by Rod Pearson
Monday, Nov 24, 2025
Game Time: 7:30 pm ET, Friday, November 28, 2025
Venue: Ross–Ade Stadium, West Lafayette, IN
Where to Watch: NBC, Peacock
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Indiana -28.5, Purdue +28.5; Over/Under: 54.5 points
Bet365: Point Spread: Indiana -28.5, Purdue +28.5; Over/Under: 54.5 points
BetMGM: Point Spread: Indiana -28.5, Purdue +28.5; Over/Under: 54.5 points
Season Record
Indiana Hoosiers: 11-0 (8-0) (1st place, Big Ten)
Purdue Boilermakers: 2-9 (0-8) (18th place, Big Ten)
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Recent Form
Indiana Hoosiers: won their last game at home against the Wisconsin Badgers 31-7.
Purdue Boilermakers: lost their last game on the road against the Washington Huskies 49-13.
Indiana Hoosiers vs Purdue Boilermakers Preview and Analysis
Indiana is entering this game with an 11-0 record overall and they have an 8-0 record in their conference games too. They are 7-0 in their home games, 4-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Wisconsin 31-7. Fernando Mendoza was the starting QB and he completed 22/24 passes for 299 passing yards, 4 touchdowns, and 0 interceptions. Roman Hemby led the team in rushing yards with 58. Charlie Becker led the receivers with 108 receiving yards on 5 receptions and 1 TD. Rolijah Hardy led the defense in that game with 4 solo tackles and 2 assisted tackles while Rolijah Hardy and Dominique Ratcliff each led the defense in sacks with 1. Devan Boykin came away with the only interception for them in that one.
Purdue is entering this game with a 2-9 record overall and they have a 0-8 record in their conference games too. They are 2-4 in their home games, 0-5 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Washington 49-13. Malachi Singleton was the starting QB and he completed 16/28 passes for 150 passing yards, 1 touchdown, and 0 interceptions. EJ Horton Jr. led the team in rushing yards with 31. Nitro Tuggle led the receivers with 57 receiving yards on 3 receptions. Mani Powell led the defense in that game with 7 solo tackles and 2 assisted tackles while Mani Powell led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.
Indiana vs Purdue Prediction
The current betting odds have Indiana listed as a 28.5 point favorite in this game according to Draftkings Sportsbook. Indiana has looked great in their games this season with their 11-0 record overall and their 8-0 conference record which has them right at the top of the Big Ten. They are currently ranked inside the top 2 teams in the nation and they are coming out of their bye week for this final game of the regular season. Meanwhile, Purdue has looked terrible in their games this season with their 2-9 record overall and their 0-8 conference record which has them right at the bottom of the Big Ten. They have been one of the worst teams in the conference all year, being 1 of 2 teams in the Big Ten who do not have a conference win, and they aren't going to pick one up here against one of the best teams in the nation. Purdue really has nothing left to play for in this game other than a possible upset win over the 2nd ranked team in the nation, but Indiana is off a 31-7 win over Wisconsin in their last one and has been doing that to the bad teams in the conference all season. Purdue is off a 49-13 loss to Washington in their last one and their offense hasn't been putting up many points lately either. They are going to have a ton of trouble moving the ball on this Indiana defense while Indiana goes up and down the field with ease. The best way to place a bet here is on Indiana to cover the spread in this game.
Indiana Purdue Prediction: Our NCAAF Pick for Friday, November 28, 2025 (7:30 pm ET start time) is Indiana 48 Purdue 10.
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NCAAF Betting Trends
Indiana Hoosiers: 22-14 ATS in all lined games. 9-2 ATS off a home win by 17 points or more. 12-4 ATS after allowing 14 points or less last game. 23-13 OVER in all lined games. 16-8 OVER as a favorite. 16-4 OVER after playing a game at home.
Purdue Boilermakers: 11-23 ATS in all lined games. 4-8 ATS as a home underdog. 4-8 ATS after scoring 14 points or less last game. 2-10 ATS vs. good offensive teams - scoring 31 or more points/game. 8-4 OVER after scoring 14 points or less last game. 10-4 OVER after a loss by 17 or more points.
Key Injuries
Indiana Hoosiers: D. Evans (OG) Questionable - Undisclosed. B. Franke (K) Questionable - Undisclosed. E. Sarratt (WR) Questionable - Hamstring. K. Wyatt (DL) Out - Undisclosed. B. Bonds (CB) Out - Undisclosed. L. Beebe Jr. (RB) Out - Leg. T. Morris (WR) Out - Knee.
Purdue Boilermakers: G. Burhenn (TE) Questionable - Undisclosed. D. Morrissette (WR) Questionable - Undisclosed. J. Hall (WR) Out - Leg. D. Mockobee (RB) Out - Undisclosed. C. Magwood (WR) Out - Undisclosed.
Notable Quotes
“I did what’s always worked for me in those situations before. Instead of going in and kind of snorting at halftime, I just told everyone take a deep breath, relax and have fun. I thought we played a good second half, a lot of good individual performances." - Curt Cignetti after his team’s win against Wisconsin in their last game.
“I know what they’ve done, win-loss record, but I don’t know any details other than that. I know Cignetti has done a heck of a job.” - Barry Odom on his team’s upcoming game against Indiana this week.
Starting Lineups
Indiana Hoosiers
WR Sarratt, Elijah
WR Williams Jr., E.J.
WR Cooper Jr., Omar
TE Nowakowski, Riley
QB Mendoza, Fernando
RB Hemby, Roman
Purdue Boilermakers
WR Tuggle, Nitro
WR Horton Jr., EJ
WR Jackson III, Michael
TE Moore, Christian
QB Browne, Ryan
RB Harris, Antonio
Statistical Leaders
Indiana Hoosiers
Passing: Fernando Mendoza (2,641)
Rushing: Roman Hemby (714)
Receiving: Omar Cooper Jr. (740)
Touchdowns: Omar Cooper Jr. (11)
Purdue Boilermakers
Passing: Ryan Browne (1,915)
Rushing: Devin Mockobee (521)
Receiving: Michael Jackson III (504)
Touchdowns: Devin Mockobee (5)
Coaches:
Indiana Hoosiers: Curt Cignetti (2nd season)
Purdue Boilermakers: Barry Odom (1st season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
