by Rod Pearson
Thursday, May 21, 2026
Game Time: 7:40 pm ET, Friday, May 22, 2026
Venue: American Family Field, Milwaukee, WI
Where to Watch: MLB TV
Opening Odds at USA Sportsbooks
DraftKings: Moneyline odds: Dodgers -115, Brewers -105; Over/Under: 8.5 runs
Bet365: Moneyline odds: Dodgers -115, Brewers -105; Over/Under: 8.5 runs
BetMGM: Moneyline odds: Dodgers -115, Brewers -105; Over/Under: 8.5 runs
Season Record
Los Angeles Dodgers: 31-19 (1st place, NL West)
Milwaukee Brewers: 29-18 (1st place, NL Central)
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Recent Form
Los Angeles Dodgers: 7-3 last 10
Milwaukee Brewers: 8-2 last 10
Los Angeles Dodgers vs Milwaukee Brewers Preview and Analysis
The Dodgers are entering this series off a win and won their 3-game series against the San Diego Padres 2-1 in their last series. They enter this game with a 31-19 record overall and have a road record of 16-9. This is the series opener of a 3-game series with the Brewers on Friday and they have Thursday off as a day of rest. Their offense ranks 1st in the MLB with a .776 OPS. Shohei Ohtani was their starting pitcher on Wednesday while Justin Wrobleski is making his start in this game on Friday. He is 6-1 with a 2.49 ERA this season. His team won 6 of their last 7 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 1 BB with 5 SO on 7 hits through 6 IP against the Los Angeles Angels.
The Brewers are entering this series off a win and completed the sweep in their 3-game series against the Chicago Cubs 3-0 in their last series. They enter this game with a 29-18 record overall and have a home record of 15-9. This is the 1st game of a 3-game series with the Dodgers on Friday and they have Thursday off as a day of rest. Their offense ranks 29th in the MLB with a .658 OPS. Kyle Harrison was their starting pitcher on Wednesday while Logan Henderson is making his start in this game on Friday. He is 1-1 with a 3.50 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 walk with 7 strikeouts on 6 hits through 5 innings pitched against the Minnesota Twins.
Dodgers vs Brewers Prediction
The current betting odds have the Dodgers listed as a slight favorite in this game according to Draftkings Sportsbook. The Dodgers have looked great in their games this season with their 31-19 record overall which has them right at the top of the NL West with one of the best records in MLB. They have been a good road team too with their 16-9 road record this year. Meanwhile, the Brewers have looked great in their games this season with their 29-18 record overall which has them right at the top of the NL Central. They have looked good in their own ballpark too with their 15-9 home record this season. The Brewers are 8-2 in their last 10 games and they have been rolling lately, but the Dodgers are 7-3 in their last 10 games and still have one of the best rosters in baseball. They are going to have the edge in this game too with the better pitching matchup and the Dodgers also have one of the best offenses in MLB while the Brewers have one of the worst. The Dodgers are going with Wrobleski in this one and he has looked great this year. He is 6-1 with a 2.49 ERA this season and the team has had a ton of success with him. His team has won 6 of their last 7 games with him starting and he is off a start in which he gave up 2 earned runs, something that has been a common theme for him. The Brewers are going with Henderson in this one and he hasn't looked bad this year. He is 1-1 with a 3.50 ERA, but he has been a bit up and down this year. He only gave up 1 earned run in his last start and the team has won 2 games in a row now with him starting, but the offense is still going to be an issue for them in this one. The Brewers are also off a series sweep of the Cubs who are one of the threats in their own division, so they are due for a let down here against one of the best in the league. Look for the Dodgers to continue rolling with that stronger offense. The best way to place a bet here is on the Dodgers to win this game.
Dodgers Brewers Prediction: Our MLB Pick for Friday, May 22, 2026 (7:40 pm ET start time) is Dodgers 6 Brewers 3.
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MLB Betting Trends
Los Angeles Dodgers: 39-37 (-18.7 units) on the moneyline against NL Central opponents. 246-161 (-13.8 units) on the moneyline in all games. 220-129 (-10.2 units) on the moneyline as a favorite of -110 or higher. 58-39 UNDER on the road with a money line of -100 to -150.
Milwaukee Brewers: 223-161 (+43.1 units) on the moneyline in all games. 117-76 (+17.3 units) on the moneyline in home games. 75-65 (+26.2 units) on the moneyline as an underdog of +100 or higher. 18-9 UNDER after shutting out their opponent.
Key Injuries
Los Angeles Dodgers: B. Casparius (RP) Sixty Day IL - Shoulder. B. Graterol (RP) Sixty Day IL - Shoulder. J. Dreyer (RP) Fifteen Day IL - Shoulder. B. Snell (SP) Fifteen Day IL - Elbow. E. Diaz (RP) Sixty Day IL - Elbow. B. Stewart (RP) Fifteen Day IL - Foot. T. Glasnow (SP) Fifteen Day IL - Back. L. Knack (SP) Sixty Day IL - Undisclosed. J. Cousins (RP) Sixty Day IL - Elbow. G. Stone (SP) Sixty Day IL - Shoulder. B. Miller (SP) Sixty Day IL - Shoulder. T. Edman (2B) Sixty Day IL - Ankle. E. Hernandez (1B) Sixty Day IL - Elbow. E. Phillips (RP) Sixty Day IL - Elbow.
Milwaukee Brewers: G. Mitchell (CF) Day To Day - Back. B. Lockridge (LF) Ten Day IL - Knee. B. Woodruff (SP) Fifteen Day IL - Arm. A. Zerpa (RP) Fifteen Day IL - Forearm. R. Zastryzny (RP) Sixty Day IL - Shoulder. J. Koenig (RP) Fifteen Day IL - Elbow. Q. Priester (SP) Fifteen Day IL - Wrist. A. Baddoo (LF) Sixty Day IL - Quadriceps.
Notable Quotes
“For Shohei, you’re just constantly trying to manage his workload, his health, the surgeries and all that stuff.” - Dave Roberts on managing the workload for Shohei Ohtani.
"We have a very young club. But yeah, I think it gives you a little confidence. I trust these guys. They have high expectations of themselves, and we have high standards.” - Pat Murphy after his team’s sweep of the Cubs in their last series.
Starting Lineups
Los Angeles Dodgers
Shohei Ohtani (L) P
Mookie Betts (R) SS
Freddie Freeman (L) 1B
Kyle Tucker (L) RF
Andy Pages (R) CF
Max Muncy (L) 3B
Will Smith (R) C
Teoscar Hernández (R) LF
Hyeseong Kim (L) 2B
Milwaukee Brewers
Jackson Chourio (R) LF
Brice Turang (L) 2B
William Contreras (R) C
Christian Yelich (L) DH
Garrett Mitchell (L) CF
Jake Bauers (L) 1B
Sal Frelick (L) RF
Joey Ortiz (R) SS
David Hamilton (L) 3B
Statistical Leaders
Los Angeles Dodgers
Batting Average: Ryan Ward (.333)
Hits: Andy Pages (53)
Home Runs: Max Muncy (12)
RBI: Andy Pages (42)
Stolen Bases: Andy Pages (6)
Wins: Justin Wrobleski (6)
Saves: Edwin Díaz (4)
ERA: Charlie Barnes (0.00)
Milwaukee Brewers
Batting Average: Tyler Black (.333)
Hits: William Contreras (53)
Home Runs: Jake Bauers (7)
RBI: Jake Bauers (29)
Stolen Bases: David Hamilton (10)
Wins: Aaron Ashby (8)
Saves: Trevor Megill (5)
ERA: Jared Koenig (0.00)
Managers:
Los Angeles Dodgers: Dave Roberts (11th season)
Milwaukee Brewers: Pat Murphy (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
