by Rod Pearson
Tuesday, Nov 25, 2025
Game Time: 1:00 pm ET, Sunday, November 30, 2025
Venue: Bank of America Stadium, Charlotte, NC
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Rams -10.5, Panthers +10.5; Over/Under: 44.5 points
Bet365: Point Spread: Rams -10.5, Panthers +10.5; Over/Under: 45 points
BetMGM: Point Spread: Rams -10, Panthers +10; Over/Under: 45 points
Season Record
Los Angeles Rams: 9-2 (1st place, NFC West)
Carolina Panthers: 6-6 (2nd place, NFC South)
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Los Angeles Rams: won their last game at home against the Tampa Bay Buccaneers 34-7.
Carolina Panthers: lost their last game on the road against the San Francisco 49ers 20-9.
Los Angeles Rams vs Carolina Panthers Preview and Analysis
The Rams are entering this game with a 9-2 record overall and they have a 2-1 record in their divisional games too. They are 5-1 in their home games, 3-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Tampa Bay Buccaneers 34-7. Matthew Stafford was the starting QB and he completed 25/35 passes for 273 passing yards, 3 touchdowns, and 0 interceptions. Kyren Williams led the team in rushing yards with 46. Puka Nacua led the receivers with 97 receiving yards on 7 receptions. Kamren Curl led the defense in that game with 6 solo tackles and 2 assisted tackles while Kobie Turner and Jared Verse each led the defense in sacks with 2. Cobie Durant and Emmanuel Forbes Jr. each came away with 1 interception for them in that one.
The Panthers are entering this game with a 6-6 record overall and they have a 2-1 record in their divisional games too. They are 3-2 in their home games, 3-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the San Francisco 49ers 20-9. Bryce Young was the starting QB and he completed 18/29 passes for 169 passing yards, 1 touchdown, and 2 interceptions. Rico Dowdle led the team in rushing yards with 38. Rico Dowdle led the receivers with 36 receiving yards on 4 receptions. Tre'von Moehrig led the defense in that game with 4 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. Jaycee Horn came away with 2 interceptions for them while Mike Jackson came away with 1 INT in that one.
Rams vs Panthers Prediction
The current betting odds have the Rams listed as a 10.5 point favorite in this game according to Draftkings Sportsbook. The Rams have looked great in their games this season with their 9-2 record overall which has them right at the top of the NFC West with one of the best records in the entire NFL. They have also been a good road team this year with their 3-1 road record. Meanwhile, the Panthers have looked good in their games this season with their 6-6 record overall which has them right near the top of the NFC South. They have looked better on their home field too with their 3-2 home record this season. The Panthers have been a big surprise this season, showing a lot of improvement and picking up some impressive wins this year. They are off a 20-9 loss to the 49ers in their last one and the offense didn't look good. They turned the ball over a lot against a good 49ers defense and they struggled to play from behind too. Now they are facing an even better defense in the Rams and the Rams have been blowing teams out all year. The Rams have been rolling in their games lately with 6 wins in a row now and they are off a 34-7 win over the Buccaneers in their last one, embarrassing some good teams too. They have one of the best defenses in the NFL that just hasn't been giving up many points lately, and Stafford is making a case for the MVP with the way he has been leading that offense. The Rams have too much talent on offense for the Panthers defense to handle and once they fall behind here, they are going to struggle to play from behind. The best way to place a bet here is on the Rams to cover the spread in this game.
Rams Panthers Prediction: Our NFL Pick for Sunday, November 30, 2025 (1:00 pm ET start time) is Rams 31 Panthers 10.
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NFL Betting Trends
Los Angeles Rams: 29-17 ATS in all games. 9-1 ATS as a road favorite. 9-2 ATS after allowing 14 points or less last game. 17-9 UNDER as a favorite. 11-1 UNDER versus poor defensive teams - allowing 5.65 yards/play or more.
Carolina Panthers: 5-11 ATS vs. good passing teams averaging 235 or more passing yards/game. 5-9 ATS vs. good passing teams averaging 7 or more passing yards/att. 3-10 ATS when playing against a team with a winning record. 4-1 UNDER after a 2 game road trip.
Key Injuries
Los Angeles Rams: D. Quessenberry (OG) Injured - Groin. A. Witherspoon (CB) Injured - Shoulder. X. Smith (WR) Injured - Concussion. T. Atwell (WR) Injured - Hamstring. B. Young (LB) Injured - Knee. K. Kinchens (S) Injured - Shoulder. K. Mumpfield (WR) Injured - Calf.
Carolina Panthers: C. Cherelus (LB) Injured - Concussion. C. Mays (C) Injured - Ankle. J. Horn (CB) Injured - Concussion. C. Rozeboom (LB) Injured - Hip. C. Zavala (OG) Injured - Calf. T. Wallace (LB) Injured - Shoulder.
Notable Quotes
“The only (way) that would matter is if the season ended right now. Do you remember who was in first place with six weeks left last year? Me neither. But this team has fun, and good football is fun, and when you're doing it with good people that you don't want to let down, that's really fun.” - Sean McVay after his team’s win against the Buccaneers in their last game.
“I like the call. It was an aggressive call, a play action that we had opportunities on. Unfortunately came out with an interception.” - Dave Canales after his team’s loss against the 49ers in their last game.
Starting Lineups
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Whittington, Jordan
TE Parkinson, Colby
QB Stafford, Matthew
RB Williams, Kyren
Carolina Panthers
WR McMillan, Tetairoa
WR Legette, Xavier
WR Coker, Jalen
TE Tremble, Tommy
QB Young, Bryce
RB Dowdle, Rico
Statistical Leaders
Los Angeles Rams
Passing: Matthew Stafford (2,830)
Rushing: Kyren Williams (796)
Receiving: Puka Nacua (947)
Touchdowns: Davante Adams (12)
Carolina Panthers
Passing: Bryce Young (2,131)
Rushing: Rico Dowdle (871)
Receiving: Tetairoa McMillan (783)
Touchdowns: Rico Dowdle (6)
Coaches:
Los Angeles Rams: Sean McVay (9th season)
Carolina Panthers: Dave Canales (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
