by Rod Pearson
Tuesday, Nov 11, 2025
Game Time: 1:00 pm ET, Sunday, November 16, 2025
Venue: EverBank Stadium, Jacksonville, FL
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chargers -3, Jaguars +3; Over/Under: 43.5 points
Bet365: Point Spread: Chargers -3, Jaguars +3; Over/Under: 44 points
BetMGM: Point Spread: Chargers -3, Jaguars +3; Over/Under: 44 points
Season Record
Los Angeles Chargers: 7-3 (2nd place, AFC West)
Jacksonville Jaguars: 5-4 (2nd place, AFC South)
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Los Angeles Chargers: won their last game at home against the Pittsburgh Steelers 25-10.
Jacksonville Jaguars: lost their last game on the road against the Houston Texans 36-29.
Los Angeles Chargers vs Jacksonville Jaguars Preview and Analysis
The Chargers are entering this game with a 7-3 record overall and they have a 3-0 record in their divisional games too. They are 3-2 in their home games, 3-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Pittsburgh Steelers 25-10. Justin Herbert was the starting QB and he completed 20/33 passes for 220 passing yards, 1 touchdown, and 0 interceptions. Kimani Vidal led the team in rushing yards with 95 and 1 TD. Ladd McConkey led the receivers with 107 receiving yards on 4 receptions and 1 TD. Daiyan Henley led the defense in that game with 5 solo tackles and 1 assisted tackle while Tuli Tuipulotu, Bud Dupree, and Khalil Mack each led the defense in sacks with 1. Donte Jackson and R.J. Mickens each came away with 1 interception for them in that one.
The Jaguars are entering this game with a 5-4 record overall and they have a 1-1 record in their divisional games too. They are 3-1 in their home games, 2-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Houston Texans 36-29. Trevor Lawrence was the starting QB and he completed 13/23 passes for 158 passing yards, 1 touchdown, and 1 interception. Travis Etienne Jr. led the team in rushing yards with 58 and 1 TD. Jakobi Meyers led the receivers with 41 receiving yards on 3 receptions. Greg Newsome II led the defense in that game with 4 solo tackles and 3 assisted tackles while Antonio Johnson and Arik Armstead each led the defense in sacks with 1. Jarrian Jones came away with the only interception for them in that one.
Chargers vs Jaguars Prediction
The current betting odds have the Chargers listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Chargers have looked good in their games this season with their 7-3 record overall which has them right near the top of the AFC West. They are off a 25-10 win over the Steelers in their last one and they continue to find ways to win games, even with all of their injuries. Meanwhile, the Jaguars have looked good in their games this season with their 5-4 record overall which has them right near the top of the AFC South. The Jaguars got off to a hot start to the season, but they haven't looked that good lately. They have been falling apart since pulling off the upset win over the Chiefs on MNF and now they are off a terrible 36-29 loss to the Texans in their last one, blowing a 29-10 lead going into the 4th quarter. They have also been dealing with a lot of injuries as they have lost their 2 star WR's. Their defense hasn't looked great lately either and that is going to be an issue here with Herbert playing so well in this Chargers offense. The Chargers defense has also looked a lot better lately as they have been getting healthier. The Jags were a nice story to start the season, but they have regressed back to the mean now while this Chargers team is a true playoff team. The best way to place a bet here is on the Chargers to cover the spread in this game.
Chargers Jaguars Prediction: Our NFL Pick for Sunday, November 16, 2025 (1:00 pm ET start time) is Chargers 31 Jaguars 23.
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NFL Betting Trends
Los Angeles Chargers: 1-4 ATS against AFC South division opponents. 3-6 ATS vs. poor passing defenses - allowing 235 or more passing yards/game. 5-9 ATS versus poor defensive teams - allowing 5.65 yards/play or more. 8-3 UNDER in a road game where the total is between 42.5 and 49 points. 8-2 UNDER vs. poor passing defenses - allowing 235 or more passing yards/game.
Jacksonville Jaguars: 7-4 ATS after allowing 30 points or more last game. 9-4 ATS when playing against a good team (Win Pct. 60% to 75%). 5-2 ATS vs. good passing defenses - allowing 175 or less passing yards/game. 14-6 UNDER in games where the line is +3 to -3. 8-1 UNDER off a road loss.
Key Injuries
Los Angeles Chargers: K. Allen (WR) Injured - Rest. K. Mack (LB) Injured - Rest. B. Hart (OT) Injured - Knee. B. Bozeman (C) Injured - Rest. D. Henley (LB) Injured - Ankle. T. Tart (DL) Injured - Rest. Q. Johnston (WR) Injured - Shin. T. Still (CB) Injured - Knee. L. McConkey (WR) Injured - Ankle. O. Gadsden (TE) Injured - Knee.
Jacksonville Jaguars: J. Lewis (CB) Injured - Neck. D. Gardeck (LB) Injured - Chest. H. Long (TE) Injured - Hip. E. Cleveland (OG) Injured - Knee. R. Hainsey (C) Injured - Groin. P. Mekari (OG) Injured - Knee. G. Newsome II (CB) Injured - Shoulder. B. Strange (TE) Injured - Hip. P. Washington (WR) Injured - Hamstring. A. Harrison (OG) Injured - Knee. B. Thomas Jr. (WR) Injured - Ankle. W. Milum (OG) Injured - Knee. J. Kiser (LB) Injured - Shoulder.
Notable Quotes
“I like wins that are decided by great preparation, great strategy, finesse, but the best to me are the physical ones, won by heart and grit and guts, and that’s what this one was.” - Jim Harbaugh after his team’s win against the Steelers in their last game.
“The reality is we gave up a 19-point lead to lose the game. Part of winning in the National Football League is sustaining a lead. We just needed one stop and didn’t get one. You score 29 and you feel like you’re going to have a chance to go get a win, but we didn’t get it done.” - Liam Coen after his team’s loss against the Texans in their last game.
Starting Lineups
Los Angeles Chargers
WR Johnston, Quentin
WR Allen, Keenan
WR McConkey, Ladd
TE Gadsden, Oronde
QB Herbert, Justin
RB Vidal, Kimani
FB Matlock, Scott
Jacksonville Jaguars
WR Brown, Dyami
WR Washington, Parker
WR Meyers, Jakobi
TE Mundt, Johnny
QB Lawrence, Trevor
RB Etienne Jr., Travis
Statistical Leaders
Los Angeles Chargers
Passing: Justin Herbert (2,610)
Rushing: Kimani Vidal (404)
Receiving: Ladd McConkey (631)
Touchdowns: Quentin Johnston (6)
Jacksonville Jaguars
Passing: Trevor Lawrence (1,998)
Rushing: Travis Etienne Jr. (656)
Receiving: Brian Thomas Jr. (420)
Touchdowns: Trevor Lawrence (4)
Coaches:
Los Angeles Chargers: Jim Harbaugh (2nd season)
Jacksonville Jaguars: Liam Coen (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
