by Rod Pearson
Tuesday, Oct 28, 2025
Game Time: 1:00 pm ET, Sunday, November 2, 2025
Venue: Acrisure Stadium, Pittsburgh, PA
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Colts -3, Steelers +3; Over/Under: 50.5 points
Bet365: Point Spread: Colts -3, Steelers +3; Over/Under: 50.5 points
BetMGM: Point Spread: Colts -3, Steelers +3; Over/Under: 50.5 points
Season Record
Indianapolis Colts: 7-1 (1st place, AFC South)
Pittsburgh Steelers: 4-3 (1st place, AFC North)
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Indianapolis Colts: won their last game at home against the Tennessee Titans 38-14.
Pittsburgh Steelers: lost their last game at home against the Green Bay Packers 35-25.
Indianapolis Colts vs Pittsburgh Steelers Preview and Analysis
The Colts are entering this game with a 7-1 record overall and they have a 2-0 record in their divisional games too. They are 5-0 in their home games, 2-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Tennessee Titans 38-14. Daniel Jones was the starting QB and he completed 21/29 passes for 272 passing yards, 3 touchdowns, and 0 interceptions. Jonathan Taylor led the team in rushing yards with 153 and 2 TDs. Michael Pittman Jr. led the receivers with 95 receiving yards on 8 receptions and 1 TD. Kenny Moore II led the defense in that game with 4 solo tackles and 1 assisted tackle while DeForest Buckner, Neville Gallimore, and Adetomiwa Adebawore each led the defense in sacks with 1. Chris Lammons came away with the only interception for them in that one.
The Steelers are entering this game with a 4-3 record overall and they have a 1-1 record in their divisional games too. They are 1-2 in their home games, 2-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Green Bay Packers 35-25. Aaron Rodgers was the starting QB and he completed 24/36 passes for 219 passing yards, 2 touchdowns, and 0 interceptions. Jaylen Warren led the team in rushing yards with 62. Roman Wilson led the receivers with 74 receiving yards on 4 receptions and 1 TD. Payton Wilson led the defense in that game with 4 solo tackles and 4 assisted tackles while no one on the defense recorded a sack for them. No one on the defense came away with an interception for them in that one.
Colts vs Steelers Prediction
The current betting odds have the Colts listed as a 3 point favorite in this game according to Draftkings Sportsbook. The Colts have looked great in their games this season with their 7-1 record overall which has them right at the top of the AFC South with the best record in the entire NFL. They are off a 38-14 win over the Titans in their last one and they have been rolling over opponents all season. They have been the biggest surprise of the season with Daniel Jones reviving his career in Indianapolis, but they also have a good defense and one of the best running backs in the NFL too. Meanwhile, the Steelers have looked good in their games this season with their 4-3 record overall which has them right at the top of the AFC North. They had a great start to the season, but they haven't looked as good lately. They are off a 35-25 loss to the Packers in their last one and they have lost 2 games in a row now. Their defense is also supposed to be their strength, but they have looked terrible lately with over 30 points given up in 2 straight games. The offense has looked good with Rodgers, but they don't have a ton of weapons for him to work with and the run game hasn't been great either. The Colts are looking like a true Super Bowl contender this season and they are the better team in this game in every facet. The best way to place a bet here is on the Colts to cover the spread in this game.
Colts Steelers Prediction: Our NFL Pick for Sunday, November 2, 2025 (1:00 pm ET start time) is Colts 27 Steelers 20.
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NFL Betting Trends
Indianapolis Colts: 10-18 1H ATS in a road game where the total is greater than or equal to 49.5. 29-37 1H ATS off a home win against a division rival. 25-16 OVER in all games. 20-9 OVER against conference opponents. 8-4 OVER after scoring 30 points or more last game.
Pittsburgh Steelers: 17-10 ATS in games where the line is +3 to -3. 50-28 ATS when playing against a top-level team (Win Pct. > 75%). 33-20 ATS against teams with a turnover margin of +1 per game or better. 34-23 OVER at home vs. good teams - outscoring opponents by 6+ PPG on the season. 27-15 OVER at home after 2 or more consecutive losses.
Key Injuries
Indianapolis Colts: K. Moore II (CB) Injured - Achilles. G. Stewart (DL) Injured - Foot. S. Ebukam (DL) Injured - Knee. B. Smith (OT) Injured - Rest. T. Lewis (DL) Injured - Groin. N. Cross (S) Injured - Shoulder. J. Downs (WR) Injured - Hip. J. Jones (CB) Injured - Hamstring. M. Goncalves (OG) Injured - Personal. A. Gould (WR) Injured - Knee.
Pittsburgh Steelers: J. Smith (TE) Injured - NIR-Rest. I. Seumalo (OG) Injured - Pectoral. D. Elliott (S) Injured - Knee. D. Ekuale (DL) Injured - Knee. S. Miller (WR) Injured - Finger. M. Harrison (LB) Injured - Knee. B. Skowronek (WR) Injured - Neck. C. Trice Jr. (CB) Injured - Hamstring. P. Freiermuth (TE) Injured - Quadricep. Z. Frazier (C) Injured - Calf. W. Howard (QB) Injured - Hand.
Notable Quotes
“It’s hard to put into words, to be honest, because when you see the way he’s running, the way guys are blocking for him, it’s special. He’s running hard, running physical and even when things aren’t clean in there, he’s finding ways to get 3, 4 yards. When he hit that 80-yard touchdown run down the sideline and stayed in bounds, that’s as impressive as it gets.” - Shane Steichen after his team’s win against the Titans in their last game.
“We've just got to be better in all areas and it starts first with the positions that we put players in and so as coaches, as players, as all of us, we own it. We’ll be better. We have to be.” - Mike Tomlin after his team’s loss against the Packers in their last game.
Starting Lineups
Indianapolis Colts
WR Pittman Jr., Michael
WR Pierce, Alec
WR Downs, Josh
TE Warren, Tyler
QB Jones, Daniel
RB Taylor, Jonathan
Pittsburgh Steelers
WR Metcalf, DK
WR Austin III, Calvin
TE Smith, Jonnu
TE Washington, Darnell
QB Rodgers, Aaron
RB Warren, Jaylen
Statistical Leaders
Indianapolis Colts
Passing: Daniel Jones (2,062)
Rushing: Jonathan Taylor (850)
Receiving: Tyler Warren (492)
Touchdowns: Jonathan Taylor (14)
Pittsburgh Steelers
Passing: Aaron Rodgers (1,489)
Rushing: Jaylen Warren (373)
Receiving: DK Metcalf (461)
Touchdowns: DK Metcalf (5)
Coaches:
Indianapolis Colts: Shane Steichen (3rd season)
Pittsburgh Steelers: Mike Tomlin (19th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
