by Rod Pearson
Friday, Dec 05, 2025
Game Time: 4:25 pm ET, Sunday, December 7, 2025
Venue: State Farm Stadium, Glendale, AZ
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Rams -8.5, Cardinals +8.5; Over/Under: 47.5 points
Bet365: Point Spread: Rams -8.5, Cardinals +8.5; Over/Under: 47.5 points
BetMGM: Point Spread: Rams -8, Cardinals +8; Over/Under: 47.5 points
Season Record
Los Angeles Rams: 9-3 (1st place, NFC West)
Arizona Cardinals: 3-9 (4th place, NFC West)
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Recent Form
Los Angeles Rams: lost their last game on the road against the Carolina Panthers 31-28.
Arizona Cardinals: lost their last game on the road against the Tampa Bay Buccaneers 20-17.
Los Angeles Rams vs Arizona Cardinals Preview and Analysis
The Rams are entering this game with a 9-3 record overall and they have a 2-1 record in their divisional games too. They are 5-1 in their home games, 3-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Carolina Panthers 31-28. Matthew Stafford was the starting QB and he completed 18/28 passes for 243 passing yards, 2 touchdowns, and 2 interceptions. Blake Corum led the team in rushing yards with 81 and 1 TD. Xavier Smith led the receivers with 82 receiving yards on 3 receptions. Kamren Kinchens led the defense in that game with 6 solo tackles and 0 assisted tackles while Byron Young and Braden Fiske each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Cardinals are entering this game with a 3-9 record overall and they have a 0-4 record in their divisional games too. They are 1-5 in their home games, 2-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Tampa Bay Buccaneers 20-17. Jacoby Brissett was the starting QB and he completed 29/40 passes for 301 passing yards, 2 touchdowns, and 1 interception. Zonovan Knight led the team in rushing yards with 62. Trey McBride led the receivers with 82 receiving yards on 8 receptions and 1 TD. Akeem Davis-Gaither led the defense in that game with 4 solo tackles and 6 assisted tackles while Josh Sweat led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.
Rams vs Cardinals Prediction
The current betting odds have the Rams listed as an 8.5 point favorite in this game according to Draftkings Sportsbook. The Rams have looked great in their games this season with their 9-3 record overall which has them right at the top of the NFC West with one of the best records in the entire NFL. They have been a good road team too with their 3-2 road record this season. Meanwhile, the Cardinals have looked terrible in their games this season with their 3-9 record overall which has them right at the bottom of the NFC West and eliminated from playoff contention. They have also looked terrible on their home field this year with their 1-5 home record. The Cardinals are off a 20-17 loss to the Buccaneers in their last one and they were able to make that a close game in the end, but they were never really in that one as they were trailing the whole time. They haven't looked great lately either as they have been getting blown out in a lot of their games. The Rams have been rolling lately and are starting to look like one of the best teams in the NFL, but they are off a loss to the Panthers in their last one. They lost 31-28 and Stafford looked terrible with a lot of turnovers, but they will be looking to bounce back in this one and Stafford isn't going to play that bad in back-to-back weeks. Look for the Rams to bounce back with a statement win against a hopeless Cardinals team that has been a disaster all season. The best way to place a bet here is on the Rams to cover the spread in this game.
Rams Cardinals Prediction: Our NFL Pick for Sunday, December 7, 2025 (4:25 pm ET start time) is Rams 35 Cardinals 13.
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NFL Betting Trends
Los Angeles Rams: 29-18 ATS in all games. 9-2 ATS as a road favorite. 6-1 ATS after allowing 30 points or more last game. 7-4 OVER as a road favorite. 9-5 OVER in games played on a grass field.
Arizona Cardinals: 4-7 ATS in a home game where the total is greater than or equal to 45.5. 6-10 ATS versus division opponents. 16-6 OVER in home games. 14-5 OVER in a home game where the total is between 42.5 and 49 points.
Key Injuries
Los Angeles Rams: D. Adams (WR) Injured - Hamstring. D. Williams (CB) Injured - Tibia. P. Ford (DL) Injured - Calf. T. Atwell (WR) Injured - Hamstring. K. Williams (RB) Injured - Ankle. B. Young (LB) Injured - Knee. O. Speights (LB) Injured - Ankle. K. Kinchens (S) Injured - Shoulder.
Arizona Cardinals: X. Weaver (WR) Injured - Hamstring. K. Beachum (OG) Injured - Groin. J. Sweat (LB) Injured - Rest. L. Collier (DL) Injured - Knee. G. Dortch (WR) Injured - Chest. E. Demercado (RB) Injured - Ankle. M. Melton (CB) Injured - Heel. C. Jones (OG) Injured - Knee. M. Harrison Jr. (WR) Injured - Heel. D. Taylor-Demerson (S) Injured - Ankle. T. Benson (RB) Injured - Knee. W. Nolen III (DL) Injured - Knee.
Notable Quotes
“They made the plays to be able to win the football game. The things that we’ve been doing at a high clip we didn’t do today. We gave ourselves chances to get back in it and retake leads. And turnovers and some of the fourth down conversions they were able to convert was a difference.” - Sean McVay after his team’s loss against the Panthers in their last game.
“We’ve figured out how to compete, we’ve got to figure out how to win.” - Jonathan Gannon after his team’s loss against the Buccaneers in their last game.
Starting Lineups
Los Angeles Rams
WR Adams, Davante
WR Nacua, Puka
WR Smith, Xavier
TE Parkinson, Colby
QB Stafford, Matthew
RB Williams, Kyren
Arizona Cardinals
WR Weaver, Xavier
WR Wilson, Michael
WR Dortch, Greg
TE McBride, Trey
QB Brissett, Jacoby
RB Knight, Bam
Statistical Leaders
Los Angeles Rams
Passing: Matthew Stafford (3,073)
Rushing: Kyren Williams (868)
Receiving: Puka Nacua (1,019)
Touchdowns: Davante Adams (14)
Arizona Cardinals
Passing: Jacoby Brissett (2,188)
Rushing: Bam Knight (255)
Receiving: Trey McBride (879)
Touchdowns: Trey McBride (8)
Coaches:
Los Angeles Rams: Sean McVay (9th season)
Arizona Cardinals: Jonathan Gannon (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
