Game Time: 1:00 pm ET, Sunday, September 25, 2022
Venue: Lucas Oil Stadium, Indianapolis, IN
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chiefs -7, Colts +7; Over/Under: 49.5 points
Bet365: Point Spread: Chiefs -7, Colts +7; Over/Under: 49.5 points
BetMGM: Point Spread: Chiefs -6.5, Colts +6.5; Over/Under: 49.5 points
Kansas City Chiefs: 2-0 (1st place, AFC West)
Indianapolis Colts: 0-1-1 (3rd place, AFC South)
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Kansas City Chiefs: won their last game at home against the Los Angeles Chargers 27-24.
Indianapolis Colts: lost their last game on the road against the Jacksonville Jaguars 24-0.
Kansas City Chiefs vs Indianapolis Colts Preview and Analysis
The Chiefs are entering this game with a 2-0 record overall and they are playing their 2nd road game of the season here as they are 1-0 in their road games. Their offense is averaging 403.5 YPG and 35.5 PPG while their defense is allowing 341.5 YPG and 22.5 PPG against them. They won their last game at home against the LA Chargers 27-24. Patrick Mahomes II was the starting quarterback in that game and he completed 24/35 passes for 235 yards and 2 touchdowns. Clyde Edwards-Helaire led the team in rushing with 74 yards on 8 rushing attempts. Travis Kelce led the team in receiving with 51 yards on 5 receptions. L'Jarius Sneed led the defense in that game with 7 solo tackles and 1 assisted tackle. Chris Jones led the defense in sacks with 2 while Darius Slay led the defense in interceptions with 2 and Jaylen Watson also came away with 1 interception for them in that one.
The Colts are entering this game with a 0-1-1 record overall and they are playing their 1st home game of the season here. Their offense is averaging 367.5 YPG and 10 PPG while their defense is allowing 315 YPG and 22 PPG against them. They lost their last game on the road against the Jacksonville Jaguars 24-0. Matt Ryan was the starting QB in that game and he completed 16/30 passes for 195 yards and 3 interceptions. Jonathan Taylor led the team in rushing with 54 yards on 9 carries. Ashton Dulin led the team in receiving with 79 yards on 5 catches. Bobby Okereke led the defense in that game with 9 solo tackles and 2 assisted tackles. No one on the defense recorded a sack for them or came away with an interception in that one.
Chiefs vs Colts Prediction
The current betting odds have the Colts listed as a 7 point underdog in this game according to Draftkings Sportsbook. The Colts haven't won a game yet this year while the Chiefs are 2-0 to start their season, but the Colts are coming back home for their home opener here and the team should play a lot better here. They were not able to get much going in Jacksonville last week but they have struggled to win games there for years now. The Chiefs looked very dominant in their 1st game of the season but they barely escaped with a win against the Chargers last week if it wasn't for a pick-6 when the Chargers were in the redzone about to take a lead. The Colts didn't get much going on the ground in their last game but Taylor should have a much better day at home and that will help open up their passing game. This is the 3rd game for Matt Ryan with his new team and he should play a lot better here. The Colts will also be desperate here at home with no wins and even getting shutout in their last game. The Chiefs are going to be playing the Tampa Bay Buccaneers on Sunday night next week too so this is a game they could be overlooking with how bad the Colts have been. The best way to place a bet here is on the Colts to cover the spread in this game.
Chiefs Colts Prediction: Our NFL Pick for Sunday, September 25, 2022 (1:00 pm ET start time) is Chiefs 28 Colts 24.
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NFL Betting Trends
Kansas City Chiefs: 9-15 ATS as a favorite of 3.5 to 9.5 points. 12-18 ATS in all games where the total is greater than or equal to 49.5. 11-6 OVER in road games.
Indianapolis Colts: 16-6 ATS as a home underdog of 3.5 to 7 points. 10-2 ATS off a division game. 9-3 OVER as an underdog.
Kansas City Chiefs: H. Butker (K) day-to-day - Ankle. W. Gay (LB) Elig Week 7 - Suspension. M. Hardman (WR) day-to-day - Ankle.
Indianapolis Colts: S. Leonard (LB) day-to-day - Back. M. Pittman Jr. (WR) day-to-day - Quadricep. A. Pierce (WR) day-to-day - Concussion.
"The thing that I'm most proud of is that we stuck together. Nobody pointed any fingers." - Andy Reid after his team’s win against the Chargers in their last game.
"I don't feel it's a lack of motivation. I just feel it's a lack of we got outcoached and we got outplayed." - Frank Reich after his team’s loss against the Jaguars in their last game.
Kansas City Chiefs
WR Valdes-Scantling, Marquez
WR Hardman, Mecole
WR Smith-Schuster, JuJu
TE KELCE, TRAVIS
QB Mahomes, Patrick
RB Edwards-Helaire, Clyde
FB BURTON, MICHAEL
WR Dulin, Ashton
WR Strachan, Mike
WR Campbell, Parris
TE Alie-Cox, Mo
QB RYAN, MATT
RB Taylor, Jonathan
Kansas City Chiefs
Passing: P. Mahomes (595)
Rushing: C. Edwards-Helaire (116)
Receiving: T. Kelce (172)
Touchdowns: C. Edwards-Helaire (2)
Passing: M. Ryan (547)
Rushing: J. Taylor (215)
Receiving: A. Dulin (125)
Touchdowns: J. Taylor (1)
Kansas City Chiefs: Andy Reid (10th season)
Indianapolis Colts: Frank Reich (5th season)