by Rod Pearson
Thursday, Dec 11, 2025
Game Time: 4:25 pm ET, Sunday, December 14, 2025
Venue: Lumen Field, Seattle, WA
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Colts +13.5, Seahawks -13.5; Over/Under: 42.5 points
Bet365: Point Spread: Colts +14, Seahawks -14; Over/Under: 42.5 points
BetMGM: Point Spread: Colts +13.5, Seahawks -13.5; Over/Under: 42.5 points
Season Record
Indianapolis Colts: 8-5 (3rd place, AFC South)
Seattle Seahawks: 10-3 (2nd place, NFC West)
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Recent Form
Indianapolis Colts: lost their last game on the road against the Jacksonville Jaguars 36-19.
Seattle Seahawks: won their last game on the road against the Atlanta Falcons 37-9.
Indianapolis Colts vs Seattle Seahawks Preview and Analysis
The Colts are entering this game with an 8-5 record overall and they have a 2-2 record in their divisional games too. They are 5-1 in their home games, 2-4 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Jacksonville Jaguars 36-19. Daniel Jones was the starting QB and he completed 5/7 passes for 60 passing yards, 0 touchdowns, and 1 interception before leaving injured and getting replaced by Riley Leonard who completed 18/29 passes for 145 yards and 1 INT. Jonathan Taylor led the team in rushing yards with 74 and 1 TD. Alec Pierce led the receivers with 80 receiving yards on 5 receptions. Jaylon Jones led the defense in that game with 4 solo tackles and 0 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
The Seahawks are entering this game with a 10-3 record overall and they have a 3-1 record in their divisional games too. They are 5-1 in their home games, 5-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the Atlanta Falcons 37-9. Sam Darnold was the starting QB and he completed 20/30 passes for 249 passing yards, 3 touchdowns, and 1 interception. Zach Charbonnet led the team in rushing yards with 46. Jaxon Smith-Njigba led the receivers with 92 receiving yards on 7 receptions and 2 TDs. Ernest Jones IV led the defense in that game with 5 solo tackles and 6 assisted tackles while Nick Emmanwori led the defense in sacks with 1. Devon Witherspoon and Nick Emmanwori each came away with 1 interception for them in that one.
Colts vs Seahawks Prediction
The current betting odds have the Seahawks listed as a 13.5 point favorite in this game according to Draftkings Sportsbook. The Seahawks have looked great in their games this season with their 10-3 record overall which has them right near the top of the NFC West. They have looked great on their home field too with their 5-1 home record this year. Meanwhile, the Colts have looked good in their games this season with their 8-5 record overall, but that record has them right near the bottom of the AFC South. They haven't been a good road team this year either with their 2-4 road record. The Colts were one of the hottest teams in the NFL at the start of the season, but lately they haven't looked good and have been falling apart. Now they are dealing with some big injuries with Daniel Jones being out, and they don't really have a great option at backup, no matter who they go with in this one. They are off a 36-19 loss to the Jags in their last one and their playoff hopes are starting to slip away now with everything piling up. The Seahawks have been rolling in their games though, off a 37-9 win over the Falcons in their last one, and they have been blowing teams out like this all year. They have one of the best defenses in the NFL and they are still looking to finish as the number 1 seed in the NFC so they aren't going to take their foot off the gas in these final weeks, especially since they aren't even leading their own division. The Colts are going to struggle against this Seahawks defense with their current QB situation, look for the Seahawks to roll again. The best way to place a bet here is on the Seahawks to cover the spread in this game.
Colts Seahawks Prediction: Our NFL Pick for Sunday, December 14, 2025 (4:25 pm ET start time) is Seahawks 34 Colts 17.
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NFL Betting Trends
Indianapolis Colts: 3-9 ATS in non-conference games. 5-10 ATS when playing against a team with a winning record. 1-6 ATS vs. good offensive teams - scoring 24 or more points/game. 20-13 OVER in all games where the total is between 42.5 and 49 points. 5-0 OVER after a loss by 14 or more points.
Seattle Seahawks: 9-2 ATS after scoring 30 points or more last game. 10-4 ATS versus good rushing teams - averaging 4.5 rushing yards/carry or more. 5-2 ATS vs. poor passing defenses - allowing 235 or more passing yards/game. 10-4 OVER as a home favorite. 7-3 OVER after allowing 14 points or less last game.
Key Injuries
Indianapolis Colts: D. Buckner (DL) Injured - Neck. Z. Franklin (LB) Injured - Knee. B. Smith (OT) Injured - Concussion. T. Lewis (DL) Injured - Ankle. A. Pierce (WR) Injured - Rib. S. Gardner (CB) Injured - Calf. J. Downs (WR) Injured - Ankle. J. Jones (CB) Injured - Back. A. Gould (WR) Injured - Foot. R. Leonard (QB) Injured - Knee.
Seattle Seahawks: D. Lawrence (LB) Injured - NIR-Rest. E. Saubert (TE) Injured - Calf. J. Reed (DL) Injured - Wrist. L. Williams (DL) Injured - NIR-Rest. U. Nwosu (LB) Injured - NIR-Rest. C. White (WR) Injured - Abdomen. J. Love (S) Injured - Hamstring. E. Jones IV (LB) Injured - NIR-Rest. J. Smith-Njigba (WR) Injured - NIR-Rest. D. Young (WR) Injured - Quadricep. T. Okada (S) Injured - Oblique. J. Sundell (C) Injured - Knee. A. Barner (TE) Injured - Ankle. R. Mills (DL) Injured - Knee. E. Arroyo (TE) Injured - Knee.
Notable Quotes
“It's not looking good. Anytime you lose a guy that puts in so much work and so much effort, and is always there for his team, and showing up with a fibula injury, and goes out there and freaking plays, just so much respect for him. Just so much respect.” - Shane Steichen after his team’s loss against the Jaguars in their last game.
“I've not been able to play for a playoff team yet. This feels different. This feels like everyone has bought in.” - Rashid Shaheed after their win against the Falcons in their last game.
Starting Lineups
Indianapolis Colts
WR Pittman Jr., Michael
WR Pierce, Alec
WR Downs, Josh
TE Warren, Tyler
QB Leonard, Riley
RB Taylor, Jonathan
Seattle Seahawks
WR Smith-Njigba, Jaxon
WR Shaheed, Rashid
WR Kupp, Cooper
TE Barner, AJ
QB Darnold, Sam
RB Walker III, Kenneth
FB Ouzts, Robbie
Statistical Leaders
Indianapolis Colts
Passing: Daniel Jones (3,101)
Rushing: Jonathan Taylor (1,356)
Receiving: Alec Pierce (769)
Touchdowns: Jonathan Taylor (18)
Seattle Seahawks
Passing: Sam Darnold (3,162)
Rushing: Kenneth Walker III (762)
Receiving: Jaxon Smith-Njigba (1,428)
Touchdowns: Jaxon Smith-Njigba (9)
Coaches:
Indianapolis Colts: Shane Steichen (3rd season)
Seattle Seahawks: Mike Macdonald (2nd season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
