by Rod Pearson
Wednesday, Dec 03, 2025
Game Time: 8:00 pm ET, Saturday, December 6, 2025
Venue: Lucas Oil Stadium, Indianapolis, IN
Where to Watch: FOX
Opening Odds at USA Sportsbooks
DraftKings: Point Spread: Indiana +4.5, Ohio State -4.5; Over/Under: 47.5 points
Bet365: Point Spread: Indiana +4.5, Ohio State -4.5; Over/Under: 48 points
BetMGM: Point Spread: Indiana +4.5, Ohio State -4.5; Over/Under: 48.5 points
Season Record
Indiana Hoosiers: 12-0 (9-0) (1st place, Big Ten)
Ohio State Buckeyes: 12-0 (9-0) (2nd place, Big Ten)
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Recent Form
Indiana Hoosiers: won their last game on the road against the Purdue Boilermakers 56-3.
Ohio State Buckeyes: won their last game on the road against the Michigan Wolverines 27-9.
Indiana Hoosiers vs Ohio State Buckeyes Preview and Analysis
Indiana is entering this game with a 12-0 record overall and they have a 9-0 record in their conference games too. They are 7-0 in their home games, 5-0 in their road games, and they are also 0-0 in their neutral site games this season, and they will be at a neutral site for this game. They won their last game against Purdue 56-3. Fernando Mendoza was the starting QB and he completed 8/15 passes for 117 passing yards, 2 touchdowns, and 0 interceptions. Roman Hemby led the team in rushing yards with 152 and 1 TD. Davion Chandler led the receivers with 65 receiving yards on 1 reception and 1 TD. Aiden Fisher led the defense in that game with 5 solo tackles and 2 assisted tackles while Stephen Daley led the defense in sacks with 1. Amare Ferrell came away with the only interception for them in that one.
Ohio State is entering this game with a 12-0 record overall and they have a 9-0 record in their conference games too. They are 7-0 in their home games, 5-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at a neutral site for this game. They won their last game against Michigan 27-9. Julian Sayin was the starting QB and he completed 19/26 passes for 233 passing yards, 3 touchdowns, and 1 interception. Bo Jackson led the team in rushing yards with 117. Carnell Tate led the receivers with 82 receiving yards on 5 receptions and 1 TD. Sonny Styles led the defense in that game with 3 solo tackles and 3 assisted tackles while Kenyatta Jackson Jr. led the defense in sacks with 1. Davison Igbinosun came away with the only interception for them in that one.
Indiana vs Ohio State Prediction
The current betting odds have Ohio State listed as a 4.5 point favorite in this game according to Draftkings Sportsbook. Ohio State has looked great in their games this season with their 12-0 record overall and their 9-0 conference record which has them right at the top of the Big Ten. Meanwhile, Indiana has looked great in their games this season with their 12-0 record overall and their 9-0 conference record which has them right at the top of the Big Ten. Both of these teams have been perfect all season and earned the right to play in this game with no tiebreakers involved. They are also the top 2 teams in the nation with Ohio State being ranked number 1 and Indiana being ranked number 2. Indiana is off a 56-3 win over Purdue in their last one and they have been blowing teams out like that all season, but Purdue is also one of the worst teams in the Big Ten and Indiana hasn't looked as good against more talented teams. They have a really nice win over Oregon on the road, but they struggled in both of their games against Iowa and Penn State. Ohio State has also been blowing out a lot of teams this year and they haven't been doing it with offense, but they have one of the best defenses in the nation and teams haven't been able to move the ball against them. Their offense hasn't had to do much all year since their defense has been so good, and they have so much talent on both sides of the ball that no team has even been close to them in any games this year. Indiana still doesn't have the talent that Ohio State has this year and this game is going to look a lot like when these two met last season. The best way to place a bet here is on Ohio State to cover the spread in this game.
Indiana Ohio State Prediction: Our NCAAF Pick for Saturday, December 6, 2025 (8:00 pm ET start time) is Ohio State 31 Indiana 14.
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NCAAF Betting Trends
Indiana Hoosiers: 34-53 ATS as an underdog of 3.5 to 10 points. 2-5 ATS off a road blowout win by 28 points or more. 43-61 ATS when playing against a top-level team (Win Pct. > 75%). 4-1 UNDER on the road versus good offensive teams - averaging 425 yards/game or more.
Ohio State Buckeyes: 27-12 ATS in all lined games. 6-1 ATS as a favorite of 3.5 to 10 points. 20-7 ATS after allowing 14 points or less last game. 16-3 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 26-14 UNDER as a favorite.
Key Injuries
Indiana Hoosiers: D. Evans (OG) Questionable - Undisclosed. E. Williams Jr. (WR) Questionable - Undisclosed. B. Franke (K) Questionable - Undisclosed. K. Wyatt (DL) Out - Undisclosed. B. Bonds (CB) Out - Undisclosed. L. Beebe Jr. (RB) Out - Leg. T. Morris (WR) Out - Knee.
Ohio State Buckeyes: M. Roy (DL) Questionable - Undisclosed. A. Tounkara (DL) Questionable - Undisclosed. L. George (DL) Questionable - Undisclosed. M. Maggs (QB) Questionable - Undisclosed. Q. Porter (WR) Questionable - Undisclosed. M. Hartford (S) Questionable - Undisclosed. D. Jones (WR) Questionable - Undisclosed.
Notable Quotes
“I think we put on one or two. It was a good day.” - Curt Cignetti after his team’s win against Purdue in their last game.
“Nobody wants to win this game more than me. To win this game, it’s just a great moment. It’s one of those moments that you want to just grab on for a while and just enjoy it.” - Ryan Day after his team’s win against Michigan in their last game.
Starting Lineups
Indiana Hoosiers
WR Sarratt, Elijah
WR Williams Jr., E.J.
WR Cooper Jr., Omar
TE Nowakowski, Riley
QB Mendoza, Fernando
RB Hemby, Roman
Ohio State Buckeyes
WR Tate, Carnell
WR Smith, Jeremiah
WR Inniss, Brandon
TE Klare, Max
QB Sayin, Julian
RB Jackson, Bo
Statistical Leaders
Indiana Hoosiers
Passing: Fernando Mendoza (2,758)
Rushing: Roman Hemby (866)
Receiving: Omar Cooper Jr. (804)
Touchdowns: Omar Cooper Jr. (12)
Ohio State Buckeyes
Passing: Julian Sayin (3,065)
Rushing: Bo Jackson (952)
Receiving: Jeremiah Smith (942)
Touchdowns: Jeremiah Smith (12)
Coaches:
Indiana Hoosiers: Curt Cignetti (2nd season)
Ohio State Buckeyes: Ryan Day (8th season)
Rod Pearson
About the Author:
Rod Pearson has been a rabid sports fan his entire life. He grew up in Ontario, and was skilled in both hockey and baseball, and pitched in an elite baseball league for many years. In 2022, Rod decided to hang up his glove, so that he could write about the sports he loves -- but from a gambling perspective. Join Rod every day as he breaks down the games to find the best betting value.
