by Rod Pearson
Friday, Nov 21, 2025
Game Time: 4:05 pm ET, Sunday, November 23, 2025
Venue: State Farm Stadium, Glendale, AZ
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Jaguars -3, Cardinals +3; Over/Under: 47.5 points
Bet365: Point Spread: Jaguars -3, Cardinals +3; Over/Under: 47.5 points
BetMGM: Point Spread: Jaguars -3, Cardinals +3; Over/Under: 47.5 points
Season Record
Jacksonville Jaguars: 6-4 (2nd place, AFC South)
Arizona Cardinals: 3-7 (4th place, NFC West)
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Jacksonville Jaguars: won their last game at home against the Los Angeles Chargers 35-6.
Arizona Cardinals: lost their last game at home against the San Francisco 49ers 41-22.
Jacksonville Jaguars vs Arizona Cardinals Preview and Analysis
The Jaguars are entering this game with a 6-4 record overall and they have a 1-1 record in their divisional games too. They are 4-1 in their home games, 2-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Los Angeles Chargers 35-6. Trevor Lawrence was the starting QB and he completed 14/22 passes for 153 passing yards, 1 touchdown, and 1 interception. Bhayshul Tuten led the team in rushing yards with 74 and 1 TD. Jakobi Meyers led the receivers with 64 receiving yards on 5 receptions. Foyesade Oluokun and Andrew Wingard each led the defense in that game with 3 solo tackles and 2 assisted tackles while Arik Armstead and Josh Hines-Allen each led the defense in sacks with 1. Antonio Johnson came away with the only interception for them in that one.
The Cardinals are entering this game with a 3-7 record overall and they have a 0-4 record in their divisional games too. They are 1-4 in their home games, 2-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the San Francisco 49ers 41-22. Jacoby Brissett was the starting QB and he completed 47/57 passes for 452 passing yards, 2 touchdowns, and 2 interceptions. Zonovan Knight led the team in rushing yards with 24 and 1 TD. Michael Wilson led the receivers with 185 receiving yards on 15 receptions. Cody Simon led the defense in that game with 4 solo tackles and 8 assisted tackles while Josh Sweat led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Jaguars vs Cardinals Prediction
The current betting odds have the Jaguars listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Jaguars have looked good in their games this season with their 6-4 record overall which has them right near the top of the AFC South. They haven't looked great lately as they fell into a slump, but they are off a nice bounce back win over the Chargers in their last one. Meanwhile, the Cardinals haven't looked good in their games this season with their 3-7 record overall which has them right at the bottom of the NFC West. They play in a really tough division with every other team above .500, and the NFC in general is very competitive this year so the Cardinals pretty much have no playoff hopes left. The offense didn't look terrible last week as Brissett set a new NFL record with 47 completions, but the defense was terrible and they still got blown out by the 49ers 41-22. The offense has also been really up and down this year and they haven't been able to run the ball with too many injuries to their RB's. The Jaguars were slumping, but that win over the Chargers is going to give them a ton of momentum here and they are still playing for something as they are right in the Wild Card race. This is the Jaguars game to lose with the way the Cardinals have looked lately. The best way to place a bet here is on the Jaguars to cover the spread in this game.
Jaguars Cardinals Prediction: Our NFL Pick for Sunday, November 23, 2025 (4:05 pm ET start time) is Jaguars 24 Cardinals 17.
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NFL Betting Trends
Jacksonville Jaguars: 8-24 ATS against NFC West division opponents. 19-33 ATS on the road when playing against a bad team (Win Pct. 25% to 40%). 13-22 ATS on the road after a win by 14 or more points. 8-3 OVER in a road game where the total is between 42.5 and 49 points. 6-3 OVER after allowing 14 points or less last game.
Arizona Cardinals: 21-13 ATS as an underdog. 9-3 ATS in non-conference games. 6-3 ATS after a game with a turnover margin of -2 or worse. 15-6 OVER in home games. 13-5 OVER in a home game where the total is between 42.5 and 49 points.
Key Injuries
Jacksonville Jaguars: J. Lewis (CB) Injured - Neck. A. Armstead (DL) Injured - Illness. D. Gardeck (LB) Injured - Chest. H. Long (TE) Injured - Hip. T. Etienne Jr. (RB) Injured - Shoulder. P. Mekari (OG) Injured - Knee. A. Wingard (S) Injured - Back. Y. Abdullah (LB) Injured - Finger. G. Newsome II (CB) Injured - Ankle. T. Walker (DL) Injured - Knee. B. Strange (TE) Injured - Hip. A. Harrison (OG) Injured - Knee. J. Jones (CB) Injured - Quadricep. B. Thomas Jr. (WR) Injured - Ankle. W. Milum (OG) Injured - Knee. B. Tuten (RB) Injured - Ankle.
Arizona Cardinals: K. Beachum (OG) Injured - Groin. J. Williams (OG) Injured - Shoulder. W. Hernandez (OG) Injured - Knee. B. Browning (LB) Injured - Concussion. E. Demercado (RB) Injured - Ankle. B. Knight (RB) Injured - Ankle. G. Williams (CB) Injured - Ankle. M. Harrison Jr. (WR) Injured - Illness. D. Robinson (DL) Injured - Groin. D. Taylor-Demerson (S) Injured - Ankle. T. Benson (RB) Injured - Knee. H. Conner (OG) Injured - Knee. W. Johnson (CB) Injured - Back.
Notable Quotes
“We were (ticked) off at the finish last week. We play better (ticked) off. We’ve talked about edge for a long time now. When we have an edge and we play as a team, and it’s about the team all the time, good things happen typically for us. I am proud of the response, for sure.” - Liam Coen after his team’s win against the LA Chargers in their last game.
“I am a defensive head coach and it's not acceptable. You can't win when you give up that many points and it really doesn't matter how you get there. You've got to stand up, play better, and keep points off the board.” - Jonathan Gannon after his team’s loss against the 49ers in their last game.
Starting Lineups
Jacksonville Jaguars
WR Patrick, Tim
WR Meyers, Jakobi
WR Washington, Parker
TE Mundt, Johnny
QB Lawrence, Trevor
RB Etienne Jr., Travis
Arizona Cardinals
WR Weaver, Xavier
WR Wilson, Michael
WR Dortch, Greg
TE McBride, Trey
QB Brissett, Jacoby
RB Knight, Bam
Statistical Leaders
Jacksonville Jaguars
Passing: Trevor Lawrence (2,151)
Rushing: Travis Etienne Jr. (729)
Receiving: Brian Thomas Jr. (420)
Touchdowns: Travis Etienne Jr. (6)
Arizona Cardinals
Passing: Jacoby Brissett (1,570)
Rushing: Emari Demercado (241)
Receiving: Trey McBride (718)
Touchdowns: Trey McBride (7)
Coaches:
Jacksonville Jaguars: Liam Coen (1st season)
Arizona Cardinals: Jonathan Gannon (3rd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
