by Rod Pearson
Thursday, Oct 22, 2026
Game Time: 1:00 pm ET, Sunday, October 25, 2026
Venue: U.S. Bank Stadium, Minneapolis, MN
Where to Watch: CBS
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Colts +6.5, Vikings -6.5; Over/Under: 41.5 points
Bet365: Point Spread: Colts +6.5, Vikings -6.5; Over/Under: 41.5 points
BetMGM: Point Spread: Colts +6.5, Vikings -6.5; Over/Under: 41.5 points
Season Record
Indianapolis Colts: 2-4 (2nd place, AFC South)
Minnesota Vikings: 5-0 (1st place, NFC North)
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Recent Form
Indianapolis Colts: lost their last game at home against the Tennessee Titans 26-20.
Minnesota Vikings: won their last game on the road against the New Orleans Saints 23-13.
Indianapolis Colts vs Minnesota Vikings Preview and Analysis
The Colts are entering this game with a 2-4 record overall and they have a 1-1 record in their divisional games too. They are 1-2 in their home games, 0-2 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Tennessee Titans 26-20. Daniel Jones was the starting QB and he completed 22/42 passes for 269 passing yards, 1 touchdown, and 2 interceptions. Jonathan Taylor led the team in rushing yards with 94 and 1 TD. Keenan Allen led the receivers with 82 receiving yards on 8 receptions. Akeem Davis-Gaither led the defense in that game with 9 solo tackles while no one on the defense recorded a sack for them. Camryn Bynum came away with the only interception for them in that one.
The Vikings are entering this game with a 5-0 record overall and they have a 2-0 record in their divisional games too. They are 2-0 in their home games, 3-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against the New Orleans Saints 23-13. Kyler Murray was the starting QB and he completed 24/30 passes for 229 passing yards, 1 touchdown, and 0 interceptions. Aaron Jones led the team in rushing yards with 113 and 1 TD. Justin Jefferson led the receivers with 79 receiving yards on 6 receptions and 1 TD. Blake Cashman led the defense in that game with 9 solo tackles while Andrew Van Ginkel led the defense in sacks with 1. Byron Murphy came away with 2 interceptions for them in that one.
Colts vs Vikings Prediction
The current betting odds have the Vikings listed as a 6.5 point favorite in this game according to Draftkings Sportsbook. The Vikings have looked great in their games this season with their 5-0 record overall which has them right at the top of the NFC North. They have looked good on their home field too with their 2-0 home record this season. Meanwhile, the Colts haven't looked good in their games this season with their 2-4 record overall which has them right in the middle of the AFC South. They haven't been a good road team either with their 0-2 road record this year. The Colts have been really up and down to start the season with some games that they looked great in and some games that they looked terrible in. They haven't looked great since coming back from England though and now they are coming off a 26-20 loss at home to the Titans who were winless at the time. They have a lot of talent on offense, but they are too streaky and it hasn't helped that Daniel Jones has taken a step back from the way he played last season in the 1st half. The Vikings have been rolling in their games and they are in a great situation here, coming out of their bye week. They are one of the few undefeated teams left in the NFL this season and they have been winning their games with one of the worst offenses in the NFL. The defense has really carried them in their 5 games with one of the best defenses in the league, but they are coming off a 23-13 road win over the Saints in which their offense looked a lot better in and now they have had 2 weeks to fix things with the bye week. Look for the Vikings to come out of their bye week strong and roll over a Colts team that has been reeling the last 2 weeks. The best way to place a bet here is on the Vikings to cover the spread in this game.
Colts Vikings Prediction: Our NFL Pick for Sunday, October 25, 2026 (1:00 pm ET start time) is Vikings 27 Colts 17.
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NFL Betting Trends
Indianapolis Colts: 3-7 ATS in non-conference games. 5-10 ATS when playing against a team with a winning record. 2-5 1H ATS in a road game where the total is between 35.5 and 42 points. 8-3 UNDER after playing a division game. 6-3 UNDER after a loss by 6 or less points.
Minnesota Vikings: 24-15 ATS in all games. 9-2 ATS after allowing 14 points or less last game. 10-5 ATS after playing their last game on the road. 9-3 UNDER in all games where the total is between 35.5 and 42 points. 12-3 UNDER after playing their last game on the road.
Key Injuries
Indianapolis Colts: M. Goncalves (OG) Injured - Ankle. A. Gould (WR) Injured - Concussion. D. Ogletree (TE) Injured - Ankle. R. Sanchez (P) Injured - Foot. J. Taylor (RB) Injured - NIR - Rest. J. Tillery (DL) Injured - NIR - Personal. J. Travis (OT) Injured - Foot. J. Walley (CB) Injured - Knee. C. Ward (CB) Injured - NIR - Rest. A. Ajiake (LB) Injured - Concussion. K. Allen (WR) Injured - NIR - Rest. B. Boettcher (LB) Injured - Groin. J. Carlies (LB) Injured - Ribs. A. Dulin (WR) Injured - Hamstring. S. Gardner (CB) Injured - Calf. T. Warren (TE) Injured - Groin.
Minnesota Vikings: B. O'Neill (OT) Injured - Knee. J. Pierre (CB) Injured - Foot. T. Hockenson (TE) Injured - Concussion. J. Jefferson (WR) Injured - Ankle. C. Darrisaw (OT) Injured - Concussion. J. Mason (RB) Injured - Thumb. J. Addison (WR) Injured - Hamstring. C. Demmings (CB) Injured - Hamstring.
Notable Quotes
“We've got a lot to fix, and we've got to fix it in a hurry. Turnovers continue to be an issue, we've got to handle that better. We can't give up blocked punts, we can't give up a kick return.” - Shane Steichen after his team’s loss against the Titans in their last game.
“A touchdown to celebrate and to get a victory here, I couldn’t ask for more.” - Justin Jefferson after their win against the Saints in their last game.
Starting Lineups
Indianapolis Colts
WR Treadwell, Laquon
WR Allen, Keenan
WR Downs, Josh
TE Alie-Cox, Mo
QB Jones, Daniel
RB Taylor, Jonathan
Minnesota Vikings
WR Jefferson, Justin
WR Addison, Jordan
WR Jennings, Jauan
TE Hockenson, T.J.
QB Murray, Kyler
RB Jones Sr., Aaron
FB Bredeson, Max
Statistical Leaders
Indianapolis Colts
Passing: Daniel Jones (1,290)
Rushing: Jonathan Taylor (492)
Receiving: Josh Downs (289)
Touchdowns: Jonathan Taylor (7)
Minnesota Vikings
Passing: Kyler Murray (662)
Rushing: Aaron Jones Sr. (410)
Receiving: Justin Jefferson (258)
Touchdowns: Justin Jefferson (3)
Coaches:
Indianapolis Colts: Shane Steichen (4th season)
Minnesota Vikings: Kevin O'Connell (5th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
