Indianapolis Colts vs Jacksonville Jaguars Prediction, Preview and Odds - 12/07/2025

Game Time: 1:00 pm ET, Sunday, December 7, 2025

Venue:  EverBank Stadium, Jacksonville, FL

Where to Watch:  CBS

DraftKings:  Point Spread:  Colts -1.5, Jaguars +1.5; Over/Under:  48.5 points

Bet365:  Point Spread:  Colts -1.5, Jaguars +1.5; Over/Under:  47.5 points

BetMGM:  Point Spread:  Colts -1.5, Jaguars +1.5; Over/Under:  47.5 points

Indianapolis Colts:  8-4 (2nd place, AFC South)

Jacksonville Jaguars:  8-4 (1st place, AFC South)

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Indianapolis Colts:  lost their last game at home against the Houston Texans 20-16.

Jacksonville Jaguars:  won their last game on the road against the Tennessee Titans 25-3.

The Colts are entering this game with an 8-4 record overall and they have a 2-1 record in their divisional games too. They are 5-1 in their home games, 2-3 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against the Houston Texans 20-16. Daniel Jones was the starting QB and he completed 14/27 passes for 201 passing yards, 2 touchdowns, and 0 interceptions. Jonathan Taylor led the team in rushing yards with 85. Alec Pierce led the receivers with 78 receiving yards on 4 receptions and 1 TD. Zaire Franklin led the defense in that game with 5 solo tackles and 8 assisted tackles while Chris Wormley and Adetomiwa Adebawore each led the defense in sacks with 1. Camryn Bynum came away with the only interception for them in that one.

 

 

 

The Jaguars are entering this game with an 8-4 record overall and they have a 2-1 record in their divisional games too. They are 4-1 in their home games, 4-2 in their road games, and they are also 0-1 in their neutral site games this season, but they will be at home for this game. They won their last game against the Tennessee Titans 25-3. Trevor Lawrence was the starting QB and he completed 16/27 passes for 229 passing yards, 2 touchdowns, and 0 interceptions. Travis Etienne Jr. led the team in rushing yards with 28. Jakobi Meyers led the receivers with 90 receiving yards on 6 receptions and 1 TD. Montaric Brown led the defense in that game with 6 solo tackles and 1 assisted tackle while Josh Hines-Allen led the defense in sacks with 2. No one on the defense came away with an interception for them in that one.

The current betting odds have the Colts listed as a 1.5 point favorite in this game according to Draftkings Sportsbook. The Colts have looked really good in their games this season with their 8-4 record overall which has them right near the top of the AFC South. They haven't been a great road team though with their 2-3 road record this season. Meanwhile, the Jaguars have looked really good in their games this season with their 8-4 record overall which has them right at the top of the AFC South. They have looked great on their home field too with their 4-1 home record. They are off a 25-3 win over the Titans in their last one and that win has put them in 1st place of the division with the Colts losing last week. The Colts are off a 20-16 loss at home to the Texans in their last one and they have given the Texans life in this division now, but the Colts have still looked like the best team in the AFC South all season and they will be looking to bounce back after losing such a pivotal game. The Jags now lead the division so the Colts are going to bring their best effort for this game, and they do have the better offense that has been a lot more consistent all year. The Colts have one of the best RB's in the NFL to lean on and Daniel Jones hasn't looked bad in this offense either. The Jaguars have been really up and down this season with inconsistencies on both sides of the ball and they have had to play in a lot more dog fights than the Colts who have had more control in their games. The Colts need to show up in this game to keep hold of the division and they will be desperate to bounce back after a bad stretch of games. The best way to place a bet here is on the Colts to cover the spread in this game. 

Colts Jaguars Prediction:  Our NFL Pick for Sunday, December 7, 2025 (1:00 pm ET start time) is Colts 24 Jaguars 20.

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Indianapolis Colts: 5-9 ATS when playing against a team with a winning record. 1-5 ATS vs. good offensive teams - scoring 24 or more points/game. 3-7 ATS on the road after playing a division game. 6-1 UNDER after a loss by 6 or less points. 5-1 UNDER vs. good offensive teams - scoring 24 or more points/game.

Jacksonville Jaguars: 18-10 ATS in all games where the total is between 42.5 and 49 points. 10-4 ATS versus division opponents. 10-4 ATS when playing against a good team (Win Pct. 60% to 75%). 8-3 UNDER as a home underdog of 7 points or less. 12-5 UNDER after playing their last game on the road.

Indianapolis Colts:  K. Moore II (CB) Injured - Illness. T. Lewis (DL) Injured - Ankle. D. Jones (QB) Injured - Fibula. S. Gardner (CB) Injured - Calf. J. Downs (WR) Injured - Hip. J. Carlies (LB) Injured - Ankle.

Jacksonville Jaguars:  J. Lewis (CB) Injured - Neck. E. Murray (S) Injured - Neck. A. Armstead (DL) Injured - Hand. F. Oluokun (LB) Injured - Hamstring. L. Cooke (P) Injured - Shoulder. R. Matiscik (LS) Injured - Back. C. Edoga (OG) Injured - Calf. W. Little (OG) Injured - Concussion. D. Lloyd (LB) Injured - Chest. P. Mekari (OG) Injured - Concussion. A. Wingard (S) Injured - Concussion. T. Walker (DL) Injured - Knee. P. Washington (WR) Injured - Hip. D. Striggow (DL) Injured - Knee.

“Sometimes you win the tight games, but when you lose the tight games it's frustrating because you're like ‘Shoot, we could have had that.’ You look back, it's three or four plays when you lose the tight ones so we've got to find a way to get those three or four plays when it is a tight game.” - Shane Steichen after his team’s loss against the Texans in their last game. 

“We’re giving ourselves an opportunity to play meaningful games in November and December, and ultimately that’s all you can ask for in this league. The rest of the way you've got competitive, meaningful football games.” - Liam Coen after his team’s win against the Titans in their last game. 

WR Pittman Jr., Michael

WR Pierce, Alec

WR Downs, Josh

TE Warren, Tyler

QB Jones, Daniel

RB Taylor, Jonathan

WR Thomas Jr., Brian

WR Meyers, Jakobi

WR Washington, Parker

TE Strange, Brenton

QB Lawrence, Trevor 

RB Etienne Jr., Travis

Passing: Daniel Jones (3,041)

Rushing: Jonathan Taylor (1,282)

Receiving: Alec Pierce (689)

Touchdowns: Jonathan Taylor (17)

Passing: Trevor Lawrence (2,636)

Rushing: Travis Etienne Jr. (843)

Receiving: Brian Thomas Jr. (448)

Touchdowns: Travis Etienne Jr. (7)

Coaches:

Indianapolis Colts: Shane Steichen (3rd season)

Jacksonville Jaguars: Liam Coen (1st season)