Kansas Jayhawks vs Duke Blue Devils Prediction, Picks and Game Preview - 11/18/2025

Game Time: 9:00 pm ET, Tuesday, November 18, 2025

Venue:  Madison Square Garden, New York, NY

Where to Watch:  ESPN

DraftKings:  Point Spread:  Kansas +8.5, Duke -8.5; Over/Under:  150.5 points

Bet365:  Point Spread:  Kansas +8.5, Duke -8.5; Over/Under:  150.5 points

BetMGM:  Point Spread:  Kansas +8.5, Duke -8.5; Over/Under:  150.5 points

Kansas Jayhawks:  3-1 (0-0) (16th place, Big 12)

Duke Blue Devils:  4-0 (0-0) (16th place, ACC)

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Kansas Jayhawks:  3-1  last 4

Duke Blue Devils:  4-0  last 4

Kansas is entering this game with a 3-1 record overall, a 0-0 record in conference games, and they are 0-0 in their neutral site games this season where they will be in this game. They are coming off a win against the Princeton Tigers in their last game. Flory Bidunga led the team in points in that game with 25 while Tre White was next on the team with 18. Melvin Council Jr. led the team in assists with 6 in that game while Flory Bidunga led the team in rebounds with 10. They were 47.2% from the field, 23.8% from 3-point range, and 75% from the free throw line with their shooting in that game. Their offense is averaging 80.2 PPG and their defense is allowing their opponents to average 60.2 PPG against them. Kansas has an ATS record of 2-2 this season and their O/U record is 1-3.

Duke is entering this game with a 4-0 record overall, a 0-0 conference record, and they are 1-0 in their neutral site games this season where they will be in this game. They are coming off a win against the Indiana State Sycamores in their last game. Cameron Boozer led the team in points in that game with 35 while Caleb Foster was next on the team with 14. Cameron Boozer led the team in assists with 5 in that game while Cameron Boozer led the team in rebounds with 12. They were 53.5% from the field, 35.7% from 3-point range, and 66.7% from the free throw line with their shooting in that game. Their offense is averaging 96 PPG and their defense is allowing their opponents to average 58.8 PPG against them. Duke has an ATS record of 4-0 this season and their O/U record is 1-3.

The current betting odds have Duke listed as an 8.5 point favorite in this game according to Draftkings Sportsbook. Duke has looked great in their games this season with their 4-0 record overall which has them ranked inside the top 5 at the moment. They have already played a game at a neutral site this year and they won that game. They haven't really been tested yet by another talented team, but Duke has one of the most talented teams in the nation so they can go toe-to-toe with any team. Meanwhile, Kansas has looked good in their games this season with their 3-1 record overall, but that 1 loss has them near the bottom of the Big 12 at the moment. They are ranked inside the top 25 and did lose to another ranked team in a true road game, but they also got blown out by UNC in that game, losing by double digits. Now they are dealing with some injuries too so they aren't going to be at their best here. Kansas doesn't have the talent that Duke has and they aren't going to have the home advantage with this game being at a neutral site. This is a great chance for Duke to earn a ranked win too so look for Duke to bring their best effort. The best way to place a bet here is on Duke to cover the spread in this game. 

Kansas Duke Prediction:  Our NCAAB Pick for Tuesday, November 18, 2025 (9:00 pm ET start time) is Duke 88 Kansas 72.

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Kansas Jayhawks: 4-10 ATS as an underdog. 3-7 ATS after game where they allowed a shooting pct. of 33% or less. 13-21 ATS versus very good teams - outscoring their opponents by 8+ points/game. 13-5 UNDER when playing against a top-level team (Win Pct. > 80%). 22-13 UNDER versus very good teams - outscoring their opponents by 8+ points/game.

Duke Blue Devils: 50-28 ATS in all games. 48-26 ATS as a favorite. 30-14 ATS after a win by 15 points or more. 17-9 ATS when playing against a good team (Win Pct. 60% to 80%). 13-6 UNDER in all neutral court games. 6-2 UNDER as a neutral court favorite of 6.5 to 12 points.

Kansas Jayhawks:  D. Peterson (G) Questionable - Hamstring. C. Allen (G) Out - Redshirt.

Duke Blue Devils:  S. Wilkins (G-F) Out - Redshirt.

"I thought Flory was the best player in the game by far in the first half by far and gave us a lead, because we obviously weren't any good until then. And then, Tre did some good things too. So I would say, of our bright spots, those would probably be the two brightest ones." - Bill Self after his team’s win against Princeton in their last game. 

"We're still working through some of that and that's part of the evolution of where we're going." - Jon Scheyer on his team’s lineup combinations this season.

F. Bidunga 

M. Council 

D. Peterson 

K. Rosario 

T. White

C. Boozer 

I. Evans 

C. Foster 

P. Ngongba 

D. Sarr

PPG: Darryn Peterson (21.5)

APG: Melvin Council Jr. (5.8)

Reb/G: Flory Bidunga (7.8)

PPG: Cameron Boozer (22.5)

APG: Cameron Boozer (4.3)

Reb/G: Cameron Boozer (10.3)

Coaches:

Kansas Jayhawks: Bill Self (23rd season)

Duke Blue Devils: Jon Scheyer (4th season)