Los Angeles Lakers vs Los Angeles Clippers Prediction, Preview and Odds - 01/22/2026

Game Time: 10:00 pm ET, Thursday, January 22, 2026

Venue:  Intuit Dome, Inglewood, CA

Where to Watch:  Prime Video

DraftKings:  Point Spread:  Lakers +1.5, Clippers -1.5; Over/Under:  224.5 points

Bet365:  Point Spread:  Lakers +1.5, Clippers -1.5; Over/Under:  224.5 points

BetMGM:  Point Spread:  Lakers -1.5, Clippers +1.5; Over/Under:  224.5 points

Los Angeles Lakers:  26-16 (1st place, Pacific Division)

Los Angeles Clippers:  19-24 (4th place, Pacific Division)

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Los Angeles Lakers:  5-5 last 10

Los Angeles Clippers:  7-3 last 10

The Lakers are entering this game with a 26-16 record overall this season and they are 14-8 in their road games this season where they will be in this game. They are entering this game on a 2 game winning streak with wins coming against the Toronto Raptors and the Denver Nuggets. Luka Dončić led the team in points in that game with 38 while LeBron James was next on the team with 19 points. Luka Dončić led the team in assists in that game with 10 while Luka Dončić led the team in rebounds with 13. They were 50.6% from the field, 40% from 3-point range, and 65.6% from the free throw line with their shots in that game. Their offense is averaging 116.3 PPG and their defense is allowing their opponents to average 116.5 PPG against them. The Lakers have an ATS record of 23-19 this season and their O/U record is 25-17.

The Clippers are entering this game with a 19-24 record overall this season and they are 11-9 in their home games this season where they will be in this game. They are entering this game off a loss against the Chicago Bulls. James Harden led the team in points in that game with 24 while John Collins was next on the team with 23 points. James Harden and Kris Dunn each led the team in assists in that game with 6 while Ivica Zubac led the team in rebounds with 11. They were 46.7% from the field, 33.3% from 3-point range, and 82.4% from the free throw line with their shots in that game. Their offense is averaging 112.3 PPG and their defense is allowing their opponents to average 113.8 PPG against them. The Clippers have an ATS record of 20-23 this season and their O/U record is 21-22.

The current betting odds have the Lakers listed as a 1.5 point underdog in this game according to Draftkings Sportsbook. The Lakers have looked good in their games this season with their 26-16 record overall which has them in the top half of the West. They have been a good road team this year too with their 14-8 road record. Meanwhile, the Clippers haven't looked good in their games this season with their 19-24 record overall which has them in the bottom half of the West. They have looked better on their home court though with their 11-9 home record this year. The Clippers were one of the worst teams in the West just a few weeks ago, but they got their act together and have been rolling lately. They are 7-3 in their last 10 games and have been red hot, but now they are off a loss to the Bulls in their last one and they lost a lot of their momentum with that loss. They are missing a really important player in their lineup too and that is going to be a huge blow to this team going forward. The Lakers haven't looked that great lately as they are 5-5 in their last 10 games, but they are off a road win over the Nuggets in their last one and have some momentum on their side now with 2 wins in a row. They aren't at full strength either, but they have been healthy enough with a lot of their key players playing, and they have been able to keep themselves near the top of the West all season. The Lakers have improved a lot from last season and are a much better team in road games this season, they will bring their best effort here for their local rival and beat up on them while they are banged up. The best way to place a bet here is on the Lakers to cover the spread in this game. 

Lakers Clippers Prediction:  Our NBA Pick for Thursday, January 22, 2026 (10:00 pm ET start time) is Lakers 110 Clippers 102.

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Los Angeles Lakers: 20-31 ATS off a road win. 16-26 ATS on the road when playing against a team with a losing record. 33-24 UNDER revenging a same season loss vs opponent. 

Los Angeles Clippers: 4-0 ATS after a blowout loss by 20 points or more. 16-10 ATS at home when playing against a good team (Win Pct. 60% to 70%). 6-0 UNDER after allowing 135 points or more. 

Los Angeles Lakers:  D. Ayton (C) Day To Day - Eye. A. Reaves (SG) Out - Calf. A. Thiero (SF) Out - Knee.

Los Angeles Clippers:  K. Leonard (SF) Day To Day - Ankle. B. Bogdanovic (SG) Out - Hamstring. D. Jones Jr. (SF) Out - Knee. B. Beal (SG) Out For Season - Hip.

“They were playing great basketball, Murray playing at an All-Star level, they have a lot of great players. We just stayed together and fought this out.” - Luka Doncic after their win against the Nuggets in their game on Tuesday.

"Of course, you know, the trip we had, going 2-1 was a good trip for us but I thought this game on a back to back really caught up to us. Guys were tired, were slow. We're already slow, but slower." - Ty Lue after his team’s loss against the Bulls in their game on Tuesday.

PG Luka Doncic

SG Marcus Smart

SF Rui Hachimura

PF LeBron James

C Deandre Ayton

PG James Harden

SG Kris Dunn

SF Kobe Sanders

PF John Collins 

C Ivica Zubac

PPG: Luka Doncic (33.5)

APG: Luka Doncic (8.7)

Reb/G: Deandre Ayton (8.8)

PPG: Kawhi Leonard (28.2)

APG: James Harden (8)

Reb/G: Ivica Zubac (10.8)

Coaches:

Los Angeles Lakers: JJ Redick (2nd season)

Los Angeles Clippers: Tyronn Lue (6th season)