by Rod Pearson
Monday, Oct 27, 2025
Game Time: 3:00 pm ET, Saturday, November 1, 2025
Venue: Lane Stadium, Blacksburg, VA
Where to Watch: The CW Network
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Louisville -10, VA Tech +10; Over/Under: 53.5 points
Bet365: Point Spread: Louisville -10, VA Tech +10; Over/Under: 53.5 points
BetMGM: Point Spread: Louisville -10, VA Tech +10; Over/Under: 54.5 points
Season Record
Louisville Cardinals: 6-1 (3-1) (4th place, ACC)
Virginia Tech Hokies: 3-5 (2-2) (10th place, ACC)
Do not miss out on our expert handicapper analysis! Sean Murphy is on a HOT STREAK in college football on a 6-0 CFB RUN for +$6,000 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.
Recent Form
Louisville Cardinals: won their last game at home against the Boston College Eagles 38-24.
Virginia Tech Hokies: won their last game at home against the California Golden Bears 42-34 in overtime.
Louisville Cardinals vs Virginia Tech Hokies Preview and Analysis
Louisville is entering this game with a 6-1 record overall and they have a 3-1 record in their conference games too. They are 4-1 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Boston College 38-24. Miller Moss was the starting QB and he completed 15/27 passes for 187 passing yards, 1 touchdown, and 1 interception. Isaac Brown led the team in rushing yards with 205 and 1 TD. Chris Bell led the receivers with 49 receiving yards on 4 receptions. Kalib Perry led the defense in that game with 8 solo tackles and 3 assisted tackles while Wesley Bailey led the defense in sacks with 2. Kalib Perry and Jordan Guerad each came away with 1 interception for them in that one.
Virginia Tech is entering this game with a 3-5 record overall and they have a 2-2 record in their conference games too. They are 2-3 in their home games, 1-1 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against California 42-34 in OT. Kyron Drones was the starting QB and he completed 9/18 passes for 119 passing yards, 3 touchdowns, and 1 interception. Marcellous Hawkins led the team in rushing yards with 167. Takye Heath led the receivers with 64 receiving yards on 4 receptions and 2 TDs. Kemari Copeland led the defense in that game with 4 solo tackles and 3 assisted tackles while Kemari Copeland led the defense in sacks with 3. No one on the defense came away with an interception for them in that one.
Louisville vs Virginia Tech Prediction
The current betting odds have Louisville listed as a 10 point favorite in this game according to Draftkings Sportsbook. Louisville has looked great in their games this season with their 6-1 record overall and their 3-1 conference record which has them higher in the ACC. Their only loss this year was against Virginia, but that loss has been aging well with Virginia looking like a top 25 team in the nation. Louisville also has a big upset win over Miami so they have a real shot at the ACC Championship and are playing with a ton of momentum, off a 38-24 win over Boston College in their last one. Meanwhile, Virginia Tech hasn't looked good in their games this season with their 3-5 record overall and their 2-2 conference record which has them lower in the ACC. They are off a nice 42-34 win over California in their last one, but they didn't look great for a lot of that game. They needed a big comeback win in that game and were fortunate to win it in OT. They have already fired their head coach this season and their defense has been a big issue too. Their offense looked a lot better in their last one, but their offense has struggled for most of the season and they aren't going to be able to do much here against a much better Louisville defense. VA Tech picked up a nice home win last week, but they don't have the talent to compete with Louisville here so look for Louisville to continue rolling in this one. The best way to place a bet here is on Louisville to cover the spread in this game.
Louisville Virginia Tech Prediction: Our NCAAF Pick for Saturday, November 1, 2025 (3:00 pm ET start time) is Louisville 38 VA Tech 21.
Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Louisville Cardinals Virginia Tech Hokies prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.
NCAAF Betting Trends
Louisville Cardinals: 5-10 ATS as a favorite of 3.5 to 10 points. 0-4 ATS vs. poor passing defenses - allowing 8 or more passing yards/att. 12-5 OVER when the total is between 49.5 and 56. 6-0 OVER when playing against a team with a losing record.
Virginia Tech Hokies: 13-7 ATS against conference opponents. 4-1 ATS versus good rushing defenses - allowing 3.25 rushing yards/carry or less. 11-6 OVER in home lined games. 13-7 OVER against conference opponents.
Key Injuries
Louisville Cardinals: J. Wilder (RB) Questionable - Undisclosed. D. Watson (RB) Questionable - Undisclosed. K. Hughes (WR) Questionable - Undisclosed. S. Gates (RB) Questionable - Undisclosed. T. Folmar (OG) Questionable - Undisclosed. T. Egan (QB) Questionable - Undisclosed. S. Clark (LB) Out - Ankle.
Virginia Tech Hokies: B. Meadows (OG) Questionable - Undisclosed. C. Wiggins (WR) Questionable - Undisclosed. K. Adams (WR) Questionable - Undisclosed. C. Brown (CB) Questionable - Undisclosed. Q. Reddish (S) Questionable - Undisclosed. J. Overton Jr. (RB) Questionable - Undisclosed. B. Bennett (RB) Questionable - Undisclosed. J. Clarke (CB) Questionable - Undisclosed. J. Hobbs (WR) Questionable - Undisclosed. L. Booker (WR) Questionable - Undisclosed. A. Hanchuk (DL) Questionable - Undisclosed. S. Henderson (DL) Questionable - Undisclosed. J. Jennette (DL) Questionable - Undisclosed. M. Cunningham (OG) Questionable - Undisclosed. S. Covil (S) Questionable - Undisclosed.
Notable Quotes
“Even when things aren’t super efficient, and super smooth, we hang in there. We try to make adjustments. Some of them work, some of them don’t, but our guys responded.” - Jeff Brohm after his team’s win against BC in their last game.
“We knew it was going to take all three phases to get it done. In the second half, our guys continued to battle, continued to fight, and they were resilient all game long. I just couldn’t be more proud of our football team and our coaching staff, with the way they’ve welded together and stayed together. Boy, what a big win. The joy in that locker room was unbelievable. The good Lord has blessed us in that way, and I’m just really proud of this team and how hard they fought tonight and how hard they’ve been fighting.” - Philip Montgomery after his team’s win against Cal in their last game.
Starting Lineups
Louisville Cardinals
WR Hurry, TreyShun
WR Bell, Chris
WR Lacy, Caullin
TE Kurisky, Nate
QB Moss, Miller
RB Brown, Isaac
Virginia Tech Hokies
WR Greene, Donavon
WR Greene, Ayden
WR Seldon, Cameron
TE Gosnell, Benji
QB Drones, Kyron
RB Hawkins, Marcellous
Statistical Leaders
Louisville Cardinals
Passing: Miller Moss (1,793)
Rushing: Isaac Brown (652)
Receiving: Chris Bell (687)
Touchdowns: Chris Bell (6)
Virginia Tech Hokies
Passing: Kyron Drones (1,516)
Rushing: Marcellous Hawkins (531)
Receiving: Ayden Greene (365)
Touchdowns: Kyron Drones (7)
Coaches:
Louisville Cardinals: Jeff Brohm (3rd season)
Virginia Tech Hokies: Philip Montgomery (Interim)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
