG) Questionable - Undisclosed. G. Reliford (DL) Questionable - Undisclosed. J. Lindsey (RB) Out - Suspension.
Oklahoma Sooners: K. Dolby (CB) Questionable - Undisclosed. H. Ozaeta (OG) Questionable - Undisclosed. G. Williams (CB) Questionable - Undisclosed. J. Taylor (OG) Questionable - Undisclosed. J. Sexton (OG) Questionable - Undisclosed. J. Barnes (RB) Questionable - Undisclosed. T. Everett (OG) Out - Undisclosed.
Notable Quotes
“It took us a moment to really settle in but once we did and the game got into the second half, we were absolutely dominant defensively. I thought our defense played lights out.” - Frank Wilson after his team’s win against WKU in their last game.
“Show back up ready to go. Renew your spirit, get your get your mind right. Enjoy tonight and stay humble, stay thankful, stay hungry and get ready to go back at it again here on Monday.” - Brent Venables after his team’s win against Mizzou in their last game.
Starting Lineups
LSU Tigers
WR Thomas, Zavion
WR Brown, Barion
WR Anderson, Aaron
TE Sharp, Bauer
QB Nussmeier, Garrett
RB Durham, Caden
Oklahoma Sooners
WR Lewis, Keontez
WR Burks, Deion
WR Sategna III, Isaiah
TE Kanak, Jaren
QB Mateer, John
RB Blaylock, Tory
Statistical Leaders
LSU Tigers
Passing: Garrett Nussmeier (1,927)
Rushing: Caden Durham (463)
Receiving: Barion Brown (486)
Touchdowns: Trey'Dez Green (5)
Oklahoma Sooners
Passing: John Mateer (2,260)
Rushing: Xavier Robinson (408)
Receiving: Isaiah Sategna III (827)
Touchdowns: John Mateer (7)
Coaches:
LSU Tigers: Frank Wilson (Interim)
Oklahoma Sooners: Brent Venables (4th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
