Houston Astros vs New York Yankees Prediction, Preview and Odds - 08/27/2026

Game Time: 7:05 pm ET, Thursday, August 27, 2026

Venue:  Yankee Stadium, Bronx, NY

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Astros +125, Yankees -151; Over/Under:  8 runs

Bet365:  Moneyline odds:  Astros +125, Yankees -150; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Astros +125, Yankees -150; Over/Under:  8 runs

Houston Astros:  66-66 (1st place, AL West)

New York Yankees:  74-57 (2nd place, AL East)

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Houston Astros:  4-6 last 10

New York Yankees:  6-4 last 10

The Astros are entering this series off a loss and lost their 3-game series against the Athletics 2-1 in their last series. They enter this game with a 66-66 record overall and have a road record of 33-31. This is the series finale of a 3-game series with the Yankees on Thursday with the 2nd game still to be played on Wednesday. The Astros won the series opener on Tuesday. Their offense ranks 9th in the MLB with a .730 OPS. Peter Lambert is their starting pitcher on Wednesday while Hayden Wesneski is making his start in this game on Thursday. He is 3-1 with a 4.23 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 3 BB with 4 SO on 1 hit through 5 IP against the Athletics.

The Yankees are entering this series off a win and won their 3-game series against the Toronto Blue Jays 2-1 in their last series. They enter this game with a 74-57 record overall and have a home record of 33-29. This is the 3rd game of a 3-game series with the Astros on Thursday with the 2nd game of this series still to be played on Wednesday. The Yankees lost the 1st game of this series on Tuesday. Their offense ranks 16th in the MLB with a .718 OPS. Elmer Rodríguez is their starting pitcher on Wednesday while Gerrit Cole is making his start in this game on Thursday. He is 7-6 with a 3.11 ERA this season. His team won 4 of their last 5 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 walk with 8 strikeouts on 4 hits through 6 innings pitched against the Baltimore Orioles.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked really good in their games this season with their 74-57 record overall which has them right near the top of the AL East. They have looked good in their own ballpark too with their 33-29 home record this season. Meanwhile, the Astros haven't looked great in their games this season with their 66-66 record overall, but that record has them right at the top of the AL West. They have been a good road team too with their 33-31 road record this year. The Astros have been one of the hottest teams in the league over the last 2 months as they looked dead in the water and managed to go on a run, now leading their division, but they are still only .500 on the season and haven't looked that great lately, going 4-6 in their last 10 games. The Yankees have looked good lately, going 6-4 in their last 10 games as they try to chase down the Rays in their division, and they are going to have the better pitching matchup here. The Yankees are going with Cole in this one and he has looked good this season. He is 7-6 with a 3.11 ERA and he has been a stud for them all year. He is coming off another great start giving up 1 earned run which has been a common theme for him and the team has been having a lot of success with him lately, winning 4 of their last 5 games with him starting. The Astros are going with Wesneski in this one and he hasn't looked great this year. He is 3-1 with a 4.23 ERA and he has been giving up quite a few runs this season. He is coming off a good start in which he gave up no runs and the team has been having success with him lately, winning 4 of their last 5 games with him starting, but that hasn't been a common theme for him. The Yankees also have a really good offense along with the better bullpen, so look for the Yankees to take advantage of this pitching matchup. The best way to place a bet here is on the Yankees to win this game. 

Astros Yankees Prediction:  Our MLB Pick for Thursday, August 27, 2026 (7:05 pm ET start time) is Yankees 6 Astros 3.

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Houston Astros: 117-108 (+7.8 units) on the moneyline in road games. 62-54 (+9.8 units) on the moneyline vs. teams outscoring opp by 0.5 or more runs/game on the season. 110-100 (+9 units) on the moneyline when playing against a team with a winning record. 23-15 UNDER as a road underdog of +125 to +175.

New York Yankees: 272-203 (-18 units) on the moneyline in all games. 134-102 (-29.8 units) on the moneyline in home games. 229-161 (-24.9 units) on the moneyline as a favorite of -110 or higher. 42-26 UNDER when the money line is -100 to -150.

Houston Astros:  B. Matthews (CF) Sixty Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. B. Walter (RP) Sixty Day IL - Elbow.

New York Yankees:  R. Weathers (SP) Fifteen Day IL - Forearm. R. McMahon (3B) Ten Day IL - Thumb. M. Fried (SP) Fifteen Day IL - Elbow. K. Castro (RP) Fifteen Day IL - Elbow. A. Judge (RF) Sixty Day IL - Rib. G. Stanton (DH) Sixty Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

“This is the way we need to come here and play today. Any other way wasn’t going to be acceptable. We needed to come here today and play like a team that is hunting to win a division, and we did.” - Joe Espada after his team’s win against the Yankees in their game on Tuesday.

“They beat our guys tonight, so you’ve got to give them some credit there. They got us slug for slug. We kept answering for the most part, but they just did a little bit more offensively tonight.” - Aaron Boone after his team’s loss against the Astros in their game on Tuesday.

Jeremy Peña (R) SS

Yordan Alvarez (L) DH

Isaac Paredes (R) 3B

Jose Altuve (R) 2B

Daulton Varsho (L) CF

Christian Walker (R) 1B

LaMonte Wade Jr. (L) RF

Yainer Diaz (R) C

Taylor Trammell (L) LF

Trent Grisham (L) CF

Ben Rice (L) DH

Luis García Jr. (L) 1B

Cody Bellinger (L) LF

George Lombard Jr. (R) SS

Spencer Jones (L) RF

Jazz Chisholm Jr. (L) 2B

Austin Wells (L) C

José Caballero (R) 3B

Batting Average:  Yordan Alvarez (.323)

Hits:  Yordan Alvarez (151)

Home Runs:  Yordan Alvarez (36)

RBI:  Yordan Alvarez (91)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (19)

ERA:  Josh Hader (0.81)

Batting Average:  George Lombard (.286)

Hits:  Ben Rice (117)

Home Runs:  Ben Rice (34)

RBI:  Ben Rice (82)

Stolen Bases:  Jazz Chisholm (35)

Wins:  Cam Schlittler (11)

Saves:  David Bednar (30)

ERA:  Yerry De los Santos (1.02)

Managers:

Houston Astros: Joe Espada (3rd season)

New York Yankees: Aaron Boone (9th season)