by Rod Pearson
Friday, Nov 06, 2026
Game Time: 4:25 pm ET, Sunday, November 8, 2026
Venue: Levi's Stadium, Santa Clara, CA
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Raiders +10, 49ers -10; Over/Under: 51.5 points
Bet365: Point Spread: Raiders +10, 49ers -10; Over/Under: 52 points
BetMGM: Point Spread: Raiders +9.5, 49ers -9.5; Over/Under: 52 points
Season Record
Las Vegas Raiders: 4-4 (3rd place, AFC West)
San Francisco 49ers: 6-1 (1st place, NFC West)
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Recent Form
Las Vegas Raiders: won their last game on the road against the New York Jets 38-33.
San Francisco 49ers: lost their last game on the road against the Atlanta Falcons 29-20.
Las Vegas Raiders vs San Francisco 49ers Preview and Analysis
The Raiders are entering this game with a 4-4 record overall and they have a 1-1 record in their divisional games too. They are 1-3 in their home games, 3-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the New York Jets 38-33. Kirk Cousins was the starting QB and he completed 19/26 passes for 247 passing yards, 3 touchdowns, and 0 interceptions. Mike Washington Jr. led the team in rushing yards with 83. Brock Bowers led the receivers with 92 receiving yards on 7 receptions and 2 TDs. Nakobe Dean led the defense in that game with 12 solo tackles while Maxx Crosby and Tim Keenan III each led the defense in sacks with 1. Jeremy Chinn came away with the only interception for them in that one.
The 49ers are entering this game with a 6-1 record overall and they have a 3-0 record in their divisional games too. They are 4-0 in their home games, 1-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Atlanta Falcons 29-20. Brock Purdy was the starting QB and he completed 27/40 passes for 288 passing yards, 1 touchdown, and 2 interceptions. Kaelon Black led the team in rushing yards with 63 and 1 TD. George Kittle led the receivers with 88 receiving yards on 8 receptions. Fred Warner led the defense in that game with 14 solo tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
Raiders vs 49ers Prediction
The current betting odds have the Raiders listed as a 10 point underdog in this game according to Draftkings Sportsbook. The Raiders haven't looked great in their games this season with their 4-4 record overall which has them right near the bottom of the AFC West. They have been a great road team though with their 3-1 road record this year. Meanwhile, the 49ers have looked great in their games this season with their 6-1 record overall which has them right at the top of the NFC West. They have looked great on their home field too with their 4-0 home record this season. The 49ers had a red hot start to the season and they finally took their 1st loss of the year in their last one, losing 29-20 to the Falcons. They will be looking to bounce back in this one and they have a big advantage since they are also coming out of their bye week, but the injuries have also started for the 49ers and they could start to fade a little. Injuries were a big issue for them last season too and this isn't going to be a game against one of the worst teams in the NFL. The Raiders haven't looked nearly as good lately after starting the season 3-0, but they are coming off a 38-33 win over the Jets in their last one and have some momentum back on their side. They do have one of the worst defenses in the NFL and have been giving up a ton of points all year, but they also have a great offense that has been putting up a ton of points too. They have looked a lot better in their road games too and even if this is a game that they can't win against a stronger opponent, they aren't going to go away in this game with that great offense and will be able to keep this game competitive. The best way to place a bet here is on the Raiders to cover the spread in this game.
Raiders 49ers Prediction: Our NFL Pick for Sunday, November 8, 2026 (4:25 pm ET start time) is 49ers 30 Raiders 27.
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NFL Betting Trends
Las Vegas Raiders: 6-1 ATS when playing against a top-level team (Win Pct. > 75%). 4-1 ATS vs. good teams - outscoring opponents by 6+ PPG on the season. 21-14 OVER as an underdog. 16-4 OVER after playing their last game on the road. 10-4 OVER when playing against a team with a winning record.
San Francisco 49ers: 5-10 ATS in a home game where the total is greater than or equal to 45.5. 3-11 ATS vs. good passing teams averaging 7 or more passing yards/att. 5-9 ATS vs. good offensive teams - scoring 24 or more points/game. 8-0 OVER off an upset loss as a favorite. 10-4 OVER vs. good offensive teams - scoring 24 or more points/game.
Key Injuries
Las Vegas Raiders: D. Thornton Jr. (WR) Injured - Back. T. Booker IV (DL) Injured - Ankle. F. Fatukasi (DL) Injured - Shoulder. D. Porter (CB) Injured - Groin. I. Thomas (TE) Injured - Ankle.
San Francisco 49ers: T. Williams (OT) Injured - Rest. C. McCaffrey (RB) Injured - Hamstring. D. Robinson (WR) Injured - Ankle. M. Evans (WR) Injured - Ribs. C. Kirk (WR) Injured - Knee. S. Neal (CB) Injured - Knee. N. Hobbs (CB) Injured - Adductor. L. Gifford (LB) Injured - Groin. N. Bosa (DL) Injured - Knee. G. Wallow (LB) Injured - Hamstring. D. Samuel Sr. (WR) Injured - Hamstring. M. Sigle (S) Injured - Ankle. U. Stout (CB) Injured - Shoulder. M. Williams (DL) Injured - Knee.
Notable Quotes
“Ashton is still going to be a big part of our team. He made a huge catch. He’s going to be a huge part of our run game going forward.” - Klint Kubiak after his team’s win against the Jets in their last game.
“Any time you have four turnovers like that and you get zero, it’s real tough to win. Too sloppy to win.” - Kyle Shanahan after his team’s loss against the Falcons in their last game.
Starting Lineups
Las Vegas Raiders
WR Nailor, Jalen
WR Tucker, Tre
WR Bech, Jack
TE Bowers, Brock
QB Cousins, Kirk
RB Jeanty, Ashton
FB Heyward, Connor
San Francisco 49ers
WR Evans, Mike
WR Samuel Sr, Deebo
WR Watkins, Jordan
TE Kittle, George
QB Purdy, Brock
RB McCaffrey, Christian
FB Juszczyk, Kyle
Statistical Leaders
Las Vegas Raiders
Passing: Kirk Cousins (2,124)
Rushing: Ashton Jeanty (337)
Receiving: Brock Bowers (547)
Touchdowns: Brock Bowers (5)
San Francisco 49ers
Passing: Brock Purdy (1,748)
Rushing: Christian McCaffrey (389)
Receiving: George Kittle (425)
Touchdowns: Christian McCaffrey (8)
Coaches:
Las Vegas Raiders: Klint Kubiak (1st season)
San Francisco 49ers: Kyle Shanahan (10th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
