by Rod Pearson
Friday, Nov 14, 2025
Game Time: 4:25 pm ET, Sunday, November 16, 2025
Venue: Empower Field at Mile High, Denver, CO
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Chiefs -3.5, Broncos +3.5; Over/Under: 44.5 points
Bet365: Point Spread: Chiefs -4, Broncos +4; Over/Under: 45 points
BetMGM: Point Spread: Chiefs -3.5, Broncos +3.5; Over/Under: 45 points
Season Record
Kansas City Chiefs: 5-4 (3rd place, AFC West)
Denver Broncos: 8-2 (1st place, AFC West)
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Recent Form
Kansas City Chiefs: lost their last game on the road against the Buffalo Bills 28-21.
Denver Broncos: won their last game at home against the Las Vegas Raiders 10-7.
Kansas City Chiefs vs Denver Broncos Preview and Analysis
The Chiefs are entering this game with a 5-4 record overall and they have a 1-1 record in their divisional games too. They are 4-1 in their home games, 1-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Buffalo Bills 28-21. Patrick Mahomes was the starting QB and he completed 15/34 passes for 250 passing yards, 0 touchdowns, and 1 interception. Kareem Hunt led the team in rushing yards with 49 and 1 TD. Rashee Rice led the receivers with 80 receiving yards on 4 receptions. Bryan Cook led the defense in that game with 6 solo tackles and 2 assisted tackles while Trent McDuffie and Leo Chenal each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
The Broncos are entering this game with an 8-2 record overall and they have a 1-1 record in their divisional games too. They are 5-0 in their home games, 2-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Las Vegas Raiders 10-7. Bo Nix was the starting QB and he completed 16/28 passes for 150 passing yards, 1 touchdown, and 2 interceptions. J.K. Dobbins led the team in rushing yards with 77. Pat Bryant led the receivers with 43 receiving yards on 1 reception. Talanoa Hufanga led the defense in that game with 5 solo tackles and 4 assisted tackles while Nik Bonitto led the defense in sacks with 1.5. Dondrea Tillman came away with the only interception for them in that one.
Chiefs vs Broncos Prediction
The current betting odds have the Broncos listed as a 3.5 point underdog in this game according to Draftkings Sportsbook. The Broncos have looked great in their games this season with their 8-2 record overall which has them right at the top of the AFC West with one of the best records in the entire NFL. They have been rolling lately with 7 wins in a row now and they are one of the hottest teams in the NFL. Meanwhile, the Chiefs have looked good in their games this season with their 5-4 record overall, but that record has them near the bottom of the AFC West. They had a rough start to the season and have looked better lately, but they still have a lot of ground to make up and they are coming off a loss to the Bills in their last one. They have one of the best defenses in the NFL, but their offense has been an issue this season. They are starting to get healthier on offense now, but Mahomes is coming off a terrible game in Buffalo and has been up and down this season. The Broncos also have a really up and down offense with Bo Nix looking great at times and terrible at others, vut they also have one of the best defenses in the NFL to lean on. That defense has been winning them a lot of games this year when the offense hasn't quite shown up, and they are going to bring their best effort for the Chiefs to pull away more in this division. The Chiefs have the talent to win this game, but that Broncos defense won't make it easy and is going to keep this game within a field goal. The best way to place a bet here is on the Broncos to cover the spread in this game.
Chiefs Broncos Prediction: Our NFL Pick for Sunday, November 16, 2025 (4:25 pm ET start time) is Broncos 20 Chiefs 17.
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NFL Betting Trends
Kansas City Chiefs: 7-4 ATS off 3 or more consecutive unders. 5-2 ATS off an upset loss as a favorite. 4-1 ATS on the road after 1 or more consecutive losses. 31-19 UNDER in all games. 9-2 UNDER as a road favorite of 7 points or less. 11-3 UNDER versus division opponents.
Denver Broncos: 9-14 ATS in all games where the total is between 42.5 and 49 points. 4-7 ATS versus good offensive teams - averaging 5.65 yards/play or more. 1-3 ATS off a home win against a division rival. 8-1 UNDER in a home game where the total is between 42.5 and 49 points. 9-5 UNDER versus division opponents.
Key Injuries
Kansas City Chiefs: X. Worthy (WR) Injured - Ankle. J. Taylor (OT) Injured - Knee. C. Omenihu (DL) Injured - Ankle. T. Smith (OG) Injured - Back. I. Pacheco (RB) Injured - Knee. G. Karlaftis (DL) Injured - Thumb. J. Hicks (CB) Injured - Pectoral. J. Simmons (OT) Injured - NIR - Personal.
Denver Broncos: J. Franklin-Myers (DL) Injured - Back. A. Singleton (LB) Injured - Toe. T. Sherfield Sr. (WR) Injured - Toe. J. Cooper (LB) Injured - Thumb. J. Dobbins (RB) Injured - Foot. G. Wallow (LB) Injured - Hamstring. P. Surtain II (CB) Injured - Pectoral. N. Adkins (TE) Injured - Knee. M. Mims Jr. (WR) Injured - Concussion. J. Elliss (LB) Injured - Hamstring.
Notable Quotes
“Against a team like this, you have to be able to score touchdowns, not field goals.” - Andy Reid after his team’s loss against the Bills in their last game.
“We’ve got to clean up some of the penalties. We’ve got to clean up the execution and that is an ongoing thing that probably never ends.” - Sean Payton after his team’s win against the Raiders in their last game.
Starting Lineups
Kansas City Chiefs
WR Worthy, Xavier
WR Brown, Hollywood
WR Rice, Rashee
TE Kelce, Travis
QB Mahomes, Patrick
RB Hunt, Kareem
Denver Broncos
WR Sutton, Courtland
WR Franklin, Troy
WR Bryant, Pat
TE Trautman, Adam
QB Nix, Bo
RB Harvey, RJ
FB Prentice, Adam
Statistical Leaders
Kansas City Chiefs
Passing: Patrick Mahomes (2,349)
Rushing: Isiah Pacheco (329)
Receiving: Travis Kelce (540)
Touchdowns: Kareem Hunt (6)
Denver Broncos
Passing: Bo Nix (2,126)
Rushing: J.K. Dobbins (772)
Receiving: Courtland Sutton (590)
Touchdowns: RJ Harvey (6)
Coaches:
Kansas City Chiefs: Andy Reid (13th season)
Denver Broncos: Sean Payton (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
