Louisville Cardinals vs Arkansas Razorbacks Prediction, Picks and Game Preview - 12/03/2025

Game Time: 7:15 pm ET, Wednesday, December 3, 2025

Venue:  Bud Walton Arena, Fayetteville, AR

Where to Watch:  ESPN

DraftKings:  Point Spread:  Louisville -3.5, Arkansas +3.5; Over/Under:  164.5 points

Bet365:  Point Spread:  Louisville -3.5, Arkansas +3.5; Over/Under:  164.5 points

BetMGM:  Point Spread:  Louisville -3.5, Arkansas +3.5; Over/Under:  164.5 points

Louisville Cardinals:  7-0 (0-0) (3rd place, ACC)

Arkansas Razorbacks:  5-2 (0-0) (10th place, SEC)

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Louisville Cardinals:  5-0  last 5

Arkansas Razorbacks:  4-1  last 5

Louisville is entering this game with a 7-0 record overall, a 0-0 record in conference games, and they are 0-0 in their road games this season where they will be in this game. They are coming off a win against the NJIT Highlanders in their last game. Ryan Conwell led the team in points in that game with 32 while Isaac McKneely was next on the team with 17. Mikel Brown Jr. led the team in assists with 7 in that game while Ryan Conwell and Kobe Rodgers each led the team in rebounds with 9. They were 49.3% from the field, 41.7% from 3-point range, and 85.7% from the free throw line with their shooting in that game. Their offense is averaging 96.7 PPG and their defense is allowing their opponents to average 63 PPG against them. Louisville has an ATS record of 5-2 this season and their O/U record is 3-4.

Arkansas is entering this game with a 5-2 record overall, a 0-0 conference record, and they are 5-0 in their home games this season where they will be in this game. They are coming off a loss against the Duke Blue Devils in their last game. Darius Acuff led the team in points in that game with 21 while Meleek Thomas was next on the team with 13. Darius Acuff led the team in assists with 5 in that game while Trevon Brazile led the team in rebounds with 11. They were 40.6% from the field, 33.3% from 3-point range, and 81.8% from the free throw line with their shooting in that game. Their offense is averaging 88.1 PPG and their defense is allowing their opponents to average 71.6 PPG against them. Arkansas has an ATS record of 4-3 this season and their O/U record is 2-5.

The current betting odds have Louisville listed as a 3.5 point favorite in this game according to Draftkings Sportsbook. Louisville has looked great in their games this season with their 7-0 record overall which has them right near the top of the ACC and ranked inside the top 25. This is going to be their first road game of the season too. Meanwhile, Arkansas has looked good in their games this season with their 5-2 record overall which has them ranked inside the top 25, but those 2 losses do have them lower in the SEC at the moment. They have looked a lot better on their home court though with their 5-0 home record this year. Arkansas hasn't had the best start to the season though, losing their only 2 games against ranked opponents. They are off a loss to Duke in their last one and they didn't look terrible in that loss, but they still lost the game by 9 points in the end and were always at an arm's length. Now they are back at home where they have looked a lot better this year and taking on Louisville in their 1st road game of the year, but Louisville still has a lot more talent this season as they look like one of the best in the nation, and this team isn't where Calipari wants his team to be at the moment. Louisville has only played 1 ranked opponent this year, but they blew Kentucky out in that game and this is a game they should be able to dominate on the road with the talent they have. The best way to place a bet here is on Louisville to cover the spread in this game. 

Louisville Arkansas Prediction:  Our NCAAB Pick for Wednesday, December 3, 2025 (7:15 pm ET start time) is Louisville 87 Arkansas 81.

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Louisville Cardinals: 14-8 ATS in road games. 15-8 ATS after 3 or more consecutive wins. 22-16 ATS after playing a home game. 5-2 OVER after successfully covering the spread in 3 or more consecutive games.

Arkansas Razorbacks: 3-7 ATS ersus good foul drawing teams - attempting 25 free throws/game or more. 3-7 ATS versus teams who average 9 or more steals/game on the season. 9-16 ATS when playing only their 2nd game in 8 days. 23-15 OVER in all home games.

Louisville Cardinals:  K. Pryor (F) Questionable - Concussion.

Arkansas Razorbacks:  None.

"Obviously, it's going to be a great college basketball atmosphere. The arena is going to be hopping, so the lights are going to be bright. It's going to be a big stage, and we're really excited about the opportunity going against one of the most talented teams in the country." - Pat Kelsey on his team’s upcoming game against Arkansas. 

“I always come back to, when it’s like that and they’re doing everything they can, then I’ve got to make more of a difference in the game. We’ve been working on some things. How do we play the last two minutes? There are things that I’ve done in the past, maybe I’ve got to do different.” - John Calipari on his team this season.

M. Brown 

R. Conwell 

S. Fru 

J. Hadley 

I. McKneely

D. Acuff 

T. Brazile 

K. Knox 

N. Pringle 

D. Wagner

PPG: Ryan Conwell (20.1)

APG: Mikel Brown Jr. (6)

Reb/G: Sananda Fru (5.9)

PPG: Meleek Thomas (17.6)

APG: Darius Acuff Jr. (4.4)

Reb/G: Trevon Brazile (7.7)

Coaches:

Louisville Cardinals: Pat Kelsey (2nd season)

Arkansas Razorbacks: John Calipari (2nd season)