by Rod Pearson
Tuesday, Oct 28, 2025
Game Time: 1:00 pm ET, Sunday, November 2, 2025
Venue: Nissan Stadium, Nashville, TN
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chargers -10, Titans +10; Over/Under: 43.5 points
Bet365: Point Spread: Chargers -10, Titans +10; Over/Under: 43.5 points
BetMGM: Point Spread: Chargers -10, Titans +10; Over/Under: 43.5 points
Season Record
Los Angeles Chargers: 5-3 (2nd place, AFC West)
Tennessee Titans: 1-7 (4th place, AFC South)
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Los Angeles Chargers: won their last game at home against the Minnesota Vikings 37-10.
Tennessee Titans: lost their last game on the road against the Indianapolis Colts 38-14.
Los Angeles Chargers vs Tennessee Titans Preview and Analysis
The Chargers are entering this game with a 5-3 record overall and they have a 3-0 record in their divisional games too. They are 2-2 in their home games, 2-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Minnesota Vikings 37-10. Justin Herbert was the starting QB and he completed 18/25 passes for 227 passing yards, 3 touchdowns, and 1 interception. Kimani Vidal led the team in rushing yards with 117 and 1 TD. Ladd McConkey led the receivers with 88 receiving yards on 6 receptions and 1 TD. Benjamin St-Juste led the defense in that game with 7 solo tackles and 0 assisted tackles while Justin Eboigbe led the defense in sacks with 2. R.J. Mickens came away with the only interception for them in that one.
The Titans are entering this game with a 1-7 record overall and they have a 0-3 record in their divisional games too. They are 0-3 in their home games, 1-4 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Indianapolis Colts 38-14. Cameron Ward was the starting QB and he completed 22/38 passes for 259 passing yards, 1 touchdown, and 1 interception. Tyjae Spears led the team in rushing yards with 59 and 1 TD. Chimere Dike led the receivers with 93 receiving yards on 7 receptions. Darrell Baker Jr., Cedric Gray, and Amani Hooker each led the defense in that game with 4 solo tackles and 1 assisted tackle while Roger McCreary, Dre'Mont Jones, and T'Vondre Sweat each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Chargers vs Titans Prediction
The current betting odds have the Chargers listed as a 10 point favorite in this game according to Draftkings Sportsbook. The Chargers have looked good in their games this season with their 5-3 record overall which has them right near the top of the AFC West. They have cooled off from their hot start to the season, struggling a lot over the last few weeks, but now they are off a 37-10 win over the Vikings in their last one and they are going to have some momentum from that win. That game was also on Thursday so they have some extra rest for this game. Meanwhile, the Titans have looked terrible in their games this season with their 1-7 record overall which has them right at the bottom of the AFC South with the worst record in the entire NFL. They are off a 38-14 loss to the Colts in their last one and they have been getting blown out in most of their games this season. They have also fired their head coach already so they are a disaster right now and the schedule isn't getting any easier either. Cam Ward is still trying to find his way in this offense. There has been some good plays, but there has also been a lot of bad plays and the offense is going to struggle with this Chargers defense getting healthier. The Titans defense hasn't been terrible this year, but they can only hold on for so long in these games where the offense isn't doing anything. They won't be able to keep this Chargers offense at bay and the Chargers will be able to pull away throughout the game, just like most of the Titans' opponents tend to do. The best way to place a bet here is on the Chargers to cover the spread in this game.
Chargers Titans Prediction: Our NFL Pick for Sunday, November 2, 2025 (1:00 pm ET start time) is Chargers 38 Titans 13.
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NFL Betting Trends
Los Angeles Chargers: 8-3 ATS as a favorite of 3.5 to 9.5 points. 7-3 ATS after allowing 14 points or less last game. 6-0 ATS vs. poor passing teams averaging 5.7 or less passing yards/att. 4-0 OVER against AFC South division opponents. 4-1 OVER versus poor rushing teams - averaging 90 rushing yards/game or less.
Tennessee Titans: 11-30 ATS in all games. 4-17 ATS as an underdog of 3.5 to 9.5 points. 7-23 ATS against conference opponents. 5-15 ATS after playing their last game on the road. 8-4 OVER as a home underdog. 11-3 OVER after scoring 14 points or less last game.
Key Injuries
Los Angeles Chargers: T. Jefferson (S) Injured - Hamstring. D. James Jr. (S) Injured - Ankle. W. Dissly (TE) Injured - Illness. M. Becton (OG) Injured - Knee. A. Deculus (OT) Injured - Ankle. J. Salyer (OG) Injured - Knee. H. Haskins (RB) Injured - Hamstring. K. Williamson (S) Injured - Achilles. D. Leonard (CB) Injured - Knee. T. Still (CB) Injured - Knee. L. McConkey (WR) Injured - Calf.
Tennessee Titans: K. Zeitler (OG) Injured - NIR-Rest. X. Woods (S) Injured - Hamstring. C. Ridley (WR) Injured - Hamstring. A. Key (LB) Injured - Quadricep. J. Lynch (DL) Injured - Shoulder. D. Baker Jr. (CB) Injured - Concussion. T. Pollard (RB) Injured - Neck. J. Simmons (DL) Injured - Hamstring. B. Hance (OG) Injured - Shoulder. D. Moore Jr. (OT) Injured - Shoulder. C. Okonkwo (TE) Injured - Foot. B. Oliver (WR) Injured - Knee.
Notable Quotes
“The team really responded. They went back to work after Sunday and they set their minds to it that they weren’t going to be denied.” - Jim Harbaugh after his team’s win against the Vikings in their last game.
“It stinks, losing. It's frustrating for everybody when you're not winning football games. We've got to find a way to win one of these football games. Each week it's tougher to swallow the pill.” - Mike McCoy after his team’s loss against the Colts in their last game.
Starting Lineups
Los Angeles Chargers
WR Johnston, Quentin
WR Allen, Keenan
WR McConkey, Ladd
TE Gadsden, Oronde
QB Herbert, Justin
RB Vidal, Kimani
FB Matlock, Scott
Tennessee Titans
WR Ayomanor, Elic
WR Jefferson, Van
WR Dike, Chimere
TE Okonkwo, Chig
QB Ward, Cam
RB Pollard, Tony
Statistical Leaders
Los Angeles Chargers
Passing: Justin Herbert (2,140)
Rushing: Omarion Hampton (314)
Receiving: Keenan Allen (479)
Touchdowns: Quentin Johnston (5)
Tennessee Titans
Passing: Cam Ward (1,615)
Rushing: Tony Pollard (424)
Receiving: Calvin Ridley (290)
Touchdowns: Elic Ayomanor (2)
Coaches:
Los Angeles Chargers: Jim Harbaugh (2nd season)
Tennessee Titans: Mike McCoy (Interim)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
