Jacksonville Jaguars vs Indianapolis Colts Prediction, Preview and Odds - 12/28/2025

Game Time: 1:00 pm ET, Sunday, December 28, 2025

Venue:  Lucas Oil Stadium, Indianapolis, IN

Where to Watch:  FOX

DraftKings:  Point Spread:  Jaguars -6.5, Colts +6.5; Over/Under:  47.5 points

Bet365:  Point Spread:  Jaguars -6.5, Colts +6.5; Over/Under:  47.5 points

BetMGM:  Point Spread:  Jaguars -6.5, Colts +6.5; Over/Under:  47.5 points

Jacksonville Jaguars:  11-4 (1st place, AFC South)

Indianapolis Colts:  8-7 (3rd place, AFC South)

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Jacksonville Jaguars:  won their last game on the road against the Denver Broncos 34-20.

Indianapolis Colts:  lost their last game at home against the San Francisco 49ers 48-27.

The Jaguars are entering this game with an 11-4 record overall and they have a 3-1 record in their divisional games too. They are 6-1 in their home games, 5-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Denver Broncos 34-20. Trevor Lawrence was the starting QB and he completed 22/36 passes for 279 passing yards, 3 touchdowns, and 0 interceptions. Travis Etienne Jr. led the team in rushing yards with 50. Parker Washington led the receivers with 145 receiving yards on 6 receptions and 1 TD. Foyesade Oluokun led the defense in that game with 6 solo tackles and 5 assisted tackles while B.J. Green II led the defense in sacks with 1. Jarrian Jones came away with the only interception for them in that one.

 

 

 

The Colts are entering this game with an 8-7 record overall and they have a 2-2 record in their divisional games too. They are 5-2 in their home games, 2-5 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the San Francisco 49ers 48-27. Philip Rivers was the starting QB and he completed 23/35 passes for 277 passing yards, 2 touchdowns, and 1 interception. Jonathan Taylor led the team in rushing yards with 46 and 1 TD. Alec Pierce led the receivers with 86 receiving yards on 4 receptions and 2 TDs. Camryn Bynum led the defense in that game with 5 solo tackles and 2 assisted tackles while Laiatu Latu led the defense in sacks with 1. Camryn Bynum came away with the only interception for them in that one.

The current betting odds have the Jaguars listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Jaguars have looked great in their games this season with their 11-4 record overall which has them right at the top of the AFC South with one of the best records in the entire NFL. They have been a great road team too with their 5-2 road record this year. Meanwhile, the Colts have looked good in their games this season with their 8-7 record overall, but that record has them right near the bottom of the AFC South and fighting for a Wild Card spot. They have looked great on their home field though with their 5-2 home record this season. The Colts had one of the best starts to the season in the entire NFL, but their season has been falling apart lately and now they are at risk of missing the playoffs altogether. They are off a 48-27 loss to the 49ers in their last one and they have lost 5 games in a row now. They have been dealing with injuries too, rolling out Philip Rivers at QB in their last 2 games. Rivers hasn't been terrible considering his age, but the defense was nowhere to be found against the 49ers. Now they have a better Jaguars defense coming into town, and the Jags have a chance to end the Colts season right here. The Jaguars are going to bring their best effort to end a rival's season, and the Jags are still trying to win the division with the Texans right on their tail. The Jaguars have been rolling lately with 6 wins in a row now, and they have a ton of momentum on their side as they are off a 34-20 road win over the Broncos in their last one. This Colts team has been on the brink of death for weeks now so look for the Jaguars to put the final dagger in them. The best way to place a bet here is on the Jaguars to cover the spread in this game. 

Jaguars Colts Prediction:  Our NFL Pick for Sunday, December 28, 2025 (1:00 pm ET start time) is Jaguars 34 Colts 19.

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Jacksonville Jaguars: 28-19 ATS in all games. 11-4 ATS versus division opponents. 9-4 ATS vs. good offensive teams - scoring 24 or more points/game. 8-3 OVER as a favorite of 3.5 to 9.5 points. 10-4 OVER in a road game where the total is between 42.5 and 49 points. 

Indianapolis Colts: 6-11 ATS when playing against a team with a winning record. 2-7 ATS vs. good offensive teams - scoring 24 or more points/game. 4-7 ATS in a home game where the total is greater than or equal to 45.5. 9-3 OVER as a home underdog of 7 points or less. 14-7 OVER after playing a game at home.

Jacksonville Jaguars:  None.

Indianapolis Colts:  None.

“He's doing it all. He’s doing everything that you want your guy to be doing, and he’s doing it at a high level right now.” - Liam Coen on Trevor Lawrence after his team’s win against the Broncos in their last game. 

“We've got to be better. Bottom line, we can't give up that many yards. They scored a lot of points, went up and down the field and we've got to get that cleaned up in a hurry. Our defense played great last week and then this week ... we've got to be better.” - Shane Steichen after his team’s loss against the 49ers in their last game. 

WR Thomas Jr., Brian

WR Meyers, Jakobi

WR Washington, Parker

TE Strange, Brenton

QB Lawrence, Trevor 

RB Etienne Jr., Travis

WR Pittman Jr., Michael

WR Pierce, Alec

WR Downs, Josh

TE Warren, Tyler

QB Rivers, Philip

RB Taylor, Jonathan

Passing: Trevor Lawrence (3,489)

Rushing: Travis Etienne Jr. (999)

Receiving: Parker Washington (645)

Touchdowns: Travis Etienne Jr. (13)

Passing: Daniel Jones (3,101)

Rushing: Jonathan Taylor (1,489)

Receiving: Alec Pierce (871)

Touchdowns: Jonathan Taylor (19)

Coaches:

Jacksonville Jaguars: Liam Coen (1st season)

Indianapolis Colts: Shane Steichen (3rd season)