by Rod Pearson
Friday, Nov 11, 2022
Game Time: 3:30 pm ET, Saturday, November 12, 2022
Venue: Memorial Stadium, Clemson, SC
Where to Watch: ESPN
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Louisville +7, Clemson -7; Over/Under: 51.5 points
Bet365: Point Spread: Louisville +7, Clemson -7; Over/Under: 51.5 points
BetMGM: Point Spread: Louisville +7, Clemson -7; Over/Under: 51.5 points
Season Record
Louisville Cardinals: 6-3 (3-3) (5th place, ACC Atlantic)
Clemson Tigers: 8-1 (6-0) (1st place, ACC Atlantic)
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Recent Form
Louisville Cardinals: won their last game at home against the James Madison Dukes 34-10.
Clemson Tigers: lost their last game on the road against the Notre Dame Fighting Irish 35-14.
Louisville Cardinals vs Clemson Tigers Preview and Analysis
Louisville is entering this game with a 6-3 record overall to start their college football season and they will be playing their 5th road game of the season here as they are 2-2 in their road games this year. This will also be their 7th conference game of the college football season this year as they are 3-3. They won against the James Madison Dukes in their last game at home 34-10. Malik Cunningham started that game at QB and he completed 14/20 passes for 223 yards and 3 touchdowns. Tiyon Evans led the team in rushing with 126 yards and 1 TD on 10 rushing attempts while Jawhar Jordan had 117 yards on 17 carries. Tyler Hudson led the team in receiving with 142 yards and 1 TD on 6 receptions. Mohamed Sanogo led the defense in that game with 5 solo tackles and 8 assisted tackles. No one on the defense recorded a sack for them while no one on the defense came away with an interception in that one.
Clemson is entering this game with an 8-1 record overall to start their college football season and they will be playing their 5th home game of the season as they are 4-0 in their home games this year. This will also be the 7th conference matchup on their conference schedule this season as they are 6-0. They lost against the Notre Dame Fighting Irish in their last game on the road 35-14. DJ Uiagalelei started that game at QB and he completed 27/39 passes for 191 yards, 1 touchdown, and 1 interception. Will Shipley led the team in rushing with 63 yards and 1 TD on 12 carries. Davis Allen led the team in receiving with 60 yards on 7 receptions. Jalyn Phillips led the defense in that game with 6 solo tackles and 2 assisted tackles. Myles Murphy led the defense in sacks with 1 while no one on the defense came away with an interception for them in that one.
Louisville vs Clemson Prediction
The current betting odds have Clemson listed as a 7 point favorite in this game according to Draftkings Sportsbook. Clemson just took a really bad loss in their last game to Notre Dame. They were blown out on the road by over 20 points in a non-conference game and not only did it hand Clemson their 1st loss of the season, but it knocked them out of the college football playoffs as they went from number 4 in the country down to number 10 in the country. That loss may have just killed their chances to get back in the top 4 but just in case it didn't, Clemson cannot afford to take anymore chances in their last few games and will be looking to bounce back with a blowout win here. Louisville has been struggling a lot this season as they have been terrible in conference play and their defense has been giving up a lot of points in every game. Their offense can put up points too but they have been very inconsistent in their games this year and Clemson has a good defense that could easily shut Louisville down here with how up and down they have been. Clemson is going to be looking to respond to that loss last week with a big win here at home. The best way to place a bet here is on Clemson to cover the spread in this game.
Louisville Clemson Prediction: Our NCAAF Pick for Saturday, November 12, 2022 (3:30 pm ET start time) is Clemson 31 Louisville 10.
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NCAAF Betting Trends
Louisville Cardinals: 20-15 ATS as a road underdog of 7 points or less. 31-23 OVER as a road underdog. 14-5 OVER in a road game where the total is between 49.5 and 52.
Clemson Tigers: 2-11 ATS when the total is between 49.5 and 56. 5-11 ATS in home games. 9-0 OVER as a favorite of 3.5 to 10 points.
Key Injuries
Louisville Cardinals: E. Conley (QB) Out indefinitely - Hip. T. Cooley (RB) Ques Sat - Personal. D. Wiggins (WR) out of season - Toe. J. Lole (DL) out for season - Elbow.
Clemson Tigers: K. Pace (RB) Mid Nov - Ankle. J. Foster (DE) Out indefinitely - Undisclosed. T. Stellato (WR) out for season - Knee.
Notable Quotes
“They have a 38-game home winning streak, we know that. It’s obviously a tough place to go play and try to get a win. We’ll have to prepare for that, particularly on offense.” - Scott Satterfield on this upcoming game against Clemson.
"We gave up a score on offense, a score on special teams and a score on defense and that's the first time that's happened since I was a head coach. We just got outcoached in every aspect of football. I wish I could say I saw it coming, but we had a great week of practice, a great week of preparation. But football's a crazy game." - Dabo Swinney after his team’s loss against Notre Dame in their last game.
Starting Lineups
Louisville Cardinals
WR Hudson, Tyler
WR Huggins-Bruce, Ahmari
WR Smith, Braden
TE Melton, Dez
HB Ford, Marshon
QB Cunningham, Malik
RB Evans, Tiyon
Clemson Tigers
WR Ngata, Joseph
WR Williams, E.J.
WR Williams, Antonio
TE Allen, Davis
TE Briningstool, Jake
QB Uiagalelei, DJ
RB Shipley, Will
Statistical Leaders
Louisville Cardinals
Passing: M. Cunningham (1471)
Rushing: M. Cunningham (541)
Receiving: T. Hudson (703)
Touchdowns: M. Cunningham (11)
Clemson Tigers
Passing: D. Uiagalelei (1994)
Rushing: W. Shipley (802)
Receiving: A. Williams (390)
Touchdowns: W. Shipley (11)
Coaches:
Louisville Cardinals: Scott Satterfield (4th season)
Clemson Tigers: Dabo Swinney (15th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
