by Rod Pearson
Friday, Nov 07, 2025
Game Time: 4:25 pm ET, Sunday, November 9, 2025
Venue: Levi's Stadium, Santa Clara, CA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Rams -4.5, 49ers +4.5; Over/Under: 49.5 points
Bet365: Point Spread: Rams -4.5, 49ers +4.5; Over/Under: 49.5 points
BetMGM: Point Spread: Rams -4.5, 49ers +4.5; Over/Under: 49.5 points
Season Record
Los Angeles Rams: 6-2 (2nd place, NFC West)
San Francisco 49ers: 6-3 (3rd place, NFC West)
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Los Angeles Rams: won their last game at home against the New Orleans Saints 34-10.
San Francisco 49ers: won their last game on the road against the New York Giants 34-24.
Los Angeles Rams vs San Francisco 49ers Preview and Analysis
The Rams are entering this game with a 6-2 record overall and they have a 0-1 record in their divisional games too. They are 3-1 in their home games, 2-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New Orleans Saints 34-10. Matthew Stafford was the starting QB and he completed 24/32 passes for 281 passing yards, 4 touchdowns, and 0 interceptions. Kyren Williams led the team in rushing yards with 114 and 1 TD. Puka Nacua led the receivers with 95 receiving yards on 7 receptions and 1 TD. Kamren Kinchens led the defense in that game with 4 solo tackles and 0 assisted tackles while Braden Fiske led the defense in sacks with 1. Emmanuel Forbes Jr. came away with the only interception for them in that one.
The 49ers are entering this game with a 6-3 record overall and they have a 3-0 record in their divisional games too. They are 2-1 in their home games, 4-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New York Giants 34-24. Mac Jones was the starting QB and he completed 19/24 passes for 235 passing yards, 2 touchdowns, and 0 interceptions. Christian McCaffrey led the team in rushing yards with 106 and 1 TD. Christian McCaffrey led the receivers with 67 receiving yards on 5 receptions and 1 TD. Tatum Bethune led the defense in that game with 8 solo tackles and 8 assisted tackles while Sam Okuayinonu and Clelin Ferrell each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Rams vs 49ers Prediction
The current betting odds have the 49ers listed as a 4.5 point underdog in this game according to Draftkings Sportsbook. The 49ers have looked good in their games this season with their 6-3 record overall, but that record has them near the bottom of the NFC West in a competitive division. They do have a big advantage though as they are 3-0 in the NFC West so this is a big game for them in the division. Meanwhile, the Rams have looked really good in their games this season with their 6-2 record overall which has them right near the top of the NFC West. They are off a 34-10 win over the Saints in their last one and they have been rolling over their opponents in their games lately. Their defense hasn't been giving up many points while their offense has been putting up a ton, but they have also had a really weak schedule lately. This is a big game for them since they are 0-1 in the NFC West, but that loss was against the 49ers in a game where they were a big favorite. The 49ers pulled off the upset on the road and now they have the home advantage on their side here, also getting healthier with some players coming back. These two always play a really tight game and even though the Rams will be looking for revenge here, look for the 49ers to once again keep it a tight game at home. The best way to place a bet here is on the 49ers to cover the spread in this game.
Rams 49ers Prediction: Our NFL Pick for Sunday, November 9, 2025 (4:25 pm ET start time) is Rams 23 49ers 20.
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NFL Betting Trends
Los Angeles Rams: 27-16 ATS in all games. 8-1 ATS as a road favorite of 7 points or less. 8-2 ATS after allowing 14 points or less last game. 9-3 OVER off a home win. 5-1 OVER revenging a home loss against an opponent.
San Francisco 49ers: 1-5 ATS as an underdog of 3.5 to 9.5 points. 2-9 ATS in a home game where the total is greater than or equal to 45.5. 4-11 ATS after scoring 30 points or more last game. 26-18 OVER in all games. 5-1 OVER as an underdog of 3.5 to 9.5 points.
Key Injuries
Los Angeles Rams: D. Williams (CB) Injured - Shoulder. P. Nacua (WR) Injured - Chest. J. Whittington (WR) Injured - Back.
San Francisco 49ers: K. Davis (DL) Injured - Ankle. K. White (DL) Injured - Groin. A. Collins (DL) Injured - Hip. T. Williams (OT) Injured - Rest. J. Brendel (OG) Injured - Hamstring. C. McCaffrey (RB) Injured - Rest. M. Jones (QB) Injured - Knee. B. Huff (DL) Injured - Hamstring. J. Jennings (WR) Injured - Ankle. B. Purdy (QB) Injured - Toe. D. Winters (LB) Injured - Knee. B. Bartch (OG) Injured - Ankle. D. Luter Jr. (CB) Injured - Achilles. T. Bethune (LB) Injured - Thigh. R. Pearsall (WR) Injured - Knee. M. Williams (DL) Injured - Knee.
Notable Quotes
"Happy for them, and we'll see if we can continue to do some good stuff like they did. They inspire me, and I know they inspire our group." - Sean McVay on the LA Dodgers after his team’s win against the Saints in their last game.
“Collectively as a team, we were able to stick with it. It was a huge team deal getting those run calls.” - Kyle Shanahan after his team’s win against the Giants in their last game.
Starting Lineups
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Smith, Xavier
TE Higbee, Tyler
QB Stafford, Matthew
RB Williams, Kyren
San Francisco 49ers
WR Bourne, Kendrick
WR Pearsall, Ricky
WR Jennings, Jauan
TE Kittle, George
QB Jones, Mac
RB McCaffrey, Christian
FB Juszczyk, Kyle
Statistical Leaders
Los Angeles Rams
Passing: Matthew Stafford (2,147)
Rushing: Kyren Williams (586)
Receiving: Puka Nacua (711)
Touchdowns: Davante Adams (8)
San Francisco 49ers
Passing: Mac Jones (1,832)
Rushing: Christian McCaffrey (596)
Receiving: Christian McCaffrey (626)
Touchdowns: Christian McCaffrey (8)
Coaches:
Los Angeles Rams: Sean McVay (9th season)
San Francisco 49ers: Kyle Shanahan (9th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
