by Rod Pearson
Wednesday, Dec 10, 2025
Game Time: 1:00 pm ET, Sunday, December 14, 2025
Venue: GEHA Field at Arrowhead Stadium, Kansas City, MO
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chargers +4.5, Chiefs -4.5; Over/Under: 41.5 points
Bet365: Point Spread: Chargers +4.5, Chiefs -4.5; Over/Under: 41.5 points
BetMGM: Point Spread: Chargers +4.5, Chiefs -4.5; Over/Under: 41.5 points
Season Record
Los Angeles Chargers: 9-4 (2nd place, AFC West)
Kansas City Chiefs: 6-7 (3rd place, AFC West)
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Recent Form
Los Angeles Chargers: won their last game at home against the Philadelphia Eagles 22-19 in overtime.
Kansas City Chiefs: lost their last game at home against the Houston Texans 20-10.
Los Angeles Chargers vs Kansas City Chiefs Preview and Analysis
The Chargers are entering this game with a 9-4 record overall and they have a 4-0 record in their divisional games too. They are 5-2 in their home games, 3-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Philadelphia Eagles 22-19 in OT. Justin Herbert was the starting QB and he completed 12/26 passes for 139 passing yards, 1 touchdown, and 1 interception. Justin Herbert led the team in rushing yards with 66. Kimani Vidal led the receivers with 60 receiving yards on 1 reception. Daiyan Henley led the defense in that game with 6 solo tackles and 1 assisted tackle while Odafe Oweh led the defense in sacks with 1. Tony Jefferson, Cam Hart, Da'Shawn Hand, and Donte Jackson each came away with 1 interception for them in that one.
The Chiefs are entering this game with a 6-7 record overall and they have a 1-2 record in their divisional games too. They are 5-2 in their home games, 1-4 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Houston Texans 20-10. Patrick Mahomes was the starting QB and he completed 14/33 passes for 160 passing yards, 0 touchdowns, and 3 interceptions. Patrick Mahomes led the team in rushing yards with 59. Xavier Worthy led the receivers with 55 receiving yards on 3 receptions. Nick Bolton led the defense in that game with 6 solo tackles and 6 assisted tackles while George Karlaftis and Chris Jones each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Chargers vs Chiefs Prediction
The current betting odds have the Chargers listed as a 4.5 point underdog in this game according to Draftkings Sportsbook. The Chargers have looked really good in their games this season with their 9-4 record overall which has them right near the top of the AFC West. They have been a good road team too with their 3-2 road record this year. Meanwhile, the Chiefs haven't looked good in their games this season with their 6-7 record overall which has them right near the bottom of the AFC West. They have looked a lot better on their home field though with their 5-2 home record this season. The Chiefs haven't looked good lately though, coming off a 20-10 loss to the Texans in their last one, and they are starting to look like a team that is going to miss the playoffs. Even when they have been winning games lately, they have been barely getting by in those wins. The Chargers are off a 22-19 win over the Eagles in their last one and they have been dealing with a lot of injuries this year, but they continue to find ways to win games. They have been rolling in their games lately too, and they have already beaten the Chiefs this season so this isn't a team they are going to be scared to play, especially with the way the Chiefs have looked lately. Even in a loss, the Chargers will keep this a tighter game. The best way to place a bet here is on the Chargers to cover the spread in this game.
Chargers Chiefs Prediction: Our NFL Pick for Sunday, December 14, 2025 (1:00 pm ET start time) is Chargers 20 Chiefs 17.
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NFL Betting Trends
Los Angeles Chargers: 12-5 ATS in all games where the total is between 35.5 and 42 points. 9-5 ATS versus division opponents. 21-14 ATS after playing on Monday night football. 5-1 UNDER as a road underdog. 5-1 UNDER after a win by 6 or less points.
Kansas City Chiefs: 2-6 ATS after 3 or more consecutive losses against the spread. 7-15 ATS as a favorite of 3.5 to 9.5 points. 5-9 ATS versus division opponents. 12-4 UNDER as a home favorite of 7 points or less. 9-2 UNDER off an upset loss as a favorite.
Key Injuries
Los Angeles Chargers: K. Allen (WR) Injured - Rest. K. Mack (LB) Injured - Rest. W. Dissly (TE) Injured - Shoulder. T. Dye (LB) Injured - Hip. J. Herbert (QB) Injured - Hand. E. Molden (CB) Injured - Hamstring. D. Davis (WR) Injured - Ankle. T. Pipkins III (OG) Injured - Ankle. L. McConkey (WR) Injured - Foot.
Kansas City Chiefs: N. Bolton (LB) Injured - Illness. P. Mahomes (QB) Injured - Knee. J. Smith-Schuster (WR) Injured - Rib. J. Taylor (OT) Injured - Triceps. N. Gray (TE) Injured - Shoulder. H. Brown (WR) Injured - NIR-Personal. T. Smith (OG) Injured - Ankle. N. Remigio (WR) Injured - Concussion. T. McDuffie (CB) Injured - Knee. B. Cook (S) Injured - Ankle. R. Rice (WR) Injured - Hamstring. W. Morris (OG) Injured - Knee.
Notable Quotes
"What a team we have, they refuse to lose.” - Jim Harbaugh after his team’s win against the Eagles in their last game.
“Listen, they battled. Some of the guys in there hadn't practiced much.” - Andy Reid after his team’s loss against the Texans in their last game.
Starting Lineups
Los Angeles Chargers
WR Johnston, Quentin
WR Allen, Keenan
WR McConkey, Ladd
TE Gadsden, Oronde
QB Herbert, Justin
RB Hampton, Omarion
FB Matlock, Scott
Kansas City Chiefs
WR Brown, Hollywood
WR Worthy, Xavier
WR Rice, Rashee
TE Kelce, Travis
QB Mahomes, Patrick
RB Hunt, Kareem
Statistical Leaders
Los Angeles Chargers
Passing: Justin Herbert (2,981)
Rushing: Kimani Vidal (587)
Receiving: Ladd McConkey (695)
Touchdowns: Quentin Johnston (7)
Kansas City Chiefs
Passing: Patrick Mahomes (3,398)
Rushing: Kareem Hunt (545)
Receiving: Travis Kelce (722)
Touchdowns: Kareem Hunt (9)
Coaches:
Los Angeles Chargers: Jim Harbaugh (2nd season)
Kansas City Chiefs: Andy Reid (13th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
